每年的4月25日是“世界防治瘧疾日”(World Malaria Day),這一天旨在喚起全球?qū)汞懠驳囊庾R,提高人們對這一疾病的認知,加強合作,推動實現(xiàn)全球瘧疾零負擔的愿景。作為全球范圍內(nèi)最為致命的傳染病之一,瘧疾每年造成全球幾十萬人的死亡,尤其對兒童和孕婦構(gòu)成嚴重威脅。因此,這一天不僅是紀念抗擊瘧疾的斗爭歷程,更是為了倡導科學進步,強化預防措施,提高診斷和治療水平。今年的主題是“防止瘧疾再傳播,持續(xù)鞏固消除成果”。
瘧疾(Malaria)是由瘧原蟲屬寄生蟲引起的一種可致命的傳染病,當攜帶瘧原蟲的雌性按蚊叮咬人體時,會將瘧原蟲的孢子體注入人體血液中,這些孢子體隨后侵入肝細胞發(fā)育成裂殖體,并進一步侵犯紅細胞,引發(fā)周期性的發(fā)熱、寒戰(zhàn)、出汗和頭痛等癥狀。按照感染人類的不同瘧原蟲種類的不同,將瘧疾分為日瘧、卵形瘧、三日瘧和惡性瘧等類型。
目前,瘧疾治療通常是根據(jù)不同類型的瘧疾針對性的選用藥物治療,無需手術。在藥物研發(fā)方面,鑒于瘧疾對傳統(tǒng)抗瘧藥物如氯喹和磺胺多辛-乙胺嘧啶等的耐藥性增加,科研人員正致力于尋找和驗證新的藥物靶點。其中,針對瘧原蟲生命周期特定階段的藥物設計受到特別關注,比如抑制瘧原蟲在肝臟期發(fā)育的藥物,或是阻止瘧原蟲在紅細胞內(nèi)繁殖的化合物。在過去的幾年里,單克隆抗體療法也展現(xiàn)出潛力,能夠特異性地結(jié)合并清除瘧原蟲,減少瘧疾的傳播和發(fā)病。
此外,瘧疾疫苗的研發(fā)一直是全球健康領域的熱點。盡管首個獲批用于兒童的RTS,S/AS01(商品名Mosquirix)瘧疾疫苗已經(jīng)在部分高風險地區(qū)投入使用,但它提供的保護效力有限且不持久。因此,科研人員正在探索更為有效的疫苗策略,包括基于蛋白質(zhì)的多表位疫苗、RNA疫苗及DNA疫苗等,力求提升疫苗誘導的免疫反應強度和持久性。
華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品,鑒于瘧疾研究的重要性與迫切性,在此特別整理了一系列與瘧疾研究相關的20余種熱門靶點及相關試劑產(chǎn)品列舉如下,供您選擇:
瘧疾研究相關ELISA試劑盒:
產(chǎn)品名稱 | 貨號 | 靶點 | 檢測范圍 | 靈敏度 |
---|---|---|---|---|
大鼠血管緊張素轉(zhuǎn)化酶2(ACE2)酶聯(lián)免疫試劑盒 | CSB-E14308r | ACE2 | 0.02 ng/ml - 20 ng/ml | 0.02 ng/ml |
人血管緊張素轉(zhuǎn)化酶2(ACE2)酶聯(lián)免疫試劑盒 | CSB-E04489h | ACE2 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
小鼠血管緊張素轉(zhuǎn)化酶2(ACE2)酶聯(lián)免疫試劑盒 | CSB-E17204m | ACE2 | 6.25 pg/mL-400 pg/mL | 1.56 pg/mL |
人RACα絲氨酸/蘇氨酸蛋白激酶(AKT1)酶聯(lián)免疫試劑盒 | CSB-EL001553HU | AKT1 | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
牛白蛋白(ALB)酶聯(lián)免疫試劑盒 | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
小鼠白蛋白酶聯(lián)免疫試劑盒 | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
犬白蛋白(Alb)酶聯(lián)免疫試劑盒 | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
綿羊白蛋白酶聯(lián)免疫試劑盒 | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
馬白蛋白酶聯(lián)免疫試劑盒 | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
豬白蛋白酶聯(lián)免疫試劑盒 | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
山羊白蛋白(Alb)酶聯(lián)免疫試劑盒 | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
豚鼠白蛋白(ALB)酶聯(lián)免疫試劑盒 | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
兔白蛋白酶聯(lián)免疫試劑盒 | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
人CD4分子(CD4)酶聯(lián)免疫試劑盒 | CSB-E08956h | CD4 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
大鼠CD4分子(CD4)酶聯(lián)免疫試劑盒 | CSB-E12928r | CD4 | 0.78 U/mL-50 U/mL | 0.195 U/mL |
雞CD4分子(CD4)酶聯(lián)免疫試劑盒 | CSB-E13114C | CD4 | 3.125 ng/mL-800 ng/mL | 3.125 ng/mL |
人CD8分子(CD8)酶聯(lián)免疫試劑盒 | CSB-E12707h | CD8A | 62.5 U/mL-4000 U/mL | 15.6 U/mL |
小鼠C反應蛋白(CRP)酶聯(lián)免疫試劑盒 | CSB-E07923m(1) | CRP | 5 ng/mL-4000 ng/mL | 5 ng/mL |
兔子C反應蛋白(CRP)酶聯(lián)免疫試劑盒 | CSB-E06847Rb | CRP | 7.8 pg/mL-2000 pg/mL | 2 pg/mL |
大鼠C反應蛋白(CRP)酶聯(lián)免疫試劑盒 | CSB-E07922r | CRP | 31.25 ng/mL-2000 ng/mL | 7.81 ng/mL |
瘧疾研究相關重組蛋白:
產(chǎn)品名稱 | 貨號 | 靶點 | 來源 | 蛋白標簽 |
---|---|---|---|---|
Recombinant Mouse Serum albumin (Alb) | CSB-BP001561MO | Alb | Baculovirus | C-terminal 9xHis-tagged |
Recombinant Macaca mulatta Interleukin-10 (IL10) | CSB-BP011580MOW | IL10 | Baculovirus | N-terminal 10xHis-tagged and C-terminal myc-tagged |
Recombinant Macaca mulatta Interleukin-10 (IL10) | CSB-BP011580MOWd7 | IL10 | Baculovirus | C-terminal 10xHis-tagged |
