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  4. Recombinant Human UPF0577 protein KIAA1324 (KIAA1324), partial

Recombinant Human UPF0577 protein KIAA1324 (KIAA1324), partial

  • 中文名稱：
    人KIAA1324重組蛋白
  • 貨號：
    CSB-YP764944HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KIAA1324重組蛋白
  • 貨號：
    CSB-EP764944HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KIAA1324重組蛋白
  • 貨號：
    CSB-EP764944HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KIAA1324重組蛋白
  • 貨號：
    CSB-BP764944HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KIAA1324重組蛋白
  • 貨號：
    CSB-MP764944HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KIAA1324
  • Uniprot No.：
  • 別名：
    EIG121; Estrogen induced gene 121; Estrogen-induced gene 121 protein; Hypothetical protein LOC57535; K1324_HUMAN; KIAA1324; MABA1; MGC150624; UPF0577 protein KIAA1324
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. May play a role in apoptosis and cell proliferation through its interaction with HSPA5.
  • 基因功能參考文獻(xiàn)：
    1. it was found that EIG121 exerted dual functions in the regulation of autophagy and stemness not only in normal JEC cells but also JEC obtained CSCs. These findings could be useful for developing targeted therapies for endometrial carcinoma PMID: 28656197
    2. The STR in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here PMID: 27230222
    3. A tumor suppressive role of KIAA1324 via inhibition of GRP78 oncoprotein activities in gastric cancer PMID: 26045166
    4. EIG121 may protect cells from cell death by upregulating the autophagy pathway. PMID: 21072319
    5. High expression of ERalpha and the estrogen-induced gene EIG121 predicts shorter overall survival in patients with high-grade serous ovarian carcinoma. PMID: 21102415
    6. Down-regulation of KIAA1324 protein is associated with endometrial cancer PMID: 16322283

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    UPF0577 family
  • 組織特異性：
    Expressed in normal endometrium but overexpressed in endometroid tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29618

    OMIM: 611298

    KEGG: hsa:57535

    UniGene: Hs.708190