Recombinant Human Alpha-adducin (ADD1)
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中文名稱:Recombinant Human Alpha-adducin(ADD1),Yeast
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貨號:CSB-YP001348HU
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規(guī)格:
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來源:Yeast
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其他:
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中文名稱:Recombinant Human Alpha-adducin(ADD1),Yeast
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貨號:CSB-EP001348HU
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規(guī)格:
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來源:E.coli
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其他:
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中文名稱:Recombinant Human Alpha-adducin(ADD1),Yeast
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貨號:CSB-EP001348HU-B
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規(guī)格:
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來源:E.coli
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共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名稱:Recombinant Human Alpha-adducin(ADD1),Yeast
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貨號:CSB-BP001348HU
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規(guī)格:
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來源:Baculovirus
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其他:
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中文名稱:Recombinant Human Alpha-adducin(ADD1),Yeast
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貨號:CSB-MP001348HU
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規(guī)格:
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來源:Mammalian cell
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其他:
產(chǎn)品詳情
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純度:>85% (SDS-PAGE)
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基因名:ADD1
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Uniprot No.:
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別名:ADD A; ADD1; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha; MGC3339; MGC44427; OTTHUMP00000151163; OTTHUMP00000151164; OTTHUMP00000151165; OTTHUMP00000218664; OTTHUMP00000218665
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種屬:Homo sapiens (Human)
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蛋白長度:Full length protein
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表達區(qū)域:1-737
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氨基酸序列MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK KFRTPSFLKK SKKKSDS
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蛋白標簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
相關(guān)產(chǎn)品
靶點詳情
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功能:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
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基因功能參考文獻:
- alpha-adducing SNPs were not associated with bone density among lead workers. PMID: 29028685
- These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders. PMID: 28686109
- The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island. PMID: 29049185
- ZNF322A overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis PMID: 26279304
- ADD1 rs4963 polymorphism showed an increased hypertension risk. PMID: 28040068
- This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus. PMID: 27340988
- study shows that the a-adducin G460T polymorphism is associated with essential hypertension PMID: 27349000
- Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC) suggesting an association between ADD1 and CRC risk. PMID: 25816007
- The T allele of ADD1 is associated with essential hypertension in Asians. PMID: 26042478
- study of potential effects of interaction between DNA methylation of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation of ADD1 gene promoter have a significant role in modifying EH susceptibility PMID: 25567773
- There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism. PMID: 25262176
- A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample. PMID: 24718403
- When alpha-adducin complexes with sodium potassium ATPase in astrocytes, non-cell autonomous neurodegeneration is triggered. PMID: 25344630
- Data indicate that adducin promotes adhesion by regulating desmosomes and is part of a protective pathway in pemphigus. PMID: 24711455
- Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10). PMID: 24379415
- Fnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer. PMID: 23985264
- concentration of AST was inversely correlated with ADD1 CpG2-5 methylation levels in female controls. These observations may bring new hints to elaborate the pathogenesis of essential hypertension PMID: 23691048
- study is the first meta-analysis to evaluate the influences of ACE and ADD1 polymorphisms on blood pressure responses to hydrochlorothiazide to combine the inconsistent results of previous studies PMID: 23863317
- the rs4963 polymorphism within ADD1 gene is associated with essential hypertension in the Chinese population PMID: 23509723
- role of ADD1 gene polymorphism in hypertension PMID: 22810272
- there was no association of ACE and ADD1 gene polymorphism in ischaemic stroke patients PMID: 23540412
- genotype and allele frequencies of ACE and ADD1 polymorphisms were compared between patients and controls as well as between ischemic stroke and ICH PMID: 21194526
- Hypertension-linked mutation of alpha-adducin increases CFTR surface expression and activity in HEK and cultured rat distal convoluted tubule cells. PMID: 23284854
- Variant genotype combinations of ACE and alphaADDUCIN render the hypertensive patient more vulnerable to recurrent intracerebral hemorrhage PMID: 22198647
- genetic variants of the ADD1 and GNB3 genes may have important roles in blood pressure response to the cold pressor test PMID: 22476228
- organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin PMID: 22163289
- The alpha-adducin Gly460Trp gene polymorphism might modulate renal function decline in the Chinese. PMID: 22677360
- Findings support a role for alpha-adducin in memory from nematodes to humans. PMID: 22307086
- Data show that alpha-adducin G460W gene polymorphism was linked to essential hypertension (EH) susceptibility. PMID: 22272309
- Further studies involving siRNA-mediated knockdowns of spectrin, adducin, or p4.1 revealed that those proteins are needed for efficient docking of enterohaemorrhagic Escherichia coli to host cells. PMID: 22197999
- the mechanism for alpha-adducin to shuttle between the cytoplasm and nucleus; a potential role for alpha-adducin in mitosis. PMID: 21736685
- In the studied Russian population G460W polymorphism of ADD1 gene can be considered as predisposition gene to hypertension, but its pathological effect is manifested solely under influence of environmental factors. PMID: 22117679
- Null association of alpha-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese, but local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese. PMID: 21364877
- this meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese. PMID: 21228790
- ADD1 variant genotypes were not associated with increased risk but in association with ACE DD genotype resulted in significantly higher risk of PSICH. ACE and ADD1 variant genotypes were associated with nonlobar hematoma. PMID: 21339657
- These findings suggest novel roles for adducins in stabilization of epithelial junctions and regulation of junctional remodeling. PMID: 20810786
- Alpha-adducin Gly460Trp polymorphism is associated with hypertension. PMID: 20927398
- Genetic variration in alpha adducion alter renal function and/or vasoreactivity are logical candidates to explain some of the individual variability in the blood pressure response to exercise. PMID: 20929695
- Although the effect of both genetic variants on CIMT was small, this study showed a statistically significant effect of AGTR1 and ADD1 in women PMID: 19620885
- The alpha-adducin gene G460W polymorphism was not associated with hypertension in either a case-control study of essential hypertension in Shangha residents or in a meta-analysis of all reports in English. PMID: 19960031
- ALPHA AND BETA ADDUCIN POLYMORPHISMS AFFECT DECLINE OF RENAL FUNCTION IN HUMAN IGA NEPHROPATHY. PMID: 19838659
- Alpha-adducin Gly460Trp polymorphism is associated with salt-sensitivity. PMID: 20145305
- The alpha-adducin G614T polymorphism is associated with the antihypertensive effect of hydrochlorothiazide. PMID: 16266470
- effects of environmental, demographic, & genetic factors & their interactions to SBP response to antihypertensive drugs, explained 23% of the total variance. Ethnicity, low sodium intake, & ADD1 614G-->T polymorphism were the only drug-related predictors PMID: 19779464
- Role of the alpha-adducin genotype on renal disease progression. PMID: 11918733
- interaction between diuretic therapy and the adducin variant on the incidence of myocardial infarction and stroke PMID: 11926892
- ADD1 460W allele associated with cardiovascular disease in hypertensive individuals PMID: 12052841
- Blood pressure in patients with primary aldosteronism is influenced by alpha-adducin gene polymorphisms. PMID: 12107246
- Carotid and femoral intima-media thickness were assessed in subjects genotyped for the presence of the ACE D, aldosterone synthase -344T and alpha-adducin 460Trp alleles. PMID: 12172317
- Patients homozygous for the allele of that polymorphism had a LV mass index significantly higher compared with heterozygotes or homozygotes. These subjects also have significantly lower plasma renin activity. PMID: 12195118
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亞細胞定位:Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族:Aldolase class II family, Adducin subfamily
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組織特異性:Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
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