Recombinant Marmota monax Tumor necrosis factor (TNF), partial | CSB-BP523593MQG | TNF | Baculovirus | N-terminal 10xHis-tagged |
Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial | CSB-CF004935HU1 | CD4 | in vitro E.coli expression system | N-terminal 6xHis-tagged |
Recombinant Human RAC-alpha serine/threonine-protein kinase (AKT1) | CSB-EP001553HU | AKT1 | E.coli | N-terminal GST-tagged |
Recombinant Dog Serum albumin (ALB) | CSB-EP001561DO | ALB | E.coli | N-terminal 6xHis-tagged |
Recombinant Macaca fascicularis albumin (ALB) | CSB-EP001561MOV | ALB | E.coli | N-terminal 6xHis-SUMO-tagged |
Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A), partial | CSB-EP004966BO | CD8A | E.coli | N-terminal 6xHis-SUMO-tagged |
Recombinant Human T-cell surface glycoprotein CD8 alpha chain (CD8A), partial | CSB-EP004966HU | CD8A | E.coli | N-terminal 6xHis-SUMO-tagged |
Recombinant Human Epidermal growth factor receptor (EGFR), partial | CSB-EP007479HU3 | EGFR | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | CSB-EP007763HU | ERBB2 | E.coli | N-terminal 6xHis-tagged |
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | CSB-EP007763HU1 | ERBB2 | E.coli | N-terminal 6xHis-tagged |
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | CSB-EP007763HU3 | ERBB2 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
Recombinant Human Alanine aminotransferase 1 (GPT) | CSB-EP009864HU | GPT | E.coli | N-terminal 6xHis-tagged |
Recombinant Chicken Interferon gamma (IFNG) | CSB-EP011050CH | IFNG | E.coli | N-terminal GST-tagged |
Recombinant Human Interferon gamma (IFNG) | CSB-EP011050HU | IFNG | E.coli | N-terminal 6xHis-tagged |
Recombinant Mouse Interferon gamma (Ifng), partial | CSB-EP011050MO1 | Ifng | E.coli | N-terminal 6xHis-tagged |
Recombinant Marmota monax Interferon gamma (IFNG) | CSB-EP011050MQG | IFNG | E.coli | N-terminal 6xHis-tagged |
Recombinant Rat Interferon gamma (Ifng) | CSB-EP011050RA | Ifng | E.coli | N-terminal GST-tagged |
瘧疾研究相關抗體:
● 重組抗體:
產(chǎn)品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
---|---|---|---|---|
Phospho-AKT1 (T450) Recombinant Monoclonal Antibody | CSB-RA001553A450phHU | AKT1 | Human | ELISA, WB |
Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody | CSB-RA001553A473phHU | AKT1 | Human | ELISA, WB, IHC, IF, IP |
AKT1 Recombinant Monoclonal Antibody | CSB-RA917625A0HU | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD8A Recombinant Monoclonal Antibody | CSB-RA934881A0HU | CD8A | Human | ELISA, WB, IHC, IP |
CRP Recombinant Monoclonal Antibody | CSB-RA988767A0HU | CRP | Human | ELISA, IHC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody | CSB-RA588766A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA2HU | ERBB2 | Human | ELISA, IHC |
IL10 Recombinant Monoclonal Antibody | CSB-RA011580A0HU | IL10 | Human | ELISA |
IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | IL6 | Human | ELISA |
INS Recombinant Monoclonal Antibody | CSB-RA584163A0HU | INS | Human | ELISA, IHC |
Phospho-MTOR (S2481) Recombinant Monoclonal Antibody | CSB-RA008968A2481phHU | MTOR | Human | ELISA, WB, IF |
