GPX4
GPX4的中文全稱為谷胱甘肽過氧化物酶4,也被稱為磷脂過氧化氫谷胱甘肽過氧化物酶(PHGPx)。它主要來源于生物體內(nèi),是含硒GPX家族的第四位成員。GPX4的作用機制在于利用其催化活性,削弱脂質(zhì)過氧化物的毒性,從而維持膜脂質(zhì)雙分子層的穩(wěn)態(tài),防止細胞發(fā)生鐵死亡。在生物學上,GPX4作為鐵死亡的關(guān)鍵調(diào)控因子,對于細胞的存活和穩(wěn)態(tài)具有重要意義。此外,GPX4在腫瘤組織中的表達水平明顯升高,可能作為癌基因參與腫瘤的發(fā)生和發(fā)展,同時也是癌癥免疫治療的新調(diào)控因子,具有潛在的治療價值。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
GPX4 Recombinant Monoclonal Antibody (CSB-RA188594A0HU)
驗證數(shù)據(jù)
IHC image of CSB-RA188594A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
GPX4 Antibodies
GPX4 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA009869GA01HU | GPX4 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA03049A0Rb | GPX4 Antibody | Human, Mouse, Rat | ELISA, IHC, IF |
CSB-PA03049B0Rb | GPX4 Antibody, HRP conjugated | Human | ELISA |
CSB-PA03049C0Rb | GPX4 Antibody, FITC conjugated | Human | |
CSB-PA03049D0Rb | GPX4 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA188594A0HU | GPX4 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
GPX4 Proteins
GPX4 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-BP009869HU CSB-MP009869HU CSB-EP009869HU-B |
Recombinant Human Phospholipid hydroperoxide glutathione peroxidase (GPX4) (U73S), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP009869HU | Recombinant Human Phospholipid hydroperoxide glutathione peroxidase (GPX4) (U73S), partial | E.coli |
CSB-YP009869HU | Recombinant Human Phospholipid hydroperoxide glutathione peroxidase (GPX4) (U73S), partial | Yeast |
GPX4 ELISA Kit
GPX4 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL009869HU | Human Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(GPX4) ELISA kit | serum, plasma, tissue homogenates | 1.95 μU/mL |