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  4. Recombinant Rat Progesterone receptor (Pgr), partial

Recombinant Rat Progesterone receptor (Pgr), partial

  • 中文名稱：
    大鼠Pgr重組蛋白
  • 貨號(hào)：
    CSB-YP017875RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pgr重組蛋白
  • 貨號(hào)：
    CSB-EP017875RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pgr重組蛋白
  • 貨號(hào)：
    CSB-EP017875RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pgr重組蛋白
  • 貨號(hào)：
    CSB-BP017875RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pgr重組蛋白
  • 貨號(hào)：
    CSB-MP017875RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pgr; Nr3c3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.; Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.; Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
  • 基因功能參考文獻(xiàn)：
    1. interactions between cells may facilitate the loss of progesterone receptor-mediated actions as part of a final common mechanism that remodels the cervix in certain etiologies of preterm and with parturition at term PMID: 24339918
    2. progestin-induced proliferation of endometrial stromal cells is mediated by ERK1-2 and AKT dependent early regulation of USF1, which directly induces Cdc2 PMID: 24859236
    3. membrane-initiated estradiol stimulation is able to induce and to potentiate the genomic activation of PR expression in the ventromedial nucleus PMID: 23817898
    4. there is a switch of progesterone receptor isoforms expression during the evening of proestrus that is related to the differential gene methylation patterns of their promoter regions, mainly for the isoform B promoter. PMID: 23994211
    5. The present study investigated the protective role of progesterone against ischemia-reperfusion-induced acute kidney injury (AKI) and possible involvement of progesterone receptors in ascorbic acid-mediated renoprotection in rats. PMID: 24246438
    6. Progesterone receptors mediate progesterone's ability to reduce the negative sexual behavioral effects of a mild stressor. PMID: 23153933
    7. The expression of ER and PR mRNAs in ectopic endometrium was significantly lower than that in eutopic and normal endometrium. PMID: 21166214
    8. PR activity is a critical factor ensuring proper carotid body function in newborn rats. PMID: 22326965
    9. Extra-nuclear activation of progesterone receptor has a role in regulating arterial smooth muscle cell migration PMID: 21440892
    10. The effects of progesterone and estradiol onpgrmc1 and pgr expression in hippocampal neurons are reported. PMID: 22147012
    11. Data demonstrate that, in vitro and in vivo, transthyretin is up-regulated by progesterone, and suggest that this response is mediated through a progesterone receptor-mediated mechanism. PMID: 20535645
    12. CDB-4124 has an effect on progesterone and estrogen receptors, and may suppress the development of precancerous lesions PMID: 21119048
    13. Developmental and hormone-induced epigenetic changes in PR genes in brain. PMID: 20702577
    14. the ability of estrogen to induce progesterone receptor immunoreactivity in the hypothalamus in ovariectomized rats is attenuated in old rats compared with young rats PMID: 20555290
    15. Results identify novel, early gene targets of the nuclear progesterone receptor that may be involved in the control of apoptosis and other biologically significant functions in periovulatory granulosa cells. PMID: 19818377
    16. progesterone isoforms are differentially expressed throughout proestrus-estrus transition and that mating modifies PR isoforms expression in the hypothalamus of the rat PMID: 20375746
    17. Upregulation of PR expression in the MPA during pregnancy and parturition may relate to the onset of maternal behavior and/or regulation of GnRH neuronal activity. PMID: 11814428
    18. the expression of PR in the medial preoptic nucleus suggest that PR may influence the sexual differentiation of the medial preoptic nucleus volume. PMID: 11920725
    19. estrogen receptor alpha and PR have different patterns of expression with differential responses to signals that modulate proliferation and/or apoptosis in rat uterine cervix PMID: 12193379
    20. demonstrate cell-specific Pgr localization and region-specific effect of estrogens on Pgr in the developing rat Mullerian duct PMID: 12354672
    21. differences in steroid secretion by the neonatal male and female gonads are responsible for producing sex differences in the level of progesterone receptor expression in the postnatal medial preoptic nucleus. PMID: 12372000