Phospho-MTOR (S2448) Recombinant Monoclonal Antibody | CSB-RA008968A2448phHU | MTOR | Human | ELISA, WB, IHC, IF |
● 單克隆抗體:
產(chǎn)品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
---|---|---|---|---|
AKT1 Monoclonal Antibody | CSB-MA011037 | AKT1 | Human,Mouse,Pig,Rat | ELISA, WB |
ALB Monoclonal Antibody | CSB-MA076752 | ALB | Human | ELISA, WB, IHC |
CD4 Monoclonal Antibody | CSB-MA000228 | CD4 | Human,Mouse,Rat | ELISA, IHC |
CD4 Monoclonal Antibody,Purified | CSB-MA783233 | CD4 | Human | ELISA, FC |
CD8A Monoclonal Antibody,Purified | CSB-MA927984 | CD8A | Human | ELISA, FC |
CRP Monoclonal Antibody | CSB-MA027411E0m | CRP | Human | ELISA, IHC |
CXCL8 Monoclonal Antibody | CSB-MA083271A0m | CXCL8 | Human | ELISA, IHC |
EGFR Monoclonal Antibody | CSB-MA000199 | EGFR | Human | ELISA, WB, IHC, IF |
EGFR Monoclonal Antibody | CSB-MA000293 | EGFR | Human | ELISA, WB |
ERBB2 Monoclonal Antibody | CSB-MA000200 | ERBB2 | Human,Mouse,Rat | ELISA, WB, IHC |
ERBB2 Monoclonal Antibody | CSB-MA000237 | ERBB2 | Human | ELISA, WB |
ERBB2 Monoclonal Antibody | CSB-MA172796 | ERBB2 | Human | ELISA, WB, IHC |
IFNG Monoclonal Antibody | CSB-MA065241A0m | IFNG | Human | ELISA, IHC |
IL6 Monoclonal Antibody | CSB-MA067571A0m | IL6 | Human | ELISA, WB, IHC |
TNF Monoclonal Antibody | CSB-MA084771A0m | TNF | Bovine | ELISA |
TNF Monoclonal Antibody | CSB-MA080271 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
TNF Monoclonal Antibody | CSB-MA080272 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
● 多克隆抗體:
產(chǎn)品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
---|---|---|---|---|
ACE2 Antibody | CSB-PA866317LA01HU | ACE2 | Human | ELISA, IHC, IF |
Ace2 Antibody | CSB-PA688690OA01RA | Ace2 | Rat | ELISA, WB |
ACE2 Antibody | CSB-PA040178 | ACE2 | Human, Mouse | ELISA, WB |
ACE2 Antibody | CSB-PA001150GA01HU | ACE2 | Human, Mouse, Rat | ELISA, WB |
ACE2 Antibody | CSB-PA111496 | ACE2 | Human | ELISA, IHC |
ACE2 Antibody | CSB-PA025395 | ACE2 | Human, Mouse, Rat | ELISA, IHC |
ACE2 Antibody | CSB-PA445794 | ACE2 | Human, Mouse, Rat | ELISA, IHC |
AKT1 Antibody | CSB-PA15905A0Rb | AKT1 | Human | ELISA, WB, IHC, IF, IP |
AKT1 Antibody | CSB-PA000852 | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
Phospho-AKT1 (S124) Antibody | CSB-PA008118 | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC |
Phospho-AKT1 (T72) Antibody | CSB-PA008120 | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC |
AKT1 Antibody | CSB-PA008122 | AKT1 | Human, Mouse, Rat | ELISA, IHC |
AKT1 Antibody | CSB-PA080256 | AKT1 | Human, Mouse, Rat | WB |
Phospho-AKT1 (S129) Antibody | CSB-PA000645 | AKT1 | Human, Mouse, Rat | ELISA, WB |
Phospho-AKT1 (T308) Antibody | CSB-PA000657 | AKT1 | Human, Mouse, Rat | ELISA, WB |
Phospho-AKT1 (S473) Antibody | CSB-PA000732 | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
AKT1 Antibody | CSB-PA000851 | AKT1 | Human, Mouse, Rat, Monkey | ELISA, WB, IHC, IF |
Phospho-AKT1 (S246) Antibody | CSB-PA000465 | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
Phospho-AKT1 (T450) Antibody | CSB-PA000468 | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC |
Phospho-AKT1 (Y326) Antibody | CSB-PA000649 | AKT1 | Human, Mouse, Rat | ELISA, WB |