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世界血友病日:提升認(rèn)知,積極預(yù)防和治療

世界血友病日

每年的4月17日為“世界血友病日”(World Hemophilia Day),設(shè)立這一國際紀(jì)念日旨在提高公眾對(duì)血友病的認(rèn)知,讓各界人士更多地了解和關(guān)愛血友病患者及其家庭,以及鼓勵(lì)科研創(chuàng)新以改善患者生活質(zhì)量。今年的主題是“認(rèn)識(shí)出血性疾病,積極預(yù)防和治療”。

血友病(Hemophilia),作為一種X染色體連鎖隱性遺傳病,主要影響男性群體,是由凝血因子 VIII 或 IX 的缺乏或功能障礙所引起的,主要包括血友病A(FⅧ缺乏)和血友病B(FⅨ缺乏)兩種疾病類型。由于缺乏關(guān)鍵的凝血因子,導(dǎo)致凝血過程受阻,無法有效形成血栓堵住傷口,血友病患者往往會(huì)出現(xiàn)不受控制的出血傾向,輕微的創(chuàng)傷或自發(fā)性出血事件都可能對(duì)他們?cè)斐蓢?yán)重威脅,甚至危及生命。女性雖然通常作為攜帶者,但在特殊情況下也可能表現(xiàn)出癥狀。

近年來,血友病的研究領(lǐng)域取得了顯著進(jìn)步。科學(xué)家們正積極探索新型治療方法,包括基因治療、長效凝血因子替代療法和小分子藥物研發(fā)等。其中,基因治療成為最激動(dòng)人心的方向之一,研究人員致力于通過病毒載體將正常的凝血因子基因引入患者體內(nèi),促使患者自身產(chǎn)生足夠的凝血因子,實(shí)現(xiàn)長期甚至永久性的治療效果。此外,針對(duì)凝血通路中的其他調(diào)控因子進(jìn)行藥物干預(yù),也成為新的藥物靶點(diǎn)探索熱點(diǎn)。

在藥物開發(fā)方面,已經(jīng)有多款長效凝血因子產(chǎn)品獲批上市,它們能夠更持久地維持血液中的凝血因子水平,減少患者注射頻率,極大地改善了患者的生活質(zhì)量。同時(shí),非因子療法,如反義寡核苷酸藥物和抗體療法等創(chuàng)新藥物,也在臨床試驗(yàn)階段展現(xiàn)出了良好的潛力,有望在未來提供更為多樣化的治療選擇。

華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品,鑒于血友病研究的重要性與迫切性,在此特別整理了一系列與血友病研究相關(guān)的20余種熱門靶點(diǎn)及相關(guān)試劑產(chǎn)品列舉如下,供您選擇:

血友病研究相關(guān)ELISA試劑盒:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
人載脂蛋白E(Apo-E)酶聯(lián)免疫試劑盒 CSB-E09748h APOE 15.62 ng/mL-1000 ng/mL 3.9 ng/mL
大鼠載脂蛋白E(Apo-E)酶聯(lián)免疫試劑盒 CSB-E09749r APOE 15.6 ng/mL-1000 ng/mL 15.6 ng/mL
小鼠載脂蛋白E(Apo-E)酶聯(lián)免疫試劑盒 CSB-E09750m APOE 6.25 ng/mL-400 ng/mL 1.56 ng/mL
豬載脂蛋白E(Apo-E)酶聯(lián)免疫試劑盒 CSB-E17889p APOE 31.25 ng/mL-2000 ng/mL 7.81 ng/mL
猴載脂蛋白E(APOE)酶聯(lián)免疫試劑盒 CSB-EL001936RH APOE 6.25 ng/mL-400 ng/mL 1.56 ng/mL
人CD4分子(CD4)酶聯(lián)免疫試劑盒 CSB-E08956h CD4 0.625 ng/mL-40 ng/mL 0.156 ng/mL
大鼠CD4分子(CD4)酶聯(lián)免疫試劑盒 CSB-E12928r CD4 0.78 U/mL-50 U/mL 0.195 U/mL
雞CD4分子(CD4)酶聯(lián)免疫試劑盒 CSB-E13114C CD4 3.125 ng/mL-800 ng/mL 3.125 ng/mL
人CD8分子(CD8)酶聯(lián)免疫試劑盒 CSB-E12707h CD8A 62.5 U/mL-4000 U/mL 15.6 U/mL
人凝血因子Ⅶ(FⅦ)酶聯(lián)免疫試劑盒 CSB-E12909h F7 0.312 ng/mL-20 ng/mL 0.078 ng/mL
小鼠凝血因子Ⅶ(FⅦ)酶聯(lián)免疫試劑盒 CSB-E17817m F7 0.45 ng/mL-30 ng/mL 0.11 ng/mL
大鼠凝血因子VII(F7)酶聯(lián)免疫試劑盒 CSB-EL007930RA F7 0.78 ng/mL-50 ng/mL 0.195 ng/mL
兔凝血因子VII(F7)酶聯(lián)免疫試劑盒 CSB-EL007930RB F7 3.9 ng/mL-250 ng/mL 1 ng/mL
小鼠凝血因子Ⅷ(FⅧ)酶聯(lián)免疫試劑盒 CSB-E13084m F8 0.312 ng/mL-20 ng/mL 0.078 ng/mL
人凝血因子VIII(FVⅢ)酶聯(lián)免疫試劑盒 CSB-E13861h F8 12.5 ng/mL-800 ng/mL 3.12 ng/mL
豬凝血因子VIII(FVIII)酶聯(lián)免疫試劑盒 CSB-E15000p F8 62.5 ng/mL-4000 ng/mL 15.62 ng/mL
人凝血因子Ⅸ(FⅨ)酶聯(lián)免疫試劑盒 CSB-E08443h F9 Request Information Request Information
人纖維蛋白原β鏈(FGB)酶聯(lián)免疫試劑盒 CSB-E09611h FGB 0.45 ng/ml-30 ng/ml 0.11 ng/ml
人胰島素樣生長因子2-mRNA結(jié)合蛋白3(IGF2BP3)酶聯(lián)免疫試劑盒 CSB-EL011092HU IGF2BP3 37.5 pg/mL-2400 pg/mL 9.37 pg/mL
小鼠白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E04627m-IS IL2 3.9 pg/ml-250 pg/ml 0.975 pg/ml
人白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E04626h IL2 31.25 pg/ml-2000 pg/ml. 7.81 pg/ml
小鼠白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E04627m IL2 31.25 pg/ml - 2000 pg/ml 7.8 pg/ml
大鼠白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E04628r IL2 6.25 pg/mL-400 pg/mL 1.56 pg/mL
豬白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E06783p IL2 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
兔子白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E08745Rb IL2 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
牛白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E09810b IL2 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
綿羊白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E11217Sh IL2 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
犬白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E11258c IL2 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
山羊白介素2(IL-2)酶聯(lián)免疫試劑盒 CSB-E12965G IL2 15.6 pg/mL-1000 pg/mL 3.9 pg/mL

