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  4. Recombinant Human Protein S100-P (S100P)

Recombinant Human Protein S100-P (S100P)

  • 中文名稱：
    人S100P重組蛋白
  • 貨號：
    CSB-EP020645HU
  • 規(guī)格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    S100P
  • Uniprot No.：
  • 別名：
    Migration-inducing gene 9 protein;MIG9;Protein S100-E;S100 calcium-binding protein P
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    17.4 kDa
  • 表達區(qū)域：
    1-95aa
  • 氨基酸序列
    MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
  • 基因功能參考文獻：
    1. Data suggest that analysis of S100P concentration in duodenal fluid (DF), in combination with routine screening upper gastrointestinal endoscopy (GIE), may facilitate the detection of pancreatic ductal adenocarcinoma (PDAC). PMID: 28984789
    2. Data show that inhibition of S100 calcium binding protein P (S100P) results in reversing trastuzumab resistance (TzR) in proto-oncogene protein HER-2 (HER2)-driven breast cancers. PMID: 27449296
    3. the S100P protein may contribute to the outgrowth of aggressive tumor cells resistant to cytotoxic therapy and promote cancer progression. PMID: 26967060
    4. Results found high plasma levels of S100P protein in patients with metastatic breast cancer which suggest its implication in disease progression. PMID: 27146585
    5. activation of tissue plasminogen activator via the C-terminal lysine of S100P contributes to the enhancement of cell invasion by S100P and thus potentially to its metastasis-promoting activity. PMID: 28798096
    6. This study reveals significant association between blood-based decreased S100P methylation and Breast cancer (BC), and provides another proof for the application of altered DNA methylation signatures from blood cells as potential markers for the detection of BC, especially for the early stage. PMID: 28426874
    7. Novel positive feedback loop between Trx-1 and S100P promotes colorectal cancer invasion and metastasis. PMID: 28483515
    8. An S100P-positive biliary epithelial field is a preinvasive intraepithelial neoplasm in nodular-sclerosing cholangiocarcinoma. PMID: 27984121
    9. We established a novel quantitative analysis for the S100P protein in EUS-FNA samples which, when combined with EUS-FNA cytology, could provide promising results for the reliable diagnosis of pancreatic adenocarcinoma (PCA) PMID: 28260012
    10. S100P achieved 96.4% sensitivity, 93.3% specificity, 98.2% PPV, 87.5% NPV and 95.8% total accuracy, while IMP3 achieved 91.2% sensitivity, 86.7% specificity, 96.2% PPV, 72.2% NPV and 90.3% total accuracy for pancreatic ductal adenocarcinoma (PDA).Both markers were sensitive and specific for diagnosis of PDA. PMID: 27839709
    11. we demonstrate that cadmium inhibits S100P expression and cell proliferation in placenta, meanwhile, S100P expression affects cell proliferation PMID: 27665374
    12. Results indicate that overexpression of S100P is related with an invasive and metastatic phenotype of CRC which is EMT-involved and RAGE dependent. PMID: 26975699
    13. S100P in first trimester placenta was significantly less in spontaneous abortion patients than in normal pregnant women. Up-regulation of S100P in JAR cells promoted JAR cells proliferation, and increased the expression of p38 MAPK and pERK MAPK PMID: 26291820
    14. Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. PMID: 26320193
    15. Keap1 functions as a suppressor of tumor metastasis by targeting the Nrf2/S100P pathway in NSCLC cells. PMID: 26078391
    16. Results suggest that SOX9 promotes tumor metastasis and invasion through regulation of S100P expression in colon cancer. PMID: 26009899
    17. LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway. PMID: 26797416
    18. The highly specific IL-11 - S100P interaction occurring under physiologically relevant conditions should be taken into consideration upon development of the antineoplastics inhibiting IL-11 signaling. PMID: 26551460
    19. S100P expression in prostate cancer tissue was significantly decreased, whereas CD147 and OCT4 expression was increased. Their expression levels were closely associated with TNM stage and distant metastasis. PMID: 26125892
    20. t-S100P, 9.2-kDa C-terminally truncated form of S100P, is the predominant form of S100P in breast cancer tissue and is strongly prognostic for disease-free survival in women with lymph node-positive disease. PMID: 26276712
    21. S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells PMID: 26193421
    22. High expression of S100P and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P and HYAL2 could be potential prognostic markers of TNBC. PMID: 26112095
