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國(guó)際癲癇關(guān)愛日:關(guān)注癲癇共病

癲癇

每年的6月28日被定為“國(guó)際癲癇關(guān)愛日”,旨在呼吁社會(huì)關(guān)注癲癇患者及家屬,提高公眾對(duì)癲癇病的認(rèn)識(shí),規(guī)范行業(yè)診療行為,提醒患者通過正規(guī)途徑正確治療。今年“關(guān)愛日”的宣傳主題確定為“關(guān)注癲癇共病”(Pay Attention To The Comorbidities of Epilepsy)。

癲癇是一種以反復(fù)發(fā)作的癲癇發(fā)作為特征的慢性神經(jīng)系統(tǒng)疾病。癲癇發(fā)作由腦部神經(jīng)元異常放電引起,其癥狀多種多樣,包括身體抽搐、意識(shí)喪失、感覺異常甚至行為和情緒的改變。根據(jù)發(fā)作時(shí)的特征,可將其分為全面性癲癇和局灶性癲癇。

癲癇的發(fā)病機(jī)制復(fù)雜多樣,通常涉及遺傳、腦部結(jié)構(gòu)異常、腦損傷、代謝異常等多種因素?,F(xiàn)代醫(yī)學(xué)研究揭示,癲癇發(fā)作是由于大腦神經(jīng)網(wǎng)絡(luò)的異常興奮性增加或抑制性減少所導(dǎo)致。一方面,某些基因突變會(huì)影響離子通道功能,導(dǎo)致神經(jīng)元膜電位不穩(wěn)定;另一方面,腦部感染、外傷、缺氧、腫瘤等外部因素也可能觸發(fā)或加劇癲癇的發(fā)生。此外,神經(jīng)遞質(zhì)失衡、神經(jīng)膠質(zhì)細(xì)胞功能異常也被認(rèn)為是癲癇發(fā)病機(jī)制中的重要因素。

在癲癇的治療方面,傳統(tǒng)的抗癲癇藥物主要通過調(diào)節(jié)神經(jīng)遞質(zhì)水平或抑制異常電活動(dòng)來控制癲癇發(fā)作。然而,這些藥物對(duì)某些患者可能無(wú)效,且可能導(dǎo)致嚴(yán)重的副作用。因此,探索新的治療策略和藥物靶點(diǎn)成為當(dāng)前研究的重要方向之一。

近年來,關(guān)于癲癇的研究涌現(xiàn)出許多新的突破。研究發(fā)現(xiàn),炎癥反應(yīng)和免疫細(xì)胞的異常活動(dòng)可能導(dǎo)致神經(jīng)元的過度興奮和癲癇發(fā)作,因此,調(diào)節(jié)免疫系統(tǒng)可能成為一種新的治療策略。一些實(shí)驗(yàn)性治療方法,如使用抗炎藥物或免疫調(diào)節(jié)劑(如IL-1β抑制劑),已在動(dòng)物模型中顯示出潛力,成為治療難治性癲癇的新方向。

此外,基因治療和精準(zhǔn)醫(yī)學(xué)在癲癇研究中的應(yīng)用也取得了顯著進(jìn)展。針對(duì)特定基因突變的藥物,如針對(duì)Dravet綜合征(嬰兒嚴(yán)重肌陣攣性癲癇)的SCN1A基因治療,正逐步進(jìn)入臨床試驗(yàn)階段,為遺傳性癲癇患者帶來了新的希望。

與此同時(shí),一些新型的抗癲癇藥物正在研發(fā)中,這些藥物針對(duì)特定的離子通道和受體,例如鈉離子通道、鉀離子通道和GABA受體等。這些新藥有望提供更高的療效和更少的副作用,從而改善患者的生活質(zhì)量。

華美生物長(zhǎng)期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品,鑒于癲癇病研究的重要性與迫切性,在此特別整理了一系列與癲癇病研究相關(guān)的熱門靶點(diǎn)及相關(guān)試劑產(chǎn)品列舉如下,供您選擇:

