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  4. Recombinant Danio rerio Neurogenic differentiation factor 1 (neurod1)

Recombinant Danio rerio Neurogenic differentiation factor 1 (neurod1)

  • 中文名稱：
    斑馬魚neurod1重組蛋白
  • 貨號(hào)：
    CSB-YP015725DIL
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    斑馬魚neurod1重組蛋白
  • 貨號(hào)：
    CSB-EP015725DIL
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    斑馬魚neurod1重組蛋白
  • 貨號(hào)：
    CSB-EP015725DIL-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    斑馬魚neurod1重組蛋白
  • 貨號(hào)：
    CSB-BP015725DIL
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    斑馬魚neurod1重組蛋白
  • 貨號(hào)：
    CSB-MP015725DIL
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    neurod1; neurod; nrdNeurogenic differentiation factor 1; NeuroD; NeuroD1
  • 種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-350
  • 氨基酸序列
    MTKSYSEESM MLESQSSSNW TDKCHSSSQD ERDVDKTSEP MLNDMEDDDD AGLNRLEDED DEEEEEEEED GDDTKPKRRG PKKKKMTKAR MQRFKMRRMK ANARERNRMH GLNDALESLR KVVPCYSKTQ KLSKIETLRL AKNYIWALSE ILRSGKSPDL MSFVQALCKG LSQPTTNLVA GCLQLNPRTF LPEQSQEMPP HMQTASASFS ALPYSYQTPG LPSPPYGTMD SSHIFHVKPH AYGSALEPFF DTTLTDCTSP SFDGPLSPPL SVNGNFSFKH EPSSEFEKNY AFTMHYQAAG LAGAQGHAAS LYAGSTQRCD IPMENIMSYD GHSHHERVMN AQLNAIFHDS
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.
  • 基因功能參考文獻(xiàn)：
    1. during embryonic development, NeuroD governs photoreceptor genesis via non-cell-autonomous mechanisms and that, during photoreceptor development and regeneration, Notch signaling is a mechanistic link between NeuroD and cell cycle exit. PMID: 26580854
    2. differential levels of Neurod are required to generate endocrine pancreas subtypes from precursors during both embryonic and larval stages PMID: 25797153
    3. Transcription factor neuroD, involved in retinogenesis, is co-opted by the circadian clock following photoreceptor differentiation. PMID: 24924194
    4. Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet. PMID: 19759004
    5. The control of endocrine cell fate is instead fulfilled by two basic helix-loop-helix factors, Ascl1b and Neurod1 and NEUROG3 is not the unique pancreatic endocrine cell fate determinant in vertebrates. PMID: 23835295
    6. the quantity, rather than quality (i.e., the ON/OFF states), of neurod expression directly or indirectly determines the two subtypes of posterior lateral line neurons PMID: 23303935
    7. BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain. PMID: 12204253
    8. in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1 PMID: 16678150
    9. Coexpressed with cone-rod-homeobox transcription factor (Crx) in putative cone progenitors and nascent cone photoreceptors. In zebrafish retina, similar genetic cascades may regulate photoreceptor genesis and maturation. PMID: 17206615
    10. NeuroD plays a fundamental role in photoreceptor genesis by regulating mechanisms that promote rod and cone progenitors to withdraw from the cell cycle. PMID: 19121642

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    In the embryo, expressed broadly in a subset of primary neurons in the brain and spinal cord. At 28 hours post-fertilization (hpf), regions of expression include telencephalon, olfactory placode, epiphysis, cranial ganglia, acoustic ganglia, Rohon-Beard m
  • 數(shù)據(jù)庫鏈接：