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  4. Recombinant Human Toll-like receptor 3 (TLR3), partial

Recombinant Human Toll-like receptor 3 (TLR3), partial

  • 中文名稱：
    人TLR3重組蛋白
  • 貨號：
    CSB-YP023602HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TLR3重組蛋白
  • 貨號：
    CSB-EP023602HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TLR3重組蛋白
  • 貨號：
    CSB-EP023602HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TLR3重組蛋白
  • 貨號：
    CSB-BP023602HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TLR3重組蛋白
  • 貨號：
    CSB-MP023602HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CD283; CD283 antigen; IIAE2; TLR 3; Tlr3; TLR3_HUMAN; Toll Like Receptor 3; Toll-like receptor 3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
  • 基因功能參考文獻(xiàn)：
    1. study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE2 secretion via the COX-2/PGE2 pathway. PMID: 29273868
    2. We report a significant association between TLR3 L412F and persistent clinical disease in two cohorts of Irish and American Caucasians with pulmonary sarcoidosis. This study identifies defective TLR3 function as a previously unidentified factor in persistent clinical disease in pulmonary sarcoidosis and reveals TLR3 L412F as a candidate biomarker. PMID: 29237089
    3. Data indicate that trigeminal ganglion (TG) neurons are vulnerable to HSV-1 because they require preemptive stimulation of the Toll-like receptor 3 (TLR3) to induce antiviral immunity. PMID: 30154162
    4. These variations in the TLR3mediated signaling pathway molecules suggested that oxidative stress may be a key regulator for TLR3 activation during RSV infection PMID: 29845280
    5. In conclusion, we demonstrated that EV71 infection induced elevated expressions of TLR3/4 and Notch1/2 in CD14+ monocytes. PMID: 29702280
    6. Increased TLR3 expression in acute exacerbations of chronic obstructive pulmonary disease patients is associated with declining lung function PMID: 29264743
    7. Data show that regenerating family member 3 alpha protein (REG3A) can modulate specific cutaneous inflammatory responses and that the decrease in cutaneous REG3A exacerbates toll-like receptor 3 (TLR3)-mediated inflammation in diabetic skin wounds. PMID: 27830702
    8. These data indicate a novel role of the TLR3-TICAM-1 pathway in controlling miR-21 levels in extracellular vesicles. PMID: 29679565
    9. The TLR3.rs3775290 "CC" genotype was associated with hepatitis C virus chronicity, while the TLR9 gene may not play a major role in hepatitis C virus infection. PMID: 29860675
    10. CYLD inhibits post-transcriptional regulation of RIG-I and MDA5 expression following TLR3 activation in MCs. CYLD may be involved in the pathogenesis of CKD PMID: 29166644
    11. These results demonstrate that histamine up-regulates the expression of TLR3 and secretion of IL-13 and MCP-1 in mast cells, thus identifying a new mechanism for the histamine inducing allergic response. PMID: 29742501
    12. Reduced response of NK cells to TLR3 stimulation in children with recurrent infections has been observed. PMID: 29975469
    13. Using hepatocyte-based culture models for Hepatitis C virus (HCV) infection, we found a portion of HCV dsRNA intermediates to be released from infected cells in extracellular vesicles, which reduces activation of toll-like receptor 3. PMID: 29535029
    14. the association between TLR3, TLR4 variants and nine IL-6 polymorphisms, and response to anti-viral treatment during hepatitis C infection. PMID: 28823914
    15. results suggest that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis. PMID: 27031066
    16. The current study suggests that TLR3 signaling induces CCL5 expression via NF-kappaB and IRF3 in bile duct cells, and this pathway may be involved in the pathogenesis of BA. PMID: 29070776
    17. The down regulation of TRIF, TLR3, and mitochondrial antiviral signaling protein (MAVS) expressions in chronic hepatitis C correlates with the disease severity and the outcome of hepatitis C virus infection PMID: 28480979
    18. this study signifies that TLR3 adaptor molecules are necessary for the proper production of cytokines, chemokines and pro-labour mediators after TLR ligation PMID: 28844021
    19. we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity. PMID: 27270888
    20. Increased expressions of TLR-3, TLR-4 and CD80 mRNA and the level of urinary CD80/creatinine could be useful markers to differentiate patients of steroid-sensitive nephrotic syndrome in relapse from those with steroid-resistant nephrotic syndrome. PMID: 28210837
    21. TRIM56 may act as a tumor suppressor in multiple myeloma through activation of TLR3/TRIF signaling pathway. PMID: 29214775
    22. p53 mutants that retain the ability to transactivate TLR3, can be used together with the TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C) to alter immune responses mediated by this receptor, and subsequently increase TLR3-mediated apoptosis PMID: 27533082
    23. Positive rates of iNOS in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3, TLR4, TLR7, TLR8, NF-kappaB p65, and iNOS in cervical epithelial cells were higher in CC group than in other groups. PMID: 28626766
    24. TLR signaling, in particular TLR3 activation, can efficiently reactivate HIV transcription in infected microglia, but not in monocytes or T cells PMID: 28166799