癲癇研究相關(guān)ELISA試劑盒:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
人RACα絲氨酸/蘇氨酸蛋白激酶(AKT1)酶聯(lián)免疫試劑盒 CSB-EL001553HU AKT1 0.312 ng/mL-20 ng/mL 0.078 ng/mL
大鼠淀粉樣βA4蛋白(APP)酶聯(lián)免疫試劑盒 CSB-EL001950RA APP 15.6 ng/mL-1000 ng/mL 3.9 ng/mL
人腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-E04501h BDNF 0.3125 ng/mL-20 ng/mL 0.063 ng/mL
大鼠腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-E04504r BDNF 0.312 ng/mL-20 ng/mL 0.078 ng/mL
小鼠腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-E04505m BDNF 15.6 pg/mL-1000 pg/mL 1.95 pg/mL
豬腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-EL002655PI BDNF 9.375 ng/mL-600 ng/mL 2.35 ng/mL
猴腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-EL002655RH BDNF 0.78 ng/mL-50 ng/mL 0.195 ng/mL
人神經(jīng)膠質(zhì)纖維酸性蛋白(GFAP)酶聯(lián)免疫試劑盒 CSB-E08601h GFAP 0.625 ng/mL-40 ng/mL 0.156 ng/mL
大鼠神經(jīng)膠質(zhì)纖維酸性蛋白(GFAP)酶聯(lián)免疫試劑盒 CSB-E08602r GFAP 78 pg/mL-5000 pg/mL 19.5 pg/mL
小鼠神經(jīng)膠質(zhì)纖維酸性蛋白(GFAP)酶聯(lián)免疫試劑盒 CSB-E08603m GFAP 3.12 pg/mL-200 pg/mL 0.78 pg/mL
豬神經(jīng)膠質(zhì)纖維酸性蛋白(GFAP)酶聯(lián)免疫試劑盒 CSB-E14950p GFAP 0.1 ng/mL-20 ng/mL 0.05 ng/mL
人白介素1β (IL-1β)酶聯(lián)免疫試劑盒 CSB-E08053h-IS IL1B 2.344 pg/ml-150 pg/ml 0.586 pg/ml
小鼠白介素1β (IL-1β)酶聯(lián)免疫試劑盒 CSB-E08054m-IS IL1B 12.5 pg/ml-800 pg/ml 3.125 pg/ml
豬白介素1β (IL-1β)酶聯(lián)免疫試劑盒 CSB-E06782p IL1B 3.9 pg/mL-250 pg/mL 0.975 pg/mL
兔子白介素1β (IL-1β)酶聯(lián)免疫試劑盒 CSB-E06900Rb IL1B 7.8 pg/mL-500 pg/mL 1.95 pg/mL
人白介素1β (IL-1β)酶聯(lián)免疫試劑盒 CSB-E08053h IL1B 7.8 pg/ml - 500 pg/ml 1.95 pg/ml
小鼠白介素1β (IL-1β)酶聯(lián)免疫試劑盒 CSB-E08054m IL1B Request Information Request Information
大鼠白介素1β (IL-1β)酶聯(lián)免疫試劑盒 CSB-E08055r IL1B 0.156 ng/ml-10 ng/ml. 0.039 ng/ml.
綿羊白介素1β(IL-1β)酶聯(lián)免疫試劑盒 CSB-E10115Sh IL1B 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
牛白介素1β(IL-1β)酶聯(lián)免疫試劑盒 CSB-E12986B IL1B 62.5 pg/mL-4000 pg/mL 15.6 pg/mL

