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Recombinant Mouse Acetyl-CoA acetyltransferase, cytosolic (Acat2)

  • 中文名稱：
    Recombinant Mouse Acetyl-CoA acetyltransferase, cytosolic(Acat2),Yeast
  • 貨號(hào)：
    CSB-YP805555MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Acetyl-CoA acetyltransferase, cytosolic(Acat2),Yeast
  • 貨號(hào)：
    CSB-EP805555MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Acetyl-CoA acetyltransferase, cytosolic(Acat2),Yeast
  • 貨號(hào)：
    CSB-EP805555MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Acetyl-CoA acetyltransferase, cytosolic(Acat2),Yeast
  • 貨號(hào)：
    CSB-BP805555MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Acetyl-CoA acetyltransferase, cytosolic(Acat2),Yeast
  • 貨號(hào)：
    CSB-MP805555MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Acat2
  • Uniprot No.：
  • 別名：
    Acat2; Acetyl-CoA acetyltransferase; cytosolic; EC 2.3.1.9; Cytosolic acetoacetyl-CoA thiolase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-397
  • 氨基酸序列
    MNAGSDPVVI VSAARTAIGS FNGALSTVPV HEMGTTVIKE VLQRAKVAPE EVSEVIFGHV LTAGCGQNPT RQASVGAGIP YSVPAWSCQM ICGSGLKAVC LAAQSIAMGD STIVVAGGME NMSKAPHLTH LRTGVRMGEV PLADSILCDG LTDAFHNYHM GITAENVAKK WQVSREAQDK VAVLSQNRAE HAQKAGHFDK EIVPVLVSSR KGLTEVKIDE FPRHGSNLEA MGKLKPYFLT DGTGTVTPAN ASGMNDGAAA VVLMKKTEAE RRMLKPLARI VSWSQAGVEP SVMGVGPIPA IKQAVAKAGW SLEDVDLFEI NEAFAAVSAA IAKELGLNPE KVNIDGGAIA LGHPLGASGC RILVTLLHTL ERVGGTRGVA ALCIGGGMGV AMCVQRG
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the biosynthetic pathway of cholesterol.
  • 基因功能參考文獻(xiàn)：
    1. lipid-induced stabilization of ACAT2 ameliorates lipotoxicity from excessive cholesterol and fatty acid. This unconventional cysteine ubiquitylation of ACAT2 constitutes an important mechanism for sensing lipid-overload-induced ROS and fine-tuning lipid homeostasis. PMID: 28604676
    2. Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs PMID: 25030663
    3. ACAT2 seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL, the latter via up-regulation of ABCA1 PMID: 24695360
    4. handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency PMID: 22669916
    5. inhibition of intestinal or hepatic ACAT2 improves atherogenic hyperlipidemia and limits hepatic cholesteryl ester accumulation PMID: 22460046
    6. Pyripyropene ACAT2-selective inhibition in the intestine and the liver can be effective against atherosclerosis. PMID: 21393580
    7. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. PMID: 20231283
    8. ACAT2 provides core CE of newly secreted VLDL, whereas LCAT adds CE during LDL particle formation PMID: 15805543
    9. ABCA1, especially in the absence of ACAT2, can have a significant effect on cholesterol absorption, although ACAT2 has a more substantial role in this process than ABCA1 PMID: 16150828
    10. depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss PMID: 18281279

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  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Thiolase family
  • 數(shù)據(jù)庫鏈接：