血友病研究相關(guān)重組蛋白:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Mouse Apolipoprotein E (Apoe) CSB-BP001936MO Apoe Baculovirus N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human C-C chemokine receptor type 5 (CCR5) CSB-CF004844HU CCR5 in vitro E.coli expression system N-terminal 10xHis-tagged
Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial CSB-CF004935HU1 CD4 in vitro E.coli expression system N-terminal 6xHis-tagged
Recombinant Mouse Apolipoprotein E (Apoe) CSB-EP001936MO Apoe E.coli N-terminal 6xHis-tagged
Recombinant Rabbit Apolipoprotein E (APOE), partial CSB-EP001936RB APOE E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Rabbit Apolipoprotein E (APOE), partial CSB-EP001936RBb3 APOE E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Rabbit Apolipoprotein E (APOE), partial CSB-EP001936RBb7 APOE E.coli N-terminal 10xHis-B2M-tagged and C-terminal Myc-tagged
Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-EP004966BO CD8A E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-EP004966HU CD8A E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Prothrombin (F2) CSB-EP007923HU F2 E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Coagulation factor VII (F7), partial CSB-EP007930HU F7 E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Fibrinogen beta chain (FGB), partial CSB-EP008608HU FGB E.coli N-terminal 6xHis-tagged
Recombinant Human Interleukin-2 (IL2) CSB-EP011629HU IL2 E.coli N-terminal GST-tagged
Recombinant Human Interleukin-2 (IL2) CSB-EP011629HUc7 IL2 E.coli C-terminal 6xHis-tagged
Recombinant Macaca mulatta Interleukin-2 (IL2) CSB-EP011629MOW IL2 E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Rabbit Interleukin-2 (IL2) CSB-EP011629RB IL2 E.coli N-terminal 6xHis-tagged
Recombinant Mouse Apolipoprotein E (Apoe) CSB-MP001936MO Apoe Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-MP004966HU CD8A Mammalian cell N-terminal 6xHis-Myc-tagged
Recombinant Mouse Apolipoprotein E (Apoe) CSB-YP001936MO Apoe Yeast N-terminal 6xHis-tagged
Recombinant Mouse C-C chemokine receptor type 5 (Ccr5), partial CSB-YP004844MO Ccr5 Yeast N-terminal 6xHis-tagged

血友病研究相關(guān)抗體:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
A1BG Antibody CSB-PA001001LA01HU A1BG Human ELISA, IHC
A1BG Antibody CSB-PA004674 A1BG Human ELISA, WB
A1BG Antibody CSB-PA001001GA01HU A1BG Human ELISA, WB, IHC
A1BG Antibody CSB-PA278727 A1BG Human ELISA, WB
A1BG Antibody CSB-PA289003 A1BG Human ELISA, WB
ABO Antibody CSB-PA001110LA01HU ABO Human, Mouse ELISA, WB
ABO Antibody CSB-PA048521 ABO Human ELISA, IHC
ABO Antibody CSB-PA210249 ABO Human ELISA, IHC
APOE Antibody CSB-PA07599A0Rb APOE Human ELISA, IHC, IF
APOE Antibody CSB-PA009485 APOE Human, Mouse, Rat ELISA, WB, IHC
APOE Antibody CSB-PA009486 APOE Human ELISA, WB
APOE Antibody CSB-PA227407 APOE Human ELISA, WB
Ccr5 Antibody CSB-PA004844LA01MO Ccr5 Mouse ELISA
CCR5 Antibody CSB-PA004844LA01HU CCR5 Human, Mouse ELISA, WB, IF
Phospho-CCR5 (S349) Antibody CSB-PA000640 CCR5 Human ELISA, WB
CCR5 Antibody CSB-PA006994 CCR5 Human ELISA, WB
Phospho-CCR5 (S336) Antibody CSB-PA006995 CCR5 Human, Mouse, Rat ELISA, WB
CCR5 Antibody CSB-PA006993 CCR5 Human, Mouse, Rat ELISA, IHC
CCR5 Antibody CSB-PA792075 CCR5 Human ELISA, WB, IHC
CCR5 Antibody CSB-PA004844GA01HU CCR5 Human, Mouse, Rat ELISA, WB