Recombinant Mouse Protein ALEX (Gnas)
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中文名稱:小鼠Gnas重組蛋白
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貨號:CSB-YP747529MO
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規(guī)格:
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來源:Yeast
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其他:
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中文名稱:小鼠Gnas重組蛋白
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貨號:CSB-EP747529MO
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規(guī)格:
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來源:E.coli
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其他:
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中文名稱:小鼠Gnas重組蛋白
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貨號:CSB-EP747529MO-B
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規(guī)格:
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來源:E.coli
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共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名稱:小鼠Gnas重組蛋白
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貨號:CSB-BP747529MO
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規(guī)格:
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來源:Baculovirus
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其他:
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中文名稱:小鼠Gnas重組蛋白
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貨號:CSB-MP747529MO
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規(guī)格:
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來源:Mammalian cell
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其他:
產(chǎn)品詳情
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純度:>85% (SDS-PAGE)
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基因名:
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Uniprot No.:
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別名:Gnas; Gnas1; Protein ALEX; Alternative gene product encoded by XL-exon
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種屬:Mus musculus (Mouse)
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蛋白長度:full length protein
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表達區(qū)域:1-725
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氨基酸序列MSPSPTRLAV RSVDPQKTPN LTSKAPARPS RKSEWVETTA HLRRKPCHSR HNSPAWEISG PPWSSQDHLG PHQASKPSTQ RFWSPGPPLA RAQAWEPIPP HQKKLCHLSS TSLPRETIAS LPCKSQTLRQ EVRKHWSPEL FPRSPGTSDL KTLASEKTTA LPLKNLCHFR SVEKNSGAIA HPQDSRESSH KSALAASSRQ SRSRVRSASL PPRTRLPSGS EAPLTDHSAR LSDLLLTSHA TAPRWRSPDP CLRLAEPPLG STTTPLSIWT APQSQVMARP SKSREPQIRA SAQRDPQLSE KQPRWKEALP PPLRWKEKSP LRREGTDLPP SLKQWMPSQP LLPKPSLPDL MLELLRIPRC SQIARAMPEK TGQPQERLQI SSRILKNSKK PQLSAPILTE GQPQSPQPLL PSPSLKAAEI QPPSQPPRQS LPPRPSLPPG QPLSPRWSPQ PRQSLPPWRS LPPGQPLSPP RSPLPGQSPL LEPIRPLEQS LAPQQCQPLL GQLPLGQPMQ VHWSGEPGHS QLLPPLGHPF LPAQQLPPGQ PLLPAQSLLA GQPLPPPAGP ILDPPAPRSR LLTRLLRGLL RGRLPGLTST SGAEAAAGTR HRLASARSSP PVMSRKKGPP AASSGFCGET AALACPGATR SGATQSATSS PEPSEAASVY PSVPDHDPSA PGRPRILWRR GANRCAKKPL RCESRSAQIR NAASSSTSNW RRRRWTTCVH TACCF
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蛋白標簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
靶點詳情
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功能:May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.
