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Recombinant Mouse Ubiquilin-2 (Ubqln2)

  • 中文名稱：
    小鼠Ubqln2重組蛋白
  • 貨號：
    CSB-YP889906MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ubqln2重組蛋白
  • 貨號：
    CSB-EP889906MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ubqln2重組蛋白
  • 貨號：
    CSB-EP889906MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ubqln2重組蛋白
  • 貨號：
    CSB-BP889906MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ubqln2重組蛋白
  • 貨號：
    CSB-MP889906MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ubqln2; Plic2Ubiquilin-2; Chap1; DSK2 homolog; Protein linking IAP with cytoskeleton 2; PLIC-2; Ubiquitin-like product Chap1/Dsk2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    2-638
  • 氨基酸序列
    AENGESSGP PRPSRGPAAA PGAASPPAEP KIIKVTVKTP KEKEEFAVPE NSTVQQFKEA ISKRFKSQTD QLVLIFAGKI LKDQDTLMQH GIHDGLTVHL VIKSQNRPQG QATTQPSTTA GTSTTTTTTT TAAAPAATTS SAPRSSSTPT TTNSSSFGLG SLSSLSNLGL NSPNFTELQN QMQQQLLASP EMMIQIMENP FVQSMLSNPD LMRQLIMANP QMQQLIQRNP EISHLLNNPD IMRQTLEIAR NPAMMQEMMR NQDLALSNLE SIPGGYNALR RMYTDIQEPM LNAAQEQFGG NPFATVGSSS TSGEGTQPSR TENRDPLPNP WAPPPTTQTA ATTTTTTTTS SGSGSGSSSS STTAGNTMAA ANYVASIFST PGMQSLLQQI TENPQLIQNM LSAPYMRSMM QSLSQNPDMA AQMMLSSPLF TSNPQLQEQM RPQLPNFLQQ MQNPETIAAM SNPRAMQALM QIQQGLQTLA TEAPGLIPSF APGVGMGVLG TAITPVGPVT PIGPIGPIVP FTPIGPIGPI GPTGPASSPG STGTGIPPAT TVSSSAPTET ISPTSESGPN QQFIQQMVQA LTGGSPPQPP NPEVRFQQQL EQLNAMGFLN REANLQALIA TGGDINAAIE RLLGSQPS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs). Links CD47 to vimentin-containing intermediate filaments of the cytoskeleton.
  • 基因功能參考文獻：
    1. Results have shown that the two P497S and P506T mutant UBQLN2 Tg mouse lines recapitulate the central features of ALS with frontotemporal dementia (ALS-FTD) found in humans and indicate that these mutant UBQLN2 mice with end stage of disease display a reduction of TDP-43 staining in the nucleus with concomitant formation of cytoplasmic ubiquitin+ inclusions in spinal motor neurons. PMID: 27834214
    2. UBQLN2 most evidently bound to HSP70-type chaperones, UBQLN1 and UBQLN4 and to a lesser extent to proteasomal subunits; UBQLN2 may be involved in the regulation of misfolded proteins. Mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice. PMID: 27477512
    3. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia type 3 PMID: 26141599
    4. UBQLN2 dysregulation in neurons can drive NF-kappaB activation and cytosolic TDP-43 aggregation. PMID: 26521126
    5. Transduction of UBQLN2 mutants (P497H, P497S, and P506T) induce proteinopathy and cause behavioral deficits, supporting a "toxic" gain-of-function amyotrophic lateral sclerosis model, in mice. PMID: 26152284
    6. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions PMID: 23774650
    7. UBQLN2-transfected cells did not show increased starvation-induced cell death. PMID: 19148225

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Membrane. Cytoplasmic vesicle, autophagosome.
  • 組織特異性：
    Highly expressed in smooth muscle. Expression in other tissues is very low.
  • 數(shù)據(jù)庫鏈接：