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世界自閉癥意識日:點亮孤獨的“星星”

世界自閉癥意識日

2007年12月,聯(lián)合國大會通過了一項決議,即從2008年開始,將每年的4月2日設(shè)立為“世界自閉癥意識日”(World Autism Awareness Day),設(shè)立這一國際日的主要目的是增強(qiáng)全球?qū)ψ蚤]癥及相關(guān)研究、診斷以及自閉癥患者的關(guān)注,并強(qiáng)調(diào)早期識別和干預(yù)治療的重要性。2024年世界自閉癥意識日的主題是“色彩”,旨在尊重和珍視自閉癥群體的各種能力和經(jīng)歷。

自閉癥(Autism Spectrum Disorder, ASD)并不是一種罕見病,根據(jù)美國疾病控制預(yù)防中心(CDC)在2023年3月發(fā)布的自閉癥患病篩查數(shù)據(jù)顯示,每36名8歲兒童中就有1名患有自閉癥。更有數(shù)據(jù)統(tǒng)計,中國的新生兒自閉癥發(fā)病率達(dá)到了1%,患病總?cè)藬?shù)超過一千萬。自閉癥的癥狀表現(xiàn)多樣,從輕微的語言發(fā)展遲緩到嚴(yán)重的社交障礙不等,每個人的癥狀嚴(yán)重程度和具體表現(xiàn)都有所差異,因此也被稱為“孤獨癥譜系障礙”,而在中國,患有自閉癥的兒童也被稱作“星星的孩子”。

自閉癥屬于神經(jīng)發(fā)育障礙性疾病,其病因至今尚未完全明確,但研究表明,遺傳因素和環(huán)境因素的交互作用極有可能導(dǎo)致自閉癥的發(fā)生。

近年來,科研人員在自閉癥領(lǐng)域的研究熱點集中在了遺傳學(xué)、神經(jīng)生物學(xué)、免疫學(xué)等多個維度,其中不乏令人振奮的新靶點和研究方向。

例如,針對自閉癥相關(guān)的遺傳變異,除了最為人熟知的自閉癥單基因成因FMR1以外,科學(xué)家們還重點研究了SHANK3、NLGN3/4X等基因突變與自閉癥之間的關(guān)聯(lián),這些基因編碼的蛋白質(zhì)在神經(jīng)元連接與信號傳遞中發(fā)揮著關(guān)鍵作用。據(jù)報道,超過 1,000 個基因的變化被認(rèn)為與自閉癥相關(guān),但其中大部分基因還尚未得到證實。與此同時,神經(jīng)遞質(zhì)系統(tǒng),尤其是血清素、多巴胺等在自閉癥發(fā)病機(jī)制中的作用也引起了廣泛的關(guān)注和深入研究。

華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品,特別整理了與自閉癥研究相關(guān)的20余種熱門靶點及相關(guān)試劑產(chǎn)品列舉如下,供您選擇:

自閉癥研究相關(guān)ELISA試劑盒:

產(chǎn)品名稱 貨號 靶點 檢測范圍 靈敏度
人腦源性神經(jīng)營養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-E04501h BDNF 0.3125 ng/mL-20 ng/mL 0.063 ng/mL
大鼠腦源性神經(jīng)營養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-E04504r BDNF 0.312 ng/mL-20 ng/mL 0.078 ng/mL
小鼠腦源性神經(jīng)營養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-E04505m BDNF 15.6 pg/mL-1000 pg/mL 1.95 pg/mL
豬腦源性神經(jīng)營養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-EL002655PI BDNF 9.375 ng/mL-600 ng/mL 2.35 ng/mL
猴腦源性神經(jīng)營養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒 CSB-EL002655RH BDNF 0.78 ng/mL-50 ng/mL 0.195 ng/mL
人上皮調(diào)節(jié)蛋白(EREG)酶聯(lián)免疫試劑盒 CSB-EL007779HU EREG 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
人脆性X智力低下蛋白1(FMR1)酶聯(lián)免疫試劑盒 CSB-EL008756HU FMR1 15.6 pg/mL-1000 pg/mL 3.9 pg/mL

自閉癥研究相關(guān)重組蛋白:

