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  4. Recombinant Human Tryptophan 5-hydroxylase 1 (TPH1)

Recombinant Human Tryptophan 5-hydroxylase 1 (TPH1)

  • 中文名稱：
    人TPH1重組蛋白
  • 貨號：
    CSB-YP024100HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TPH1重組蛋白
  • 貨號：
    CSB-EP024100HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TPH1重組蛋白
  • 貨號：
    CSB-EP024100HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TPH1重組蛋白
  • 貨號：
    CSB-BP024100HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TPH1重組蛋白
  • 貨號：
    CSB-MP024100HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TPH1
  • Uniprot No.：
  • 別名：
    Indoleacetic acid 5 hydroxylase; L tryptophan hydroxylase; MGC119994; TPH 1; TPH; TPH1; TPH1_HUMAN; TPRH; TRPH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; Tryptophan hydroxylase 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-444
  • 氨基酸序列
    MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES RKSKRRNSEF EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED GMETVPWFPK KISDLDHCAN RVLMYGSELD ADHPGFKDNV YRKRRKYFAD LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE LNKLYPTHAC REYLKNLPLL SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD FLSGLAFRVF HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK VKPFDPKITC KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK YNPYTRSIQI LKDTKSITSA MNELQHDLDV VSDALAKVSR KPSI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
  • 基因功能參考文獻：
    1. These findings indicate that TPH1, TPH2, and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants. PMID: 28590957
    2. TPH-1 is overexpressed in remodeled pulmonary arteries of patients with idiopathic Pulmonary Arterial Hypertension . PMID: 28582316
    3. Elderly Croatian Suicide completers, but not younger Suicide completers (below 65 years old), had higher frequencies of the CC genotype of polymorphisms localized in intron 7 of Typtophane Hydroxylase (TPH1) gene. PMID: 26743828
    4. These results suggested that silencing of androgen/androgen receptor signaling may cause initiation and progression of seminomas through increase in TPH1 gene expression level. PMID: 27144435
    5. The catalytic domain of TPH1 shares a sequence identity of 81% with TPH2. Despite the high sequence identity, differences in the kinetic parameters of the isoforms have been identified; i.e., only TPH1 displays substrate tryptophan inhibition. PMID: 29035515
    6. results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior. PMID: 27479537
    7. Tryptophan Hydroxylase 1 Variant rs1800532 is associated with Suicide Attempt in Serbian Psychiatric Patients. PMID: 27037949
    8. This study demonstrates that both TPH1 and TPH2 are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development. PMID: 28751217
    9. Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations. Investigated A218C polymorphism in 109 suicide attempters and 98 healthy controls. Our results provide evidence that A allele of TPH1 A218C polymorphism may be associated with suicidal behavior in Turkish population PMID: 27497328
    10. The regulatory domain of isoform 1 of tryptophan hydroxylase was expressed and purified; mutagenesis of Cys64 was required to prevent formation of disulfide-linked dimers. PMID: 27255998
    11. Associations between serotonin transporter gene and tryptophan hydroxylase 1 polymorphisms and several Temperament and Character Inventory dimensions and subdimensions were revealed in subjects with bipolar disorder. PMID: 27573591
    12. there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent, but not in alcohol-dependent patients. PMID: 27045756
    13. Polymorphisms in the TPH1 gene may be represented by diminished activity in lateral areas of the PFC underlying response inhibition. PMID: 26710093
    14. Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts PMID: 26238767
    15. TPH1 is functionally expressed in human coronary artery smooth muscle cells. PMID: 25861735
    16. This review showed no evidence for the association of antidepressant response with an A218C SNP in the TPH1 gene. PMID: 25419635
    17. The study provides evidence that A218C/A779C TPH-1 variants may be a risk factor to manifest suicidal behavior at the clinical level, which is in agreement with previously reported meta-analyses.[review and meta-analysis] PMID: 25005534
    18. TPH1 gene polymorphisms and S100A10 expression, which correlate with 5-HT signaling were associated with ramosetron effectiveness in IBS-D, and may possibly lead to prospective identification of the resistance to treatment. PMID: 25428414
    19. no significant effects on group differences or effects of exercise interventions for most of the biological parameters, that is, IL-6, neopterin, 5-HIAA and tryptophan PMID: 24140252
    20. Tph1 and increased EC cell number occurred before the onset of obesity and hyperleptinemi. In addition, leptin deficiency was associated with reduced Pax4 mRNA, oral leptin treatment enhanced both Tph1 and Pax4 mRNA. PMID: 24468700
    21. TPH1 gene polymorphism rs1800532 C>A is associated with the risk of paranoid schizophrenia in Russians and Tatars. PMID: 25842846
    22. Results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression PMID: 24903772
