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  4. Recombinant Drosophila melanogaster Voltage-dependent calcium channel type A subunit alpha-1 (cac), partial

Recombinant Drosophila melanogaster Voltage-dependent calcium channel type A subunit alpha-1 (cac), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Voltage-dependent calcium channel type A subunit alpha-1(cac) ,partial,Yeast
  • 貨號：
    CSB-YP310084DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Voltage-dependent calcium channel type A subunit alpha-1(cac) ,partial,Yeast
  • 貨號：
    CSB-EP310084DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Voltage-dependent calcium channel type A subunit alpha-1(cac) ,partial,Yeast
  • 貨號：
    CSB-EP310084DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Voltage-dependent calcium channel type A subunit alpha-1(cac) ,partial,Yeast
  • 貨號：
    CSB-BP310084DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Voltage-dependent calcium channel type A subunit alpha-1(cac) ,partial,Yeast
  • 貨號：
    CSB-MP310084DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    cac
  • Uniprot No.：
  • 別名：
    cac; nbA; nonB; CG43368; Voltage-dependent calcium channel type A subunit alpha-1; Protein cacophony; Protein nightblind A; Protein no-on-transient B; Dmca1A
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death. Probably encodes a dihydropyridine-insensitive current. Vital for survival to adulthood.
  • 基因功能參考文獻(xiàn)：
    1. Motor defects in TDP-43 mutants can be rescued by expression of cacophony in motor neurons and by expression in two pairs of neurons in the brain. PMID: 28847811
    2. the novel R1673P allele of CACNA1A produces neurodegenerative phenotypes in flies and human, likely due to a toxic gain of function PMID: 28742085
    3. cacophony (cacTS2), a mutation of the Drosophila presynaptic Ca++ channel alpha1 subunit gene, is a particularly potent seizure-suppressor mutation, reverting seizure-like phenotypes for parabss1 and other BS mutants PMID: 26771829
    4. Cac regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PMID: 25811491
    5. Homeostatic depression is achieved by decreased presynaptic Cav2.1 calcium channel abundance and calcium influx. PMID: 25884248
    6. Dopaminergic neurons with mutant Ca2+ channel cacophony are inherently resistant to MPP+-induced neurodegeneration. PMID: 25445363
    7. cac and Dmca1D Ca(2+) channels differentially contribute to functional and structural aspects of slo-induced synaptic modifications PMID: 23959639
    8. Vesicle exocytosis depends on cacophony, TRP and TRPL. PMID: 22952921
    9. Homeostatic increase in Ca(2+) influx and release is blocked by a point mutation in the presynaptic CaV2.1 channel. PMID: 22633807
    10. role of mutation in courtship and other behaviors PMID: 12242229
    11. Dmca1A is an allele of the N-type calcium channel locus that caused synaptic undergrowth PMID: 12896973
    12. Localization of cacophony on presynaptic terminals at neuromuscular synapses. PMID: 14715960
    13. Data show that the Drosophila cacophony ts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation PMID: 16820014
    14. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic Ca(V)2.1 in a homeostatic retrograde signaling system. PMID: 17114050
    15. Cacophony protein plays a key role in developmental regulation of Drosophila neuronal excitability. PMID: 17267561
    16. Neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the alpha(2)delta Ca(2+) channel subunit in mediating the proper localization of an alpha(1) subunit at synapses. PMID: 18391075
    17. cac encoded Ca(v)2-type calcium channels regulate action potential (AP)-independent release of neurotransmitter at excitatory cholinergic synapses PMID: 19004991

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family
  • 組織特異性：
    Expressed widely in the embryonic nervous system.
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG43368

    STRING: 7227.FBpp0298326

    UniGene: Dm.2395