CD7

CD7分子是一個含有40 kDa的單鏈糖蛋白分子，屬于免疫球蛋白超家族。CD7分子是人體免疫細(xì)胞膜上一類重要的表面標(biāo)志物，在淋巴細(xì)胞發(fā)育成熟過程中發(fā)揮協(xié)同刺激分子受體的作用。作為T細(xì)胞表面的高特異性靶點(diǎn)，CD7與大多數(shù)T細(xì)胞血液腫瘤的發(fā)生和發(fā)展息息相關(guān)，包括幼稚T細(xì)胞腫瘤（T-ALL/LBL/NKT細(xì)胞白血病）和成熟T細(xì)胞腫瘤（外周T細(xì)胞淋巴瘤、NKT細(xì)胞淋巴瘤、間變大細(xì)胞淋巴瘤）。CD7和抗體或者抗體衍生物結(jié)合后會迅速內(nèi)化，這使得針對CD7分子的抗體非常適合作用藥物運(yùn)輸工具。CD7分子被認(rèn)為與疾病侵襲性、耐藥性及不良預(yù)后密切相關(guān)。目前，CD7分子作為靶向抗腫瘤治療的新靶點(diǎn)，將為CD7＋復(fù)發(fā)/難治性血液系統(tǒng)惡性疾病治療提供新的研究方向。

Recombinant Human CD7 活性蛋白實(shí)驗驗證數(shù)據(jù)

High Purity Validated by
SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD7 at 5 μg/ml can bind SECTM1 (CSB-MP819898HU), the EC₅₀ is 1.236-1.773 ng/ml.

Excellent Bioactivity Validated by LSPR Assay

Human CD7 protein hFc and Myc tag (CSB-MP004953HU) captured on COOH chip can bind Human SECTM1 protein hFc tag (CSB-MP819898HU) with an affinity constant of 1.84 nM as detected by LSPR Assay.