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BIRC5

BIRC5,即含桿狀病毒IAP重復(fù)序列蛋白5,是一種細(xì)胞凋亡抑制蛋白(IAPs)家族成員,主要通過(guò)抑制caspase激活來(lái)負(fù)向調(diào)節(jié)細(xì)胞凋亡或程序性細(xì)胞死亡。BIRC5在多種腫瘤中高度表達(dá),包括肺癌和肝癌,并與腫瘤干細(xì)胞(CSC)的調(diào)控、上皮間質(zhì)轉(zhuǎn)化(EMT)過(guò)程密切相關(guān)。其作用機(jī)制涉及到與多種信號(hào)通路的交互,例如Wnt/β-catenin信號(hào)通路,該通路在腫瘤發(fā)展、細(xì)胞增殖和凋亡中發(fā)揮關(guān)鍵作用。BIRC5的生物學(xué)意義在于其在細(xì)胞生存、腫瘤發(fā)展、DNA損傷修復(fù)中的作用,是腫瘤治療中的潛在靶點(diǎn),其表達(dá)水平的變化與多種腫瘤的預(yù)后密切相關(guān)。

熱銷產(chǎn)品

Recombinant Mouse Baculoviral IAP repeat-containing protein 5 (Birc5) (CSB-EP002706MOa0)

驗(yàn)證數(shù)據(jù)

CSB-EP002706MOa0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BIRC5 Recombinant Monoclonal Antibody (CSB-RA209144A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA209144A0HU

IHC image of CSB-RA209144A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

BIRC5 Antibodies

BIRC5 for Homo sapiens (Human)

BIRC5 for Mus musculus (Mouse)

BIRC5 for Human, Rat

BIRC5 Proteins

BIRC5 Proteins for Homo sapiens (Human)

BIRC5 Proteins for Mus musculus (Mouse)

BIRC5 Proteins for Pongo abelii (Sumatran orangutan)

BIRC5 Proteins for Felis catus (Cat) (Felis silvestris catus)

BIRC5 Proteins for Bos taurus (Bovine)

BIRC5 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

BIRC5 Proteins for Rattus norvegicus (Rat)

BIRC5 Proteins for Sus scrofa (Pig)