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  4. Recombinant Mouse Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial

Recombinant Mouse Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial

  • 中文名稱：
    小鼠Trpv1重組蛋白
  • 貨號：
    CSB-YP747826MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Trpv1重組蛋白
  • 貨號：
    CSB-EP747826MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Trpv1重組蛋白
  • 貨號：
    CSB-EP747826MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Trpv1重組蛋白
  • 貨號：
    CSB-BP747826MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Trpv1重組蛋白
  • 貨號：
    CSB-MP747826MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Trpv1; Transient receptor potential cation channel subfamily V member 1; TrpV1; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
  • 基因功能參考文獻(xiàn)：
    1. analysis of the temporal mechanism for capsaicin activation of transient receptor potential vanilloid 1 ion channel PMID: 30038260
    2. injury-related TRPV1 signal is involved in healing of stromal incision injury in a mouse cornea by selectively stimulating TGFbeta-induced granulation tissue formation. PMID: 29971480
    3. TRPV1 SUMOylation is essential for the development of inflammatory thermal hyperalgesia PMID: 29670121
    4. Findings indicate brain TRPV cation channel (TRPV1) as potential detector of harmful stimuli and a key player of microglia to neuron communication. PMID: 28489079
    5. TRPV1 plays an important role in MAP reward. PMID: 29343767
    6. Bladder afferent responses to P2X receptor activation were depressed in TRPV1-/- mice. PMID: 29317663
    7. TRPV1 deletion impairs fracture healing, and inhibited osteoclastogenesis and osteogenesis. PMID: 28225019
    8. the pain and histamine-dependent itch sensations in mice are impaired due to a decreased phosphorylation level and reduced membrane localization of TRPV1. PMID: 29424270
    9. these data revealed a target-related (i.e. capsaicin-evoked) phenotype of TRPV1 Leu206Stop mice closely resembling that of published TRPV1 knockout mice. PMID: 29660342
    10. CuS-TRPV1 may represent a therapeutic tool to locally and temporally attenuate atherosclerosis PMID: 29335450
    11. Disruption of the association of Sig-1R with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein and to decreased levels of the ion channel protein as well as to a decrease in TRPV1-associated pain. PMID: 29378958
    12. Trpv1 gene deletion results in excessive inflammation, exaggerates cardiac hypertrophy. PMID: 29334670
    13. findings indicate that the initiation of the acute heat-evoked pain response in sensory nerve endings relies on three functionally redundant TRP channels, representing a fault-tolerant mechanism to avoid burn injury PMID: 29539642
    14. QLQX may improve diabetic cardiac function by regulating AGTR1/ TRPV1-mediated autophagy in STZ-induced diabetic mice. PMID: 29929188
    15. TRPV1 increased in the dorsal root ganglion (DRG) and spinal cord (SC) at 3 weeks after CFA injection. The expression levels of downstream molecules such as pPKA, pPI3K, and pPKC increased, as did those of pERK, pp38, and pJNK. Transcription factors (pCREB and pNFkappaB) and nociceptive ion channels (Nav1.7 and Nav1.8) were involved in this process. PMID: 29379798
    16. Mitochondrial modulation by all agents selectively increased cytosolic calcium in a subset of TRPA1/TRPV1-expressing (A1/V1+) neurons. There was a significant correlation between antimycin A-induced calcium responses and mitochondrial superoxide in wild-type 'responding' A1/V1+ neurons, which was eliminated in TRPA1-/- neurons, but not TRPV1-/- neurons PMID: 29734380
    17. TRPV1 serves a protective role against myocardial apoptosis during ischemia/reperfusion via the PI3K/Akt signaling pathway. PMID: 29286076
    18. We conclude that one of the possible regulatory mechanisms of TNF in mechanical orofacial hyperalgesia involves upregulation of the nociceptor TRPV1 PMID: 29132095
    19. Data (including data from studies in mutant mice and knockout mice) suggest that dietary basic amino acids L-ornithine and L-lysine stimulate gastrointestinal motility via activation of Trpv1 in small intestine; dietary L-arginine suppresses gastrointestinal motility. PMID: 28722259
    20. TRPV1 activation on sensory neurons (SN) innervating bone by the acidic cancer microenvironment in bone contributes to SN activation and bone pain. PMID: 28516219
    21. TRPV1 differentially contributes to spontaneous and bite-evoked pain during masseter inflammation, but both types of muscle pain are mediated by TRPV1-expressing nociceptors as well as NK1-expressing second-order neurons. PMID: 28669862
    22. High TRPV1 expression is associated with maternal fever-associated birth defects. PMID: 29018170
    23. These results suggest that neuronal TRPV1 signaling in periodontal tissue is crucial for the regulation of osteoclastogenesis via the neuropeptide CGRP. PMID: 27388773
    24. RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose. PMID: 29474476
    25. data demonstrate that lactate at physiologically relevant concentrations is a potent endogenous inhibitor of TRPV1. PMID: 27827430
    26. Data suggest that cold stress can induce brain injury, possibly through TRPV1 activation and the PI3K/Akt signaling pathway. PMID: 28669718