產(chǎn)品名稱 貨號 靶點 來源 蛋白標(biāo)簽
Recombinant Human Single-stranded DNA cytosine deaminase (AICDA) CSB-BP001487HU AICDA Baculovirus N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Mouse Single-stranded DNA cytosine deaminase (Aicda) CSB-EP001487MO Aicda E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF) CSB-EP002655HU BDNF E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF), partial CSB-EP002655HU1 BDNF E.coli N-terminal GST-tagged
Recombinant Human Proepiregulin (EREG), partial CSB-EP007779HU EREG E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Oxytocin-neurophysin 1 (OXT), partial CSB-EP017315HU OxT E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Oxytocin-neurophysin 1 (OXT), partial CSB-EP017315HUb3 OXT E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Mouse Oxytocin-neurophysin 1 (Oxt), partial CSB-EP017315MO Oxt E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Oxytocin-neurophysin 1 (OXT), partial CSB-MP017315HU OXT Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human PRKCA-binding protein (PICK1), partial CSB-RP054454h PICK1 E.coli N-terminal GST-tagged
Recombinant Human Glutamyl aminopeptidase (ENPEP), partial CSB-RP147594h(c) ENPEP E.coli N-terminal 6xHis-tagged
Recombinant Rat Brain-derived neurotrophic factor (Bdnf), partial CSB-RP166394r Bdnf E.coli N-terminal 6xHis-tagged
Recombinant Human Oxytocin-neurophysin 1 (OXT), partial CSB-YP017315HU OXT Yeast N-terminal 6xHis-tagged
Recombinant Human Oxytocin-neurophysin 1 (OXT) CSB-YP017315HU(A4) OXT Yeast Tag-Free
Recombinant Human Oxytocin-neurophysin 1 (OXT) CSB-YP017315HU(A4)a4 OXT Yeast N-terminal 6xHis-sumostar-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF) CSB-EP002655HU(A4) BDNF E.coli N-terminal Myc-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF) CSB-EP002655HU(A4)h7 BDNF E.coli N-terminal 6xHis-Myc-tagged
Recombinant Mouse Single-stranded DNA cytosine deaminase (Aicda) CSB-YP001487MO Aicda Yeast N-terminal 10xHis-tagged
Recombinant Human Proepiregulin (EREG), partial (Active) CSB-AP002621HU EREG E.Coli Tag-Free
Recombinant Human Brain-derived neurotrophic factor (BDNF) (Active) CSB-AP003781HU BDNF E.coli Tag-Free
Recombinant Mouse Histone acetyltransferase p300 (Ep300), partial CSB-EP007702MO Ep300 E.coli C-terminal 6xHis-tagged
Recombinant Mouse Histone acetyltransferase p300 (Ep300), partial CSB-EP007702MOb1 Ep300 E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged

自閉癥研究相關(guān)抗體:

產(chǎn)品名稱 貨號 靶點 反應(yīng)種屬 應(yīng)用范圍
ABCB6 Antibody CSB-PA001052GA01HU ABCB6 Human, Mouse, Rat ELISA, WB
ABCB6 Antibody CSB-PA976738 ABCB6 Human, Mouse, Rat ELISA, WB, IHC
ABCB6 Antibody CSB-PA273896 ABCB6 Human, Mouse, Rat ELISA, WB
AICDA Antibody CSB-PA001487LA01HU AICDA Human, Mouse ELISA, WB
AICDA Antibody CSB-PA006133 AICDA Human, Mouse, Rat ELISA, WB
AICDA Antibody CSB-PA001487GA01HU AICDA Human, Mouse, Rat ELISA, WB
AICDA Antibody CSB-PA212701 AICDA Human, Mouse ELISA, IHC
ARSD Antibody CSB-PA010066 ARSD Human ELISA, IHC, IF
ARSD Antibody CSB-PA002144GA01HU ARSD Human ELISA, WB, IHC
ARSD Antibody CSB-PA215417 ARSD Human ELISA, IHC, IF
BDNF Antibody CSB-PA002655LA01HU BDNF Human ELISA, IHC
BDNF Antibody CSB-PA05775A0Rb BDNF Human, Mouse ELISA, WB, IHC
Bdnf Antibody CSB-PA16639A0Rb Bdnf Rat, Human ELISA, WB
BDNF Antibody CSB-PA002655GA01HU BDNF Human, Mouse, Rat ELISA
BDNF Antibody CSB-PA616184 BDNF Human, Mouse, Rat ELISA, WB, IHC
BDNF Antibody CSB-PA988388 BDNF Human, Mouse, Rat ELISA, IHC
BDNF Recombinant Monoclonal Antibody CSB-RA989910A0HU BDNF Human, Mouse ELISA, WB
ELK3 Antibody CSB-PA007606LA01HU ELK3 Human ELISA, IHC
Phospho-ELK3 (S357) Antibody CSB-PA008025 ELK3 Human, Mouse, Monkey ELISA, WB, IHC, IF
ELK3 Antibody CSB-PA008026 ELK3 Human, Mouse ELISA, IF