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基因功能參考文獻:
- In mice that express activated KRAS in the pancreas, we found expression of GNAS(R201C) to cause development of more differentiated tumors, with gene expression pattern associated with the ductal phenotype. PMID: 30142336
- Gsalpha regulates osteoclast differentiation and function through cAMP/PKA and Wnt/beta-catenin pathways. PMID: 28338087
- Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Galphas upon receptor activation PMID: 29079700
- This study demonstrates that induced expression of the fibrous dysplasia (FD) Galphas mutant from the mouse endogenous Gnas locus exhibits human FD phenotypes in vivo, and that inhibitors of Wnt/beta-catenin signaling may be repurposed for treating FD and other bone diseases caused by Galphas activation. PMID: 29158412
- high osteoblastic GalphaS expression results in aberrant skeletal development in which bone production is favored at the cost of bone quality. PMID: 28727179
- Our findings suggest that a cis-acting factor could be implicated in reducing paternal Galphas expression in brown adipose tissue PMID: 28694163
- Our data revealed a positive correlation between hepatic Gsalpha-cAMP signal axis and fasting blood glucose (FBG) in slight insulin resistance stage of HIgh Sugar High Fat-diet rats and diabetic db/db mice. The current finding thus suggested hepatic Gsalpha-cAMP signal axis plays a central role in regulating of FBG during the developing and development of T2DM. PMID: 28260721
- retrograde trafficking to the trans-Golgi network induces local Gs-protein activation and cAMP/PKA signaling at a critical position near the nucleus, which appears required for efficient CREB phosphorylation and gene transcription PMID: 28874659
- Gsalpha deficiency in JG cells of adult mice results in kidney injury, suggesting that JG cells are critically involved in the maintenance and protection of the renal microvascular endothelium. PMID: 28775003
- results show that most of the PatDp(dist2) phenotype is due to overexpression of Gnasxl combined with loss of expression of Gnas, and suggest that Gnasxl and Gnas may act antagonistically in a number of tissues and to cause a wide range of phenotypic effects PMID: 23822972
- results suggest that the T1R3 homomeric sweet taste receptor negatively regulates adipogenesis through Galphas-mediated microtubule disassembly and consequent activation of the Rho/ROCK pathway. PMID: 28472098
- results show that Gsalpha imprinting in the dorsomedial nucleus of the hypothalamus (DMH) underlies the parent-of-origin metabolic phenotype that results from Gsalpha mutations and that DMH MC4R/Gsalpha signaling is important for regulation of energy expenditure and brown adipose tissue activation, but not the metabolic response to cold. PMID: 27991864
- activating mutations in GNAS and Kras cooperatively promote murine pancreatic tumorigenesis PMID: 26257060
- Authors demonstrated that Nesp55 is co-localized with serotonin and then went on to show that in midbrain regions there were reductions in mRNA expression of the serotonin-specific genes Tph2 and Slc6a4, but not the dopamine-specific gene Th in Nesp(m/+) mice. PMID: 27509352
- Disruption of Gnas in smooth muscle of mice reduced intestinal motility and led to death within 4 weeks. GNAS disruption in adults impaired contraction of intestinal smooth muscle and peristalsis with features of intestinal pseudo-obstruction characterized by chronic intestinal dilation and dysmotility. PMID: 28043906
- Gsalpha signaling in adipose tissues may therefore affect whole-body glucose metabolism in the absence of an effect on body weight. PMID: 26712027
- Ventromedial hypothalamic Gsalpha/cyclic AMP signaling regulates glucose homeostasis and alters leptin sensitivity in mice, particularly in the setting of excess caloric intake. PMID: 26671183
- findings suggest that XLalphas enhances Gq/11 signaling to mediate the renal actions of PTH during early postnatal development. PMID: 26307011
- These data demonstrate that effects of Gsalpha mutations underpinning FD-defining tissue changes and morbidity do not reflect the effects of the mutations on osteoblasts proper. PMID: 25487351
- a novel role of Galphas in control of neural progenitor asymmetric cell division via suppressing Numb mediated Notch signaling inhibition PMID: 25916881
- This study highlights an important tumour suppressive function of Galphas-PKA, limiting the proliferation of epithelial stem cells and maintaining proper hair follicle homeostasis. PMID: 25961504
- Gsalpha mutations are sufficient to cause FD, and are per se compatible with germline transmission and normal embryonic development in mice. Our novel murine lines constitute the first model of FD. PMID: 24764158