    22. Sex differences in the regulation of progesterone receptor isoform expression by sex steroid hormones in the rat brain suggests a contribution to the sexually dimorphic effects of progesterone in the rat brain. PMID: 12379440
    23. A diminished level of estrogen-induced progesterone receptor expression in the hypothalamus prevents progesterone from stimulating LH regulating circuits. PMID: 12419537
    24. The progesterone receptor plays a role in restraining GAD expression in the hypothalamus during proestrus, and this effect may be important for the production of the GnRH and LH surge. (progesterone receptor) PMID: 12457039
    25. an examination of its mRNA distribution in the brain stem PMID: 12638125
    26. An interaction of protein kinase C signaling pathway with estrogen-dependent progesterone receptor in ligand-independent activation manner in gonadotrope. PMID: 12952366
    27. Alkylphenol endocrine disrupters alter the neocortical function by affecting the progesterone receptor (PR) system, although the physiological significance of PR in the affected area is unknown. PMID: 14763995
    28. results suggest that progesterone receptor degradation by the 26S proteasome participates in the expression of progesterone-induced sequential inhibition in female rats PMID: 14764628
    29. Progesterone alters mesolimbic and nigrostriatal dopamine release but data suggest that it does not do so via nuclear progestin receptor in dopaminergic cells of the ventral tegmental area and substantia nigra. PMID: 15189328
    30. Proliferative response of uterine stromal cells to progestins PMID: 16020483
    31. Our results suggest that activation of progesterone receptors may be a mechanism by which cocaine mediates behavior through molecular alterations in the central nervous system. PMID: 17109827
    32. PRA+PRB+ mammary gland cells appear to be cell cycle arrested and do not proliferate. PMID: 17332059
    33. Results indicate that PR expression in the developing brain is extensive but transient: present in numerous forebrain nuclei but expression was absent in most nuclei by P28. PMID: 17614295
    34. A low percentage of tuberoinfundibular dopaminergic neurons expressed progesterone receptors throughout diestrus, pregnancy, and lactation. PMID: 17850461
    35. Steroid receptor mRNA levels in brown adipose tissue in male and female rats and in pregnant and lactating females, was analyzed. PMID: 17982270
    36. Variations in ERalpha and PR expression may promote changes in the activity of medial basal hypothalamus and preoptic area dopaminergic neurones. PMID: 18081559
    37. Endogenous oestradiol regulates progesterone receptor expression in the brain of female rat fetuses. PMID: 18208546
    38. Progesterone receptor expression is highly dependent on estradiol in the medial preoptic nucleus and the ventromedial nucleus of the adult rat brain. PMID: 18308846
    39. under the influence of hFSH, the ovaries produce a non-steroidal factor which suppresses all PR-dependent events of the LH surge elicited by estrogen PMID: 18310454
    40. A concurrent, indispensable role of ERalpha and PR in the generation of FSH surges and the stimulation of FSH responses to kisspeptin at the ovulatory period. PMID: 18635654
    41. Data show that progesterone receptor is transiently expressed within the first 2 weeks of life in specific motor, sensory and reticular core nuclei as well as within midbrain dopaminergic cell groups. PMID: 18712784
    42. Data suggest that some of progesterone's actions in the hippocampal formation may be mediated by direct and rapid actions on extranuclear progestin receptors and that PRs are well positioned to regulate progesterone-induced changes at synapses. PMID: 18720413
    43. The anxiolytic-like effects of progesterone in male rats can be mediated, in part, by progestin receptors, as these effects are blocked by prior treatment with a progestin receptor antagonist. PMID: 18958180
    44. These results suggest that the progesterone receptor B isoform is essential for the display of the lordosis behavior in rats. PMID: 19506349
    45. Letrozole-induced polycystic ovaries showed decreased progesterone receptor expression. PMID: 19698287

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 組織特異性：
    Isoform A and isoform B are expressed in the pituitary.
  • 數(shù)據(jù)庫鏈接：