癲癇研究相關(guān)重組蛋白:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Marmota monax Tumor necrosis factor (TNF), partial CSB-BP523593MQG TNF Baculovirus N-terminal 10xHis-tagged
Recombinant Human RAC-alpha serine/threonine-protein kinase (AKT1) CSB-EP001553HU AKT1 E.coli N-terminal GST-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF) CSB-EP002655HU BDNF E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF), partial CSB-EP002655HU1 BDNF E.coli N-terminal GST-tagged
Recombinant Danio rerio Glial fibrillary acidic protein (gfap) CSB-EP009369DIL gfap E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Mouse Glial fibrillary acidic protein (Gfap) CSB-EP009369MO GFAP E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Interleukin-1 beta (IL1B) CSB-EP011614HU IL1B E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Interleukin-1 beta (IL1B) CSB-EP011614HUe0 IL1B E.coli N-terminal GST-tagged
Recombinant Sheep Interleukin-1 beta (IL1B) CSB-EP011614SH IL1B E.coli N-terminal 6xHis-tagged
Recombinant Human Interleukin-6 (IL6) CSB-EP011664HU IL6 E.coli N-terminal 6xHis-tagged
Recombinant Sheep Interleukin-6 (IL6) CSB-EP011664SH IL6 E.coli N-terminal GST-tagged
Recombinant Macaca mulatta Microtubule-associated protein tau (MAPT) CSB-EP013481MOW MAPT E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Rat Microtubule-associated protein tau (Mapt) CSB-EP013481RA Mapt E.coli N-terminal 6xHis-tagged
Recombinant Human Parvalbumin alpha (PVALB) CSB-EP019092HU PVALB E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Bovie Tumor necrosis factor (TNF), partial CSB-EP023955BO TNF E.coli N-terminal 6xHis-tagged
Recombinant Bovie Tumor necrosis factor (TNF), partial CSB-EP023955BOe0 TNF E.coli N-terminal GST-tagged
Recombinant Human Tumor necrosis factor (TNF), partial CSB-EP023955HU TNF E.coli N-terminal 6xHis-tagged
Recombinant Mouse Tumor necrosis factor (Tnf), partial CSB-EP023955MO1 Tnf E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Sheep Tumor necrosis factor (TNF), partial CSB-EP023955SH TNF E.coli N-terminal GST-tagged
Recombinant Danio rerio Interleukin-1 (il1b) CSB-EP2346DIL il1b E.coli N-terminal 6xHis-tagged

癲癇研究相關(guān)抗體:

● 重組抗體:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
Phospho-AKT1 (T450) Recombinant Monoclonal Antibody CSB-RA001553A450phHU AKT1 Human ELISA, WB
Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody CSB-RA001553A473phHU AKT1 Human ELISA, WB, IHC, IF, IP
AKT1 Recombinant Monoclonal Antibody CSB-RA917625A0HU AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
APP Recombinant Monoclonal Antibody CSB-RA994273A0HU APP Human, Mouse, Rat ELISA, WB, IF
BDNF Recombinant Monoclonal Antibody CSB-RA989910A0HU BDNF Human, Mouse ELISA, WB
GFAP Recombinant Monoclonal Antibody CSB-RA241995A0HU GFAP Human ELISA, FC
GFAP Recombinant Monoclonal Antibody CSB-RA009369MA1HU GFAP Human, Mouse, Rat ELISA, WB, IHC, IF, FC
IL6 Recombinant Monoclonal Antibody CSB-RA011664MA1HU IL6 Human ELISA
INS Recombinant Monoclonal Antibody CSB-RA584163A0HU INS Human ELISA, IHC
Phospho-MAPT (T231) Recombinant Monoclonal Antibody CSB-RA013481A231phHU MAPT Human ELISA, WB
Phospho-MAPT (S396) Recombinant Monoclonal Antibody CSB-RA013481A396phHU MAPT Human ELISA, WB
Phospho-MAPT (S324) Recombinant Monoclonal Antibody CSB-RA013481A324phHU MAPT Human ELISA, IF
MAPT Recombinant Monoclonal Antibody CSB-RA246354A0HU MAPT Human ELISA, IHC
MAPT Recombinant Monoclonal Antibody CSB-RA013481A1HU MAPT Mouse, Macaca mulatta ELISA
Phospho-MAPT (S199) Recombinant Monoclonal Antibody CSB-RA051594A0HU MAPT Human ELISA, IHC, FC
Phospho-MAPT (S404) Recombinant Monoclonal Antibody CSB-RA901354A0HU MAPT Human ELISA, IHC
Phospho-MAPT (S214) Recombinant Monoclonal Antibody CSB-RA050476A0HU MAPT Human ELISA, IHC
Phospho-MAPT (S202) Recombinant Monoclonal Antibody CSB-RA082445A0HU MAPT Human ELISA, FC
MAPT Recombinant Monoclonal Antibody CSB-RA013481MA1HU MAPT Human ELISA, FC
Phospho-MTOR (S2481) Recombinant Monoclonal Antibody CSB-RA008968A2481phHU MTOR Human ELISA, WB, IF
Phospho-MTOR (S2448) Recombinant Monoclonal Antibody CSB-RA008968A2448phHU MTOR Human ELISA, WB, IHC, IF

