The tag type will be
determined during production process. If you have specified tag
type, please tell us and we will develop the specified tag
preferentially.
產(chǎn)品提供形式:
Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶:
We recommend that this vial be briefly centrifuged prior
to opening to bring the contents to the bottom. Please reconstitute
protein in deionized sterile water to a concentration of 0.1-1.0
mg/mL.We recommend to add 5-50% of glycerol (final concentration) and
aliquot for long-term storage at -20℃/-80℃. Our default final
concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件:
Store at -20°C/-80°C upon receipt, aliquoting is necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期:
The shelf life is related to many factors, storage state,
buffer ingredients, storage temperature and the stability of the protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期:
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our
proteins are default shipped with normal blue ice packs, if you
request to ship with dry ice, please communicate with us in advance
and extra fees will be charged.
注意事項(xiàng):
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
基因功能參考文獻(xiàn):
WISP1 may be a potential inducer of airway smooth muscle proliferation and hypertrophy in asthma. The pro-remodeling effect of WISP1 is likely due to be involved in PI3K-GSK3beta-dependent noncanonical TGF-beta signaling. PMID: 26242865
Thymosin beta4 targets Wnt/WISP-1 signaling to protect against Ang II-induced cardiomyocyte growth. PMID: 26627308
initiate and perpetuate the pathological remodeling of asthma by inducing fibroblast proliferation and ECM deposition PMID: 23845395
these results showed the upregulation of WISP-1 in both in vitro and in vivo liver fibrosis models, and WISP-1 stimulated the proliferation of HSCs in vitro. PMID: 24600972
Results suggest that CCN4 is involved in the migration and proliferation of vascular smooth muscle cells. Inhibition of CCN4 may provide a promising strategy for the prevention of restenosis after vascular interventions. PMID: 23807044
WISP1/CCN4 autoregulates its expression through the promotion of beta-catenin activity and may employ beta-catenin to have a limited control over autophagy. PMID: 22475393
we demonstrate that WISP1 is present in primary hippocampal neurons during oxidant stress PMID: 22272766
Ang-II induced cardiomyocyte hypertrophy is mediated through AT1, NOX2 and the induction of WISP1, and may involve the direct interaction of AT1 with NOX2. PMID: 21376054
WISP-1 stimulates cardiomyocyte hypertrophy, fibroblast proliferation, and ECM expression in vitro. These results suggest that WISP-1 may play a critical role in post-myocardial infarction remodeling. PMID: 17616748