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  4. Recombinant Human Tyrosine-protein kinase SgK223 (SGK223), partial

Recombinant Human Tyrosine-protein kinase SgK223 (SGK223), partial

  • 中文名稱：
    人PRAG1重組蛋白
  • 貨號：
    CSB-YP801267HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PRAG1重組蛋白
  • 貨號：
    CSB-EP801267HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PRAG1重組蛋白
  • 貨號：
    CSB-EP801267HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PRAG1重組蛋白
  • 貨號：
    CSB-BP801267HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PRAG1重組蛋白
  • 貨號：
    CSB-MP801267HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PRAG1
  • Uniprot No.：
  • 別名：
    D8Ertd82e; DKFZp761P0423; DNA segment, Chr 8, ERATO Doi 82; EC 2.7.10.2; Homolog of rat pragma of Rnd2; LOC157285; PRAGMIN ; SG223_HUMAN; Sgk223; Sugen kinase 223; Tyrosine protein kinase SgK223; Tyrosine-protein kinase SgK223
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

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靶點詳情

  • 功能：
    Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling.
  • 基因功能參考文獻(xiàn)：
    1. analysis of how the kinase fold mediates non-catalytic functions in SgK223 PMID: 29079850
    2. deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis PMID: 27116701
    3. Results provide evidence that NACK was strongly expressed in a subset of non-small cell lung cancer (NSCLCL) samples and interference of NACK inhibits NSCLC progression through failing to activate Notch1 signaling complexes. PMID: 26782286
    4. Increased expression of SgK223 occurs in PDAC, and overexpression of SgK223 in pancreatic ductal epithelial cells promotes acquisition of a migratory and invasive phenotype through enhanced JAK1/Stat3 signaling PMID: 26215634
    5. Pragmin as a mammalian EPIYA effector and suggests that bacterial EPIYA effectors target Pragmin to subvert SFKs for successful infection. PMID: 21873224
    6. Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling PMID: 16481321
    7. Also known as SgK223, a member of the NKF3 subfamily of eukaryotic protein kinases. PMID: 12471243

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell junction, focal adhesion. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25438

    OMIM: 617344

    KEGG: hsa:157285

    STRING: 9606.ENSP00000330930

    UniGene: Hs.583863