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  4. Recombinant Drosophila melanogaster ATP-dependent RNA helicase p62 (Rm62), partial

Recombinant Drosophila melanogaster ATP-dependent RNA helicase p62 (Rm62), partial

  • 中文名稱：
    黑腹果蠅Rm62重組蛋白
  • 貨號(hào)：
    CSB-YP322496DLU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Rm62重組蛋白
  • 貨號(hào)：
    CSB-EP322496DLU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Rm62重組蛋白
  • 貨號(hào)：
    CSB-EP322496DLU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Rm62重組蛋白
  • 貨號(hào)：
    CSB-BP322496DLU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Rm62重組蛋白
  • 貨號(hào)：
    CSB-MP322496DLU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rm62
  • Uniprot No.：
  • 別名：
    Rm62; Dmp68; p62; CG10279; ATP-dependent RNA helicase p62; EC 3.6.4.13
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, rRNA processing and miRNA processing, as well as transcription regulation. Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner.
  • 基因功能參考文獻(xiàn)：
    1. Through an RNAi screen in Drosophila cells, study identified Rm62 as an anti-RVFV helicase gene. Rm62 is also essential for resistance to RVFV infection in vivo, as RVFV-challenged Rm62-deficient flies showed increased viral replication and mortality. PMID: 25126784
    2. RNA helicase interacts with the well-characterized histone methyltransferase SU(VAR)3-9 via its N-terminus, which provides a potential mechanism for the targeting of H3K9 methylation to highly regulated genes. PMID: 21674064
    3. Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos PMID: 20196121
  • 亞細(xì)胞定位：
    Nucleus. Nucleus, nucleolus. Cytoplasm, cytosol.
  • 蛋白家族：
    DEAD box helicase family, DDX5/DBP2 subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG10279

    STRING: 7227.FBpp0078301

    UniGene: Dm.1520