    27. Both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of allergic contact dermatitis. PMID: 29081531
    28. Both TRPV1 and GRP are part of a new mesoaccumbal glutamatergic pathway. PMID: 27762319
    29. Activation of TRPV1 might accelerate the development of the PAR2-triggered referred hyperalgesia in mice. PMID: 29289470
    30. These results indicate that TRPV1 is important for activating proinflammatory STAT3 signaling and thermoregulation-associated brain pathways in the brain. PMID: 27188969
    31. Dual FAAH and TRPV1 blockage inhibits contextual fear memory. PMID: 28583049
    32. TRPA1, TRPV1 and mast cells play an indispensable role in the development of toluene-2,4-diisocyanate-elicited airway hyperreactivity PMID: 27126687
    33. This study demonstrated that botulinum neurotoxin A doenregulation of Trpv1 in the dorsal root ganglia in mice PMID: 28410268
    34. that the augmented expression of TRPV1 in alpha-GalA(-/0) nociceptors may underly at least in part their increased heat sensitivity PMID: 27531673
    35. This study showed that spontaneous pain is dependent on the virulence determinant agr and bacterial pore-forming toxins (PFTs). The cation channel, TRPV1, mediated heat hyperalgesia as a distinct pain modality. PMID: 29295977
    36. Study suggests that deletion of TRPV1 receptors prevents reduction of hyperthermic seizure susceptibility in older mouse pups via a mechanism independent of hyperthermia-induced respiratory alkalosis, but possibly involves impaired development of thermoregulatory mechanisms, although at present, the mechanisms remain unknown. PMID: 27810513
    37. 4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling. PMID: 27682362
    38. Depending on the concentration, lidocaine employs TRPV1, TRPA1 and intracellular Ca2+ stores to induce a Ca2+-dependent release of the neuropeptide CGRP. Lidocaine-evoked cell death does not seem to require Ca2+ influx through TRPV1 or TRPV1 PMID: 29141003
    39. However, the mechanism that induces release of IL-6 from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway. PMID: 27979980
    40. Blockade of TRPV1, through genetic deletion or systemic or intra-nucleus accumbens (NAc) pharmacological means, inhibited morphine-induced CPP in mice. In addition, p38 MAPK inhibition blocked development of morphine conditioned place preference (CPP) as well. Moreover, blockade of either NAc p38 MAPK or TRPV1 dampened protein expression levels of p-p38 MAPK, AC1, and p-NF-kappaB which are normally induced by morphine ... PMID: 28734766
    41. Results suggest the involvement of TRPV1 in allergic asthma. PMID: 27255083
    42. Sensitization was relieved by pharmacological block of TRPV1 afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 channel activity. This neuronal-activity-induced USP5 upregulation may underlie a protective, transient sensitization of the pain pathway. PMID: 27974205
    43. antiobesity effect of KetoA was caused by TRPV1 activation-mediated browning in WAT. KetoA produced in the gut could therefore be involved in the regulation of host energy metabolism. PMID: 28754711
    44. studies identified TRPV4 as a channel that contributes to both histamine- and chloroquine-induced itch and indicated that the function of TRPV4 in itch signaling involves TRPV1-mediated facilitation. PMID: 27436359
    45. These findings indicate the EPO-induced Ca(2+) influx via the activation of the PLC-gamma1 signalling pathway, which leads to TRPV1 activation and consequently increases...angiogenesis. PMID: 27232578
    46. The activation of TRPV1 channels by dietary capsaicin triggers browning of white adipose tissue to counteract obesity. The results suggest that activation of TRPV1 channels is a promising strategy to counter obesity. PMID: 27174467
    47. study demonstrates that the anti-inflammatory effects of N-Arachidonoyl dopamine are mediated by TRPV1 expressed by nonhematopoietic cells and provide data suggesting that neuronal TRPV1 may mediate NADA's anti-inflammatory effects PMID: 28701511
    48. These findings demonstrate functional expression and the precise ultrastructural localization of TRPA1 and TRPV1 ion channels in freshly isolated mouse CMs. Crosstalk between TRPA1 and TRPV1 may be important in mediating cellular signaling events in cardiac muscle PMID: 27144598
    49. TRPA1 and TRPV1 appear to contribute to the propofol-mediated antagonism of U46619-induced constriction in murine coronary microvessels that involves activation of NOS and BKCa. PMID: 28644897
    50. Study showed that activation of TRPV1 and blockade of NMDA receptors produced antidepressant-like effects in male mice following amphetamine withdrawal, and these receptors are involved in amphetamine withdrawal-induced depressive-like behaviors; rapid antidepressant-like effects of capsaicin in forced swimming test and splash test are partly mediated by NMDA receptors PMID: 27167081

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  • 亞細(xì)胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV1 sub-subfamily
  • 組織特異性：
    Detected in neurons in the root ganglia (at protein level). Detected in dorsal root ganglia.
  • 數(shù)據(jù)庫鏈接：