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  4. Recombinant Mouse E3 ubiquitin-protein ligase pellino homolog 2 (Peli2)

Recombinant Mouse E3 ubiquitin-protein ligase pellino homolog 2 (Peli2)

  • 中文名稱：
    小鼠Peli2重組蛋白
  • 貨號(hào)：
    CSB-YP807400MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Peli2重組蛋白
  • 貨號(hào)：
    CSB-EP807400MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Peli2重組蛋白
  • 貨號(hào)：
    CSB-EP807400MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Peli2重組蛋白
  • 貨號(hào)：
    CSB-BP807400MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Peli2重組蛋白
  • 貨號(hào)：
    CSB-MP807400MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Peli2; E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; EC 2.3.2.27; RING-type E3 ubiquitin transferase pellino homolog 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-419
  • 氨基酸序列
    MFSPGQEEPS APNKEPVKYR ELVVLGYNGA LPNGDRGRRK SRFALYKRTY ASGVKPSTIH MVSTPQASKA ISSRGHHSIS YTLSRSQTVV VEYTHDKDTD MFQVGRSTES PIDFVVTDTV SGGQNEDAQI TQSTISRFAC RIVCDRNEPY TARIFAAGFD SSKNIFLGEK AAKWKNPDGH MDGLTTNGVL VMHPQGGFTE ESQPGVWREI SVCGDVYTLR ETRSAQQRGK LVESETNVLQ DGSLIDLCGA TLLWRTADGL FHAPTQKHIE ALRQEINAAR PQCPVGLNTL AFPSINRKEV VEEKQPWAYL SCGHVHGYHS WGHRSDTEAN ERECPMCRTV GPYVPLWLGC EAGFYVDAGP PTHAFTPCGH VCSEKSAKYW SQIPLPHGTH AFHAACPFCA TQLVGEQNCI KLIFQGPVD
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
  • 基因功能參考文獻(xiàn)：
    1. Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control. PMID: 22669975
    2. Pellino-2 is a tissue-restricted component of a signaling pathway that couples the mouse pelle-like kinase/IL-1 receptor-associated kinase protein to IL-1- or lipopolysaccharide-dependent signaling. PMID: 12370331
  • 蛋白家族：
    Pellino family
  • 組織特異性：
    Widely expressed both in embryos and adult. Weakly or not expressed in spleen and thymus.
  • 數(shù)據(jù)庫(kù)鏈接：