    25. TLR3 stimulation induces the Warburg effect in head and neck squamous carcinoma cells in vitro, and suggest that TLR3 may play a role in tumor adaptation to hypoxia. PMID: 27791989
    26. we report that autophagy is associated with apoptosis processes, involving LC3 and TRIF-colocation in human HCC cells. Regulation of autophagy and the TLR3-TRIF pathway may be effective in the treatment of liver cancer. PMID: 27338037
    27. Polymorphism of CD209 and TLR3 genes in populations of North Eurasia PMID: 29368829
    28. TLR3-activated signaling enhanced the therapeutic effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of colitis PMID: 27649928
    29. the TLR3 Leu412Phe CC genotype is independently associated with severity of hepatitis C recurrence after LT. PMID: 27101936
    30. These data demonstrate that in the absence of HBsAg, hepatic hepatitis B virus replication leads to Tlr3-dependent interferon responses in non-parenchymal liver cells. PMID: 27121087
    31. Study found that the astrocytic TLR3-mediated cytokine expression profile is modulated by prostaglandin, and NF-kappaB, ERK1/2 and GSK-3beta are involved in the modulatory mechanism. These results suggest that pathological conditions with increased COX activity can neuroimmunologically alter neuron-glia interaction. PMID: 25014275
    32. Activation of TLR3 and TLR4 stimulated the expression of HIF-1 through NF-kappaB in oral squamous cell carcinoma PMID: 27191981
    33. The present study investigated the effects of vitamin D3 on the expression of TLR3, TLR7, and TLR9 in Systemic lupus erythematosus patients. PMID: 28544067
    34. TLR3 or TLR4 activation of mesenchymal stem cells increases Treg cell induction via the Notch pathway PMID: 27571579
    35. Data suggest that, unlike non-metastatic intestinal epithelial cells (IECs), metastatic IECs express TLR3 and that TLR3 agonists induce inflammatory cytokine (CXCL10) production and promote invasiveness of IECs. (TLR3 = toll-like receptor 3; CXCL10 = chemokine [C-X-C motif] ligand 10 protein) PMID: 28717003
    36. TLR3-activated macrophages release exosomes that contain anti-HCV microRNA (miRNA)-29 family member PMID: 27605546
    37. homozygous IFITM3 CC and TLR3 CC genotypes showed significant independent associations with higher death risks in H7N9/H1N1pdm09 influenza in a large Chinese cohort PMID: 28510725
    38. TLR3 activation can induce metabolic reprogramming in a pharyngeal cancer cell line, leading to increased aerobic glycolysis, cell migration, elevated levels of reactive oxidative species (ROS), and decreased anti-oxidative response. PMID: 27805282
    39. Ligand-driven triggering of TLR-3, -4, NOD2, and DC-SIGN, despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells. PMID: 28266028
    40. Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1), RIP1, and IRAK1, we hypothesize that SH exerts its NF-kappaB activation inhibitory function by interacting with TNFR1, interleukin-1 receptor type 1 (IL-1R1), and TLR3 complexes in the plasma membrane of infected cells. PMID: 28659487
    41. Primary tumor-derived exosomal RNAs, which are enriched in small nuclear RNAs, activate TLR3 in lung epithelial cells, consequently inducing chemokine secretion in the lung and promoting neutrophil recruitment. PMID: 27505671
    42. the L412F polymorphism in the TLR3 gene could be a genetic risk factor for the development of human cytomegalovirus disease PMID: 28046022
    43. Studied Toll-like receptor 3 (TLR3) mutations in a cohort of 11 adult Italian viral encephalitis patients. PMID: 28368532
    44. This study concluded that M. catarrhalis reduces antiviral defense functions of bronchial epithelial cells, which may increase susceptibility to viral infections. PMID: 26979086
    45. Report PD-1/PD-L1 and TLR3 expression in malignant pleural mesotheliomas as possible tests for selection patients who could benefit from immunotherapy. PMID: 26980049
    46. LUBAC components control TLR3-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation. PMID: 27810922
    47. found that TLR3 signaling induces the expression of IFI35, and IFI35 negatively regulates IFN-beta-P-STAT1-RIG-I-CXCL10/CCL5 axis in U373MG cells. This suggests that IFI35 expressed in astrocytes may play an important role in regulating the innate immune system in astrocytoma cells. PMID: 28109979
    48. COPD lung tissue explants showed a greater pro-inflammatory response to TLR3 or TLR7/8 activation than control smokers. PMID: 27729782
    49. frequency of TLR3 c.1377 TT homozygous mutant genotype in the Crimean-Congo hemorrhagic fever (CCHF) patients was higher than that of the healthy controls in the clinical settings; in conclusion, presence of TLR3 c.1377 TT genotype may have a role in the susceptibility to CCHF PMID: 26959380
    50. TLR-3 c.1377 T-allele was associated with advanced stage of hepatic fibrosis in Egyptian patients. Frequency of polymorphic genotypes in TLR-3 (_7 C/A), TLR-3 (c.1377C/T) and TLR-9 (1237T/C) were not significantly different between studied HCV-positive patients and controls. PMID: 28093541

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  • 相關(guān)疾?。?/div>
    Herpes simplex encephalitis 2 (HSE2)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome.
  • 蛋白家族：
    Toll-like receptor family
  • 組織特異性：
    Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain,
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11849

    OMIM: 603029

    KEGG: hsa:7098

    STRING: 9606.ENSP00000296795

    UniGene: Hs.657724