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  4. Recombinant Mouse Toll-like receptor 11 (Tlr11), partial

Recombinant Mouse Toll-like receptor 11 (Tlr11), partial

In Stock
  • 中文名稱(chēng)：
    小鼠Tlr11重組蛋白
  • 貨號(hào)：
    CSB-EP764846MO
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Tlr11
  • Uniprot No.：
  • 別名：
    Toll-like receptor 12
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 來(lái)源：
    E.coli
  • 分子量：
    25.7 kDa
  • 表達(dá)區(qū)域：
    769-926aa
  • 氨基酸序列
    RGQFNYDVFISYCEEDQAWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGNDRMESMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGTTHLLLLFLEPLDRQRLHSYHRLSRWLQKEDYFDLSQGKVEWNSFCEQLKRRLSKAGQERD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 基因功能參考文獻(xiàn)：
    1. mechanisms of interaction with flagellin and profilin PMID: 26859749
    2. Data show that TLR11 expression is induced in astrocytes, neurons, and microglia in the immune response to T. gondii infection PMID: 24704432
    3. TLR11 mediates innate immune function of male germ cells in response to T. gondii profilin and uropathogenic escherichia coli stimulations. PMID: 24403550
    4. Biochemical experiments revealed that TLR11 and TLR12 directly bind to Toxoplasma gondii profilin and are capable of forming a heterodimer complex. PMID: 24078692
    5. Selective elimination of neutrophils in TLR11-deficient mice infected with Toxoplasma gondii results in acute susceptibility similar to that observed in IFN-gamma-deficient mice. PMID: 23754402
    6. a potentially important role for TLR11 in preventing murine intestinal infection and modulating antigen transportation in the gut and imply an important role for various TLRs in cooperation with tight control of pathogens penetrating into Peyer patches. PMID: 23135279
    7. association with UNC93B1 and the intracellular localization of TLRs are not unique features of nucleic acid-sensing TLRs but is also essential for TLR11-dependent recognition of T. gondii profilin and for host protection against this parasite PMID: 21097503
    8. Data demonstrate that transcription of the Tlr11 gene is regulated through epithelium-specific transcription factors and IRF-8. PMID: 19801549
    9. displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells; mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria PMID: 15001781
    10. Toxoplasma gondii profilin activates dendritic cells through TLR11 and is the first chemically defined ligand for this TLR; TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection PMID: 15860593
    11. The immunogenicity of Toxoplasma gondii profilin was entirely dependent on both TLR11 recognition and signaling through the adaptor myeloid differentiation factor 88 (MyD88). PMID: 17000122
    12. TLR11-deficient mice develop an abnormal immunopathological response to Toxoplasma gondii, as the result of non-toll-like receptor dependent activation of interferon-gamma secretion by natural killer cells in response to the infection. PMID: 19050265
    13. TLRs 11-13 are expressed in normal and parasite infected mouse brains. This suggests a role for them in central nervous system infections. PMID: 19077284

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Toll-like receptor family
  • 數(shù)據(jù)庫(kù)鏈接：