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Recombinant Mouse Aquaporin-3 (Aqp3)

  • 中文名稱：
    Recombinant Mouse Aquaporin-3(Aqp3)
  • 貨號：
    CSB-CF823166MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Aqp3
  • Uniprot No.：
  • 別名：
    Aqp3; Aquaporin-3; AQP-3; Aquaglyceroporin-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-292
  • 氨基酸序列
    MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYALAQTLGAFLGAGIVFGLYYDAIWAFANNELFVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGRHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSTEEENVKLAHMKHKEQI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
  • 基因功能參考文獻(xiàn)：
    1. results support a novel role for AQP3 in modulating renal injury and suggest the mechanisms involved in protection against hypoxic injury. PMID: 28344130
    2. The results of this study suggest that NAR relieves Lop-induced constipation by increasing the levels of interstitial cells of Cajal markers (c-Kit and SCF), as well as AQP3. Thus, NAR may be effective as a candidate in patients suffering from lifestyle-induced constipation. PMID: 29207043
    3. Increased expression of AQP3 and AQP10 in murine skin with the concomitant presence of an inflammatory stimulus (IMQ) and contact with detergent-containing water increases skin acanthosis and affects the biology of keratinocytes. PMID: 28111811
    4. AQP3(-/-) mice showed impaired healing of superficial wounds in the colon and impaired mucosal innate immune responses against Citrobacter rodentium infection. PMID: 28049834
    5. These results imply a critical role of AQP3 in asthma. PMID: 27165276
    6. This study found that both the airway epithelial cells of AQP3-knockout mice and AQP3-knockdown HBECs exhibited an obviously impaired self-healing capacity with defective epithelial cell migration through AQP3-facilitated glycerol transport. PMID: 27524635
    7. Decreased glycerol efflux from the skeletal muscles in AQP3 knockout mice may result in low exercise capacity. PMID: 27138166
    8. treatment of human HepG2 cells with TCDD also increased the expression of AQP3 mRNA and protein PMID: 26454884
    9. AQP3-facilitated H2O2 transport is required for NF-kappaB activation in keratinocytes in the development of psoriasis. PMID: 26100668
    10. Studied the effect of the total tannins extract of rhubarb on expression od aquaporin 2 and auqaporin 3 in diarrhoea mice. PMID: 25215286
    11. AQP3 has a pro-differentiative role in epidermal keratinocytes and PLD2 activity is necessary for this effect. PMID: 25233074
    12. analysis of the molecular link between the circadian clock and AQP3 function in mouse dorsal skin and HaCaT cells PMID: 24418925
    13. In a mouse model of intestinal ischemia the level of miR-874 expression was inversely related to AQP3 protein expression. PMID: 24462679
    14. Data indicate selective expression of aquaporins 3 and 8 in primitive erythroblasts and aquaporins 1 and 9 in adult definitive erythroblasts. PMID: 23243273
    15. We therefore suggest that AQP3-mediated H(2)O(2) uptake is required for chemokine-dependent T cell migration in sufficient immune response. PMID: 22927550
    16. It was concluded that acyl-CoA binding protein via aquaporin 3 is necessary for intact urine concentrating ability through efflux over the basolateral membrane of the collecting duct. PMID: 22237802
    17. The results of this study suggest that Gypsum fibrosum plays an important role in the increased levels of cutaneous AQP3 expression enhanced by Byakkokaninjinto. PMID: 22138657
    18. AQP3 as a novel determinant in macrophage immune function by a cellular mechanism involving facilitated water and glycerol transport, and consequent phagocytic and migration activity PMID: 21865318
    19. PPARgamma activation stimulates AQP3 expression, providing an additional mechanism by which PPAR activators regulate epidermal function. PMID: 21457357
    20. These results suggest that AQP3 may play a role in modulating dendritic cell population and migration PMID: 21871666
    21. The AQP1 and AQP3 genes were expressed in the secretary epithelia of the mouse prostate tissue, which suggests that AQP1 and AQP3 may play an important role in the secretion of prostatic fluid. PMID: 21735643
    22. aquaporin 3 is an essential membrane pathway for sperm regulatory volume decrease that balances the "trade-off" between sperm motility and cell swelling upon physiological hypotonicity PMID: 21135872
    23. The results indicate that AQP3 is certainly needed for the acquisition of immature oocytes' full growing potential within antral follicles. PMID: 20509986
    24. involvement of AQP3 in epidermal hyperplasia by a mechanism involving upregulated AQP3 expression and consequent enhancement of keratinocyte proliferation PMID: 21191421
    25. establish that AQP3 is required for Nox-derived H(2)O(2) signaling upon growth factor stimulation PMID: 20724658
    26. Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. PMID: 11880378
    27. first functional evidence for physiologically important glycerol transport by an aquaporin PMID: 12270942
    28. Phosphatidylglycerol, as a bioactive lipid, could potentially mediate the effects of the aquaporin 3-phospholipase D2 signaling module, with aquaporin 3 as a modulatory unit, in the regulation of keratinocyte function. PMID: 14675200
    29. upregulation of the UT-A2 urea transporter and the aquaporin 2 (AQP2) and AQP3 water channel transcripts but no change in other urea transporters or AQP in urea transporter B null mice PMID: 15100356
    30. Aquaporin-1, -3, and -5 dependent water-transporting properties of cornea and conjunctiva. PMID: 15557451
    31. AQP3 was detected in the alveolar epithelium and duct system. PMID: 15844003
    32. Mechanistic analysis of the altered skin phenotype in AQP3 deficiency suggested that the glycerol rather than the water transporting function of AQP3 is important in skin physiology PMID: 15966863
    33. an NH2-terminal sorting signal mediates the basolateral targeting of AQP3 PMID: 16135541
    34. The results suggest a novel role for AQP3 in non-urea solute concentration in the urine. PMID: 16525162
    35. Study demonstrates that during Enterobacterial infection, AQP2 and AQP3 are mislocalized from their normal location along cell membranes to the cell cytoplasm; his change correlates with the diarrhoea-like phenotype present in infected mice. PMID: 16889624
    36. AQP3 supplies PLD2 with glycerol for synthesizing PG, a lipid signal that promotes early keratinocyte differentiation PMID: 17597824
    37. AQP3 may thus be an important determinant in skin tumorigenesis and hence a novel target for tumor prevention and therapy PMID: 17967887
    38. Provide evidence for involvement of AQP3-facilitated water transport in epidermal cell migration and for AQP3-facilitated glycerol transport in epidermal cell proliferation. PMID: 17968524
    39. AQP3 might play an important role in controlling oocyte quality and a low in vitro fertilization rate of controlled ovarian hyperstimulation mice might, in part, result from reduced AQP3 expression and water permeability in mouse oocytes. PMID: 18209479
    40. There is little influence of AQP3 on keratinocyte differentiation, but there is support for the proposed involvement of AQP3-facilitated cell proliferation. PMID: 19184071
    41. aquaporins are common targets of gene expression in both allergen and IL-13 induced mouse models of asthma PMID: 19237298
    42. Blockade of MAPK14/11 negated the increase in Aqp 3 and 9 mRNA levels, whereas culture in a MAPK8 blocker did not in preimplantation embryo PMID: 19258345

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 組織特異性：
    Detected in principal cells in collecting ducts in kidney medulla (at protein level). Renal medulla and colon. Predominantly in the inner medulla. Expressed in basal layer of epidermal keratinocytes.
  • 數(shù)據(jù)庫鏈接：