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  4. Recombinant Mouse Transcription factor Spi-C (Spic)

Recombinant Mouse Transcription factor Spi-C (Spic)

  • 中文名稱：
    小鼠Spic重組蛋白
  • 貨號(hào)：
    CSB-YP750795MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Spic重組蛋白
  • 貨號(hào)：
    CSB-EP750795MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Spic重組蛋白
  • 貨號(hào)：
    CSB-EP750795MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Spic重組蛋白
  • 貨號(hào)：
    CSB-BP750795MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Spic重組蛋白
  • 貨號(hào)：
    CSB-MP750795MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Spic
  • Uniprot No.：
  • 別名：
    Spic; Transcription factor Spi-C; Pu.1-related factor; Prf
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-242
  • 氨基酸序列
    MTCCIDQDSL GQTFQDAIDI LIQQSAGESQ YSSENRNYMA IINPYPHVRG NANYYGMSPT ENPLYDWRGV TNGSADLYLE GGFHQSVQNI AESQLVQPPF FQQKGGRGRR KLRLFEYLFE SLCNSEMVSC IQWVDKARGI FQFISKNKET LAELWGQRKG NRKPMTYQKM ARALRNYART GEIIKIRRKL TYQFSEAVLQ RLAPANYLGK DLFYPQYGQP DQGYLSLNHW NANHYAHGSY QS
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
  • 基因功能參考文獻(xiàn)：
    1. These results indicate a novel role for Spi-C as a negative regulator of B cell development and function. PMID: 25769919
    2. Study reports that Spic regulated the development of F4/80(+)VCAM1(+) bone marrow macrophages (BMM) and that Spic expression in BMM and red pulp macrophages development was induced by heme, a metabolite of erythrocyte degradation. PMID: 24630724
    3. The Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice. PMID: 16338660
    4. Spi-C has the potential to modulate PU.1 activity to promote B cell differentiation. PMID: 16887979
    5. data indicate that ectopic expression of Spi-C can impair B-cell development and function by affecting genes associated with BCR signaling PMID: 18792411
    6. Spi-C controls development of red pulp macrophages required for red blood cell recycling and iron homeostasis PMID: 19037245

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 組織特異性：
    Expressed in lymphoid tissues, including spleen, bone marrow and thymus. According to PubMed:19037245, highly expressed in red pulp macrophages and, at lower, levels in B-cells, but not in other cells, including, monocytes, dendritic cells and other tissu
  • 數(shù)據(jù)庫(kù)鏈接：