    23. upregulation of S100P expression is a predominant characteristic in polypoid CRC, whereas ulcerative CRC presents with a wide range of expression levels, indicating that S100P overexpression is not a key determinant in conferring invasion properties PMID: 25585623
    24. B-cell lymphoma/leukemia 10 promotes oral cancer progression through STAT1/ATF4/S100P signaling pathway. PMID: 24681956
    25. S100P may promote endometrial tumor cell proliferation by increasing nuclear translocation of beta-catenin. PMID: 24966918
    26. The results suggest that S100P acts as an oncogenic factor in gastric cancer and is a potential molecular target for gastric cancer gene therapy. PMID: 24677114
    27. The current evidence suggests that S100P plays an important role in the diagnosis of Pancreatic cancer with a high sensitivity and specificity [review] PMID: 25123266
    28. The expression of S100P in human gastric cancer tissues was upregulated in comparison with normal controls. PMID: 23722300
    29. Ectopic expression of S100P promotes SW480 cancer cells migration. PMID: 24381058
    30. Use of S100P and mesothelin in cytologically borderline cases can increase the diagnostic accuracy for pancreatic adenocarcinoma. PMID: 21538952
    31. Expression levels significantly higher in melanomas than in nevus pigmentosus PMID: 24303922
    32. S100P expression is a novel prognostic factor in hepatocellular carcinoma and predicts survival in patients with high tumor stage or early recurrent tumors. PMID: 23785431
    33. S100P participates in the periodic change of the endometrium and plays an important role in embryo implantation. PMID: 23216986
    34. S100P protein , human is useful as prognostic marker for extrahepatic bile duct carcinoma. PMID: 23269460
    35. The expression of miR-155 is regulated by S100P and is dependent on RAGE activation and stimulation of AP-1. PMID: 23693020
    36. Demonstrate that a high nuclear S100P expression level was associated with poor survival in early stage breast cancer patients. PMID: 23364898
    37. S100P facilitates cancer cell intravasation/extravasation, critical steps in the hematogenous dissemination of pancreatic cancer cells PMID: 23007696
    38. colorectal cancer patients with normal serum levels of S100P showed favorable prognosis compared with patients with elevated S100P levels PMID: 22552710
    39. This study investigates whether there is a correlation of expression of S100P and von Hippel-Lindau gene product (pVHL) in common cystic neoplasms of the pancreas. PMID: 22585604
    40. Data show wthat the S100P-induced dissociation of NMIIA filaments leads to a weakening of focal adhesion sites (FAS), reduced cell adhesion, and enhanced cell migration, the first major step in the metastatic cascade. PMID: 22399300
    41. investigation of expression of S100P, S100A4, and AGR2 at cellular level within endometrium of normal fertile women across menstrual cycle and comparison with expression in eutopic and peritoneal ectopic endometrial tissue in endometriosis PMID: 22147918
    42. data suggest that S100P is a direct transcriptional target of glucocorticoid-mediated signaling in tumor cells that is activated through the interplay of GR and MAPK pathways PMID: 21751241
    43. Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA, all potential therapeutic targets in cancer. PMID: 21327297
    44. Our results suggest that S100P-ezrin signaling has different roles of carcinogenesis of perihilar ICC and an aggressive course of peripheral intrahepatic cholangiocarcinoma. PMID: 21412073
    45. The 5-year cumulative survival rate of patients with positive S100P expression was significantly higher than that of patients with negative expression. PMID: 21054985
    46. S100P is a novel Ca(2+)-dependent regulator of IQGAP1 that can down-regulate the function of IQGAP1 as a signaling intermediate by direct interaction PMID: 21177863
    47. S100P has slightly lower sensitivity and higher specificity of pancreatic ductal adenocarcinoma than XIAP in endoscopic ultrasound-guided fine needle aspirations specimens. PMID: 21325798
    48. S100P may play an important role in malignant transformation of ductal cells of pleomorphic adenoma PMID: 21317706
    49. High S100p is associated with colon cancer. PMID: 20890108
    50. S100P is highly expressed during the implantation window in human endometrium. PMID: 19796763

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
  • 蛋白家族：
    S-100 family
  • 組織特異性：
    Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial n
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10504

    OMIM: 600614

    KEGG: hsa:6286

    STRING: 9606.ENSP00000296370

    UniGene: Hs.2962