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  4. Recombinant Human Sorbin and SH3 domain-containing protein 2 (SORBS2), partial

Recombinant Human Sorbin and SH3 domain-containing protein 2 (SORBS2), partial

In Stock
  • 中文名稱(chēng)：
    人SORBS2重組蛋白
  • 貨號(hào)：
    CSB-EP022405HU
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    SORBS2
  • Uniprot No.：
  • 別名：
    (Arg-binding protein 2)(ArgBP2)(Arg/Abl-interacting protein 2)(Sorbin)
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 來(lái)源：
    E.coli
  • 分子量：
    33.1 kDa
  • 表達(dá)區(qū)域：
    863-1100aa
  • 氨基酸序列
    KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
  • 基因功能參考文獻(xiàn)：
    1. By enhancing the stability of gene transcripts, SORBS2 suppresses ovarian cancer invasiveness and affects monocyte to myeloid-derived suppressor cell and M2-like macrophage polarization, eliciting a tumor-suppressive immune microenvironment. PMID: 29548303
    2. results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells. PMID: 29339121
    3. In spite of our finding that SORBS2 is clearly a component of the apical junction complex, it does not appear to be required for either normal tight- or adherens junction assembly, structure or function or for growth factor-mediated changes in tight junction dynamics PMID: 28961272
    4. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy PMID: 26359233
    5. ArgBP2 inhibits proliferation, migration, and invasion of gastric cancer cells.MORC2 down-regulates the ArgBP2 via histone methylation in gastric cancer cells. PMID: 26476214
    6. This study confirmed that SORBS2 as genetic modifiers of age at onset of Alzheimer disease. PMID: 26214276
    7. ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration PMID: 25429109
    8. Tyrosine phosphorylation of ARGBP2 interferes with a SH3 mediated self-interaction, thereby controlling its panel of interacting partners and related functions. PMID: 24475245
    9. SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes. PMID: 24165198
    10. Sarcoplasmic sorbin and SH3 domain-containing protein 2 is released from damaged cardiac tissue into the bloodstream upon lethal acute myocardial infarction. PMID: 24342996
    11. the expression and localization of hArgBP2 in osteosarcoma MG-63 cells PMID: 22394629
    12. In epithelial NMuMG cells, immunofluorescence analyses revealed localization of ArgBP2 at tight junctions and mutation analyses found a second SH3 domain to be important for ArgBP2 localization to the cell-cell contact sites. PMID: 22431180
    13. A co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. PMID: 21689717
    14. Reconstitution of SORBS2 expression resulted significant reduction in cell proliferation, colony formation and anchorage-independent growth in CaSki, HPKII and HaCaT cells, whereby anchorage-independent growth could only be investigated for CaSki cells PMID: 21602178
    15. Results indicate that ArgBP2 may play an important role in the assembly and maintenance of myofibrils in cardiomyocytes. PMID: 20886612
    16. CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration. PMID: 19631450
    17. complexation with Cbl mediates ubiquitination and degradation of c-Abl PMID: 12475393
    18. regulates cytoskeletal organization and signal transduction--review PMID: 12510380
    19. The sorbin N- and C-termini were localized in the human ArgBP2 gene locus; they are spliced to the 5' and 3' ends of the 95% homologous region; thus, a revised human sorbin nucleotide sequence is proposed. PMID: 15949647
    20. Loss of ArgBP2 is associated with pancreatic cancer. PMID: 18559503

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  • 亞細(xì)胞定位：
    Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium.
  • 組織特異性：
    Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the panc
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24098

    OMIM: 616349

    KEGG: hsa:8470

    STRING: 9606.ENSP00000284776

    UniGene: Hs.481342