● 單克隆抗體:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
AKT1 Monoclonal Antibody CSB-MA011037 AKT1 Human,Mouse,Pig,Rat ELISA, WB
APP Monoclonal Antibody CSB-MA0019501A0m APP Human, Mouse ELISA, WB, IHC, IF
GFAP Monoclonal Antibody CSB-MA009369A0m GFAP Human, Mouse, Rat ELISA, WB, IHC, IF, FC
GFAP Monoclonal Antibody CSB-MA000216 GFAP Rat,Mouse ELISA, WB
GFAP Monoclonal Antibody CSB-MA293354 GFAP Human ELISA, IHC
IL1B Monoclonal Antibody CSB-MA065741A0m IL1B Human ELISA
IL1B Monoclonal Antibody CSB-MA010884 IL1B Human ELISA, WB, IHC, ICC
IL6 Monoclonal Antibody CSB-MA067571A0m IL6 Human ELISA, WB, IHC
TNF Monoclonal Antibody CSB-MA084771A0m TNF Bovine ELISA
TNF Monoclonal Antibody CSB-MA080271 TNF Human,Mouse,Rat ELISA, WB, IHC
TNF Monoclonal Antibody CSB-MA080272 TNF Human,Mouse,Rat ELISA, WB, IHC

● 多克隆抗體:

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
AKT1 Antibody CSB-PA15905A0Rb AKT1 Human ELISA, WB, IHC, IF, IP
AKT1 Antibody CSB-PA000852 AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
Phospho-AKT1 (S124) Antibody CSB-PA008118 AKT1 Human, Mouse, Rat ELISA, WB, IHC
Phospho-AKT1 (T72) Antibody CSB-PA008120 AKT1 Human, Mouse, Rat ELISA, WB, IHC
AKT1 Antibody CSB-PA008122 AKT1 Human, Mouse, Rat ELISA, IHC
AKT1 Antibody CSB-PA080256 AKT1 Human, Mouse, Rat WB
Phospho-AKT1 (S129) Antibody CSB-PA000645 AKT1 Human, Mouse, Rat ELISA, WB
Phospho-AKT1 (T308) Antibody CSB-PA000657 AKT1 Human, Mouse, Rat ELISA, WB
Phospho-AKT1 (S473) Antibody CSB-PA000732 AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
AKT1 Antibody CSB-PA000851 AKT1 Human, Mouse, Rat, Monkey ELISA, WB, IHC, IF
Phospho-AKT1 (S246) Antibody CSB-PA000465 AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
Phospho-AKT1 (T450) Antibody CSB-PA000468 AKT1 Human, Mouse, Rat ELISA, WB, IHC
Phospho-AKT1 (Y326) Antibody CSB-PA000649 AKT1 Human, Mouse, Rat ELISA, WB
Phospho-AKT1 (Y474) Antibody CSB-PA000704 AKT1 Human, Mouse, Rat, Monkey ELISA, WB, IHC
AKT1 Antibody CSB-PA000855 AKT1 Human, Mouse, Rat ELISA, WB, IHC
AKT1 Antibody CSB-PA000849 AKT1 Human, Mouse, Rat ELISA, WB, IHC
AKT1 Antibody CSB-PA001553GA01HU AKT1 Human ELISA, WB
AKT1 Antibody CSB-PA098004 AKT1 Human, Mouse, Rat ELISA, IHC
AKT1 Antibody CSB-PA721992 AKT1 Human, Mouse, Rat ELISA, WB
AKT1 Antibody CSB-PA942120 AKT1 Human, Mouse, Rat ELISA, WB