- targeted ablation of Gs alpha in early osteoblast precursors, but not in differentiated osteocytes, results in a dramatic increase in bone marrow adipocytes. PMID: 24806274
- a paternally inherited Gnas cluster showing ectopic expression of Nesp is "maternalised" in terms of Gnasxl and Gnas expression. PMID: 25659103
- Altered gene dosages for Galphas and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost. PMID: 24550008
- study concludes that XLalphas is required for the inhibition of sympathetic outflow towards cardiovascular and metabolically relevant tissues PMID: 23748904
- Here we describe maternal inheritance of a new Gnas mutation, Ex1A-T, which gives rise to a small but highly significant overgrowth phenotype which we attribute to reduction of maternally expressed NESP55. PMID: 23839232
- In animal models, genetically-mediated ectopic Hedgehog signaling is sufficient to induce heterotopic ossification, whereas inhibition of this signaling pathway by genetic or pharmacological means strongly reduces the severity of this condition. PMID: 24076664
- The effects of Gnas dysregulation on osteoblast differentiation, were examined. PMID: 22903279
- Data indicate that mice lacking Gsalpha in osteocytes showed a dramatic increase in myeloid cells in bone marrow, spleen, and peripheral blood. PMID: 23160461
- Results indicate that although G(s)alpha deficiency in PVN partially contributes to the metabolic phenotype, G(s)alpha imprinting in other CNS regions is also important in mediating the CNS effects of G(s)alpha mutations. PMID: 22733970
- Supporting a role for Gnas in adipogenesis in vivo, fat tissue weight and expression of adipogenic genes from multiple types of adipose tissues from Gsalpha(+/p-) mice were significantly decreased. PMID: 22511293
- in mice with loss of imprinting of Gnas, NREM and complex cognitive processes are enhanced while REM and REM-linked behaviors are inhibited PMID: 22589743
- Umami taste receptor functions as an amino acid sensor via Galphas subunit in N1E-115 neuroblastoma cells. PMID: 22189795
- The neonatal phenotype of mutant mice appears to be due to a transient role of XLalphas in muscle tissues. PMID: 22253771
- Galphas and cAMP has a divergent requirement in the differentiation and inflammatory profile of distinct mouse Th subsets PMID: 22326954
- Findings indicate that stimulatory G-protein G(alphas)-wt transfected cells showed more sensitization of adenylyl cyclase (AC) and mu1-opioid receptor interacted with G(alphas) after chronic morphine exposure. PMID: 22177524
- XLalphas is involved in the regulation of bone and adipocyte metabolism PMID: 22215617
- GalphaS protein coupling to adenylate cyclase mediates membrane-tethered amyloid precursor protein intracellular domain-induced neurite outgrowth. PMID: 22302812
- Gnas is a key regulator of fate decisions in adipose-derived mesenchymal progenitor cells. PMID: 21812029
- Fast-to-slow-fiber-type switch in G(s)alpha deficiency at older ages is likely an adaptive response, allowing higher fatigue resistance in adaption to metabolic deficiency and aging. PMID: 21680879
- activated XLalphas and Galphas traffic differently, and this may form the basis for the differences in their cellular actions PMID: 21890629
- creatine loss ins a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha PMID: 19913550
- Gnas gene exhibits a complex imprinted pattern, giving rise to transcripts that are maternally, paternally, or biallelically expressed. PMID: 10097123
- long-term effect on renal function, blood pressure, and renal pathology in Gsapha deletion low renin and diuretic mouse model PMID: 20551626
- G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. PMID: 20374964
- THe Nesp55 differentially methylated region is an additional principal imprinting control region, which directs Gnas methylation and thereby affects expression of all maternal Gnas-derived transcripts. PMID: 20427744
- Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling PMID: 20133939
- XLalpha(s) is capable of functionally coupling to receptors that normally act via Gs(alpha). PMID: 12145344
- results indicate that Gs activity in the oocyte is required to maintain meiotic arrest within the ovarian follicle and suggests that the follicle may keep the cell cycle arrested by activating Gs PMID: 12193786
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亞細胞定位:Cell membrane; Peripheral membrane protein. Cell projection, ruffle.
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蛋白家族:ALEX family
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數(shù)據(jù)庫鏈接:
UniGene: Mm.125770
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