CLDN6
CLDN6位于染色體16p3.3,分子量大約20-40kDa。Claudins成員之間具有相似的結(jié)構(gòu),每個Claudin分子有4個跨膜結(jié)構(gòu)域,2個細胞外環(huán)和2條胞內(nèi)尾區(qū)。CLDN6擁有一個C端的PDZ結(jié)合位點,使得緊密連接蛋白能與細胞內(nèi)某些蛋白發(fā)生相互作用關(guān)系,在細胞連接及上皮組織通透性等方面均可發(fā)揮重要作用
越來越多的研究表明,CLDN6異常表達可參與乳腺癌,卵巢癌,宮頸癌,胃癌,肺癌等多種惡性腫瘤發(fā)生及發(fā)展過程。CLDN6作為細胞骨架的形成和細胞信號通路調(diào)節(jié)的重要分子,可影響細胞的生長進程,這為腫瘤的診斷和干預(yù)提供了新的方向。目前,多款針對CLDN6的藥物已處于臨床和臨床前階段,用于多種腫瘤的治療。
CUSABIO-哺乳包膜VIPs平臺成功開發(fā)CLDN6全長跨膜蛋白(4次跨膜),展示了完整生物活性。
熱銷產(chǎn)品
● Recombinant Human Claudin-6(CLDN6)-VLPs (Active) (CSB-MP005508HU(A4))
CSB-MP005508HU(A4) is detected by Mouse anti-6*His monoclonal antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC50 is 1.501-2.035 ng/mL
The presence of VLP-like structures was confirmed by TEM
● CLDN6/9 Recombinant Monoclonal Antibody CSB-RA005508MA1HU
The Binding Activity of Huamn CLDN6 with Anti-CLDN6/9 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 1.501-2.035 ng/mL.
The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 24.93-35.47 ng/mL.
Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 recombinant antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
CLDN6 Antibodies
CLDN6 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA207788 | Phospho-CLDN6 (Tyr219) Antibody | Human,Mouse | ELISA,WB |
CSB-PA263732 | CLDN6 Antibody | Human | ELISA,WB,IHC,IF |
CSB-PA001673 | CLDN6 Antibody | Human | WB, IHC, IF, ELISA |
CSB-PA070220 | Phospho-CLDN6 (Y219) Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA070221 | CLDN6 Antibody | Human,Mouse | IHC, ELISA |
CSB-PA005508LA01HU | CLDN6 Antibody | Human | ELISA, IHC, IF |
CSB-PA005508LB01HU | CLDN6 Antibody, HRP conjugated | Human | ELISA |
CSB-RA005508MA1HU | CLDN6/9 Monoclonal Antibody | Human | ELISA, FC |
CLDN6 Proteins
CLDN6 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP005508HU1 CSB-EP005508HU1 CSB-BP005508HU1 CSB-MP005508HU1 CSB-EP005508HU1-B |
Recombinant Human Claudin-6 (CLDN6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP005508HU(A4) | Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) | Mammalian cell |
CLDN6 Proteins for Homo sapiens(Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-CF005508HU | Recombinant Human Claudin-6 (CLDN6), partial | in vitro E.coli expression system |