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  4. Recombinant Human herpesvirus 1 Ribonucleoside-diphosphate reductase large subunit (UL39), partial

Recombinant Human herpesvirus 1 Ribonucleoside-diphosphate reductase large subunit (UL39), partial

  • 中文名稱：
    Recombinant Human herpesvirus 1 Ribonucleoside-diphosphate reductase large subunit (UL39) ,partial,Yeast
  • 貨號：
    CSB-YP020518HWY
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Ribonucleoside-diphosphate reductase large subunit (UL39) ,partial,Yeast
  • 貨號：
    CSB-EP020518HWY
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Ribonucleoside-diphosphate reductase large subunit (UL39) ,partial,Yeast
  • 貨號：
    CSB-EP020518HWY-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Ribonucleoside-diphosphate reductase large subunit (UL39) ,partial,Yeast
  • 貨號：
    CSB-BP020518HWY
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Ribonucleoside-diphosphate reductase large subunit (UL39) ,partial,Yeast
  • 貨號：
    CSB-MP020518HWY
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RIR1
  • Uniprot No.：
  • 別名：
    RIR1; UL39; Ribonucleoside-diphosphate reductase large subunit; R1; EC 1.17.4.1; Ribonucleotide reductase large subunit
  • 種屬：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ribonucleoside-diphosphate reductase holoenzyme that provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Prevents host necroptosis by targeting host RIPK1 and RIPK3, thereby hampering the formation of necroptotic RIPK1-RIPK3 complexes. Forms hetero-amyloid structures with host proteins RIPK3 or ZBP1 which may prevent RIPK3- and ZBP1-mediated necroptosis. In addition, inhibits extrinsic apoptosis by targeting host CASP8.
  • 基因功能參考文獻：
    1. determined that subtle alteration of the UL39 gene regulates expression and functions of ICP6 and severely impacts HSV-1 pathogenesis, potentially making KOS-NA a promising vaccine candidate against HSV-1. PMID: 29321311
    2. The ribonucleotide reductase large subunit R1 was sufficient to suppress TNF-induced necrosis, and its RIP homotypic interaction motif (RHIM) domain was required to disrupt the RIP1/RIP3 complex in human cells. PMID: 26559832
    3. Thus, by interacting with caspase 8 and RIP1, HSV R1s impair the apoptotic host defense mechanism prompted by dsRNA. PMID: 21697465
  • 蛋白家族：
    Ribonucleoside diphosphate reductase large chain family
  • 數(shù)據(jù)庫鏈接：

    KEGG: vg:2703361