    23. HTTLPR may mediate the risk for SMB through modulation of some temperamental traits. PMID: 24280759
    24. None of the genetic markers within SLC6A4, MAOA, TPH1 and TPH2 were significantly associated with completed suicide or suicide method in the basic association tests. PMID: 23313272
    25. results suggest that patients' perception of their illness, and of the impact it has on their lives, may be subject to genetic influences, in this case sequence variants in TPH1 PMID: 23172723
    26. The TPH1 promoter SNP -347C/A differentially binds EGR-1 and correlates with IBS bowel habit subtypes and possibly colonic TPH1 expression consistent with its role in modulating intestinal 5-HT signaling. PMID: 24060757
    27. These results cannot provide support for an important function of TPH1 and HTR1B in the pathogenesis of sclerosing bone dysplasias. PMID: 23563356
    28. Our results suggest that in acute depression TPH1 A218C polymorphism and specifically the CC genotype together with the information on remission or treatment response differentiates between different temperament profiles and their changes. PMID: 23597148
    29. Associations between adolescents' physical activity and depressive symptoms are not modified by plasticity genes. PMID: 23088179
    30. This study detected allelic or genotypic associations of TPH1 in clinically significant depression in Alzheimer;s disease . PMID: 23157339
    31. There is a relationship between sex, age & the TPH1 locus, with a trend towards a lower frequency of the AA genotype in former smokers. The TPH1 polymorphism is an indicator of therapeutic failure in smoking cessation. PMID: 23177301
    32. The GGCCGGGC haplotype in the first haplotype block of TPH1 was significantly associated with middle insomnia. PMID: 22429480
    33. TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT is pivotal in AAI and lack of 5-HT leads to impaired Th2 priming capacity of bone marrow dendritic cells. PMID: 23328530
    34. The TPH1 A218C polymorphism is a potential biomarker for bipolar disorder and alcohol dependence risk in Caucasian population (Meta-Analtsis) PMID: 21601290
    35. variants in TPH1 gene constitute risk factors for post traumatic stress disorder symptoms. PMID: 22483952
    36. Among maltreated children, polymorphisms of TPH1 were related to heightened self-report and peer report of antisocial behavior. PMID: 22781862
    37. Aggression in MDD patients is more susceptible to an excess of TPH1 CC homozygote than in undifferentiated somatoform disorder patients. TPH1 gene is most likely to have a shared effect on aggression and MDD. PMID: 22697203
    38. Variation in TPH1 may increase risk for developing borderline personality disorder as a result of childhood abuse. PMID: 21989108
    39. In conclusion, regardless of visceral hypersensitivity state, several serotonergic signaling components are altered in IBS patients. PMID: 22323131
    40. results indicate that the TPH1 CC recessive genotype is likely to be a genetic risk factor for criminal behavior, especially homicidal behavior in patients with schizophrenia. PMID: 22053918
    41. In non-diabetic controls, SNPs of TPH1 were associated with waist circumference and BMI. PMID: 21836641
    42. we concluded that TRH1 SNP is not associated with either adolescent idiopathic scoliosis predisposition or curve severity in Japanese. PMID: 21308753
    43. Results describe associations of tryptophan hydroxylase 1 and 2 gene variants with irritable bowel syndrome-related GI symptoms and stool characteristics. PMID: 21073637
    44. This study indicated that the TPH1 218A/C genotype and allele frequencies differed between Taiwanese healthy controls and patients with major depressive disorder PMID: 20945066
    45. The results suggest that TPH1 gene variation participates in the regulation of serotonin and dopamine turnover rates in the central nervous system of healthy human subjects. PMID: 20580984
    46. tryptophan hydroxylase 1 (TPH1) has a role in schizophrenia susceptibility and suicidal behavior PMID: 19526457
    47. TPH1 variation (rs10488683) was relevant in the diathesis for suicide attempts. PMID: 19381154
    48. Family analysis of 38 TPH1 mutation carriers and 41 of their offspring revealed that offspring of mothers carrying TPH1 mutations reported 1.5- to 2.5-times-higher ADHD scores and related symptoms during childhood and as adults than did controls. PMID: 20921119
    49. In the single largest attention-deficit/hyperactivity disorder (ADHD) genetic study of TPH1 and TPH2 variants presented to date (n = 3,559 individuals), evidence for a substantial effect of common genetic variants on persistent ADHD, was not found. PMID: 20213726
    50. Polymorphism of the TPH gene-T457C locus could show ethnic and regional differences. PMID: 18402117

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  • 蛋白家族：
    Biopterin-dependent aromatic amino acid hydroxylase family
  • 組織特異性：
    [Isoform 2]: Seems to be less widely expressed than isoform 1.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12008

    OMIM: 191060

    KEGG: hsa:7166

    STRING: 9606.ENSP00000250018

    UniGene: Hs.591999