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PPARGC1A

PPARGC1A,即過氧化物酶體增殖物激活受體γ共激活劑1α,別名PGC-1α、PPRC1α。它是一種轉錄共激活因子,主要在心臟、骨骼肌、肝臟和腎臟等組織中高表達,而在大腦和胰腺中表達水平較低,在腸道和白色脂肪組織中表達水平非常低。PPARGC1A的作用機制涉及與多種核受體和轉錄因子相互作用,增強其轉錄活性,調節(jié)線粒體生物發(fā)生、能量代謝和熱生成等過程。它參與晝夜節(jié)律和能量代謝的整合,激活與代謝相關的基因,如PDK4和PEPCK,調控生物鐘基因的振蕩表達。PPARGC1A是適應性產(chǎn)熱和代謝重編程的關鍵調控因子,其表達水平受長期能量供應的控制,且在肥胖和高脂飲食環(huán)境下表達水平下降。PPARGC1A的功能異常與多種代謝性疾病有關,是治療II型糖尿病、肥胖癥、心肌病等代謝紊亂的潛在靶點。

熱銷產(chǎn)品

Recombinant Human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) (CSB-EP871382HUa0)

驗證數(shù)據(jù)

CSB-EP871382HUa0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human peroxisome proliferative activated receptor gama coactivator 1 alpha,PPARGC1 ELISA Kit (CSB-E11761h)

驗證數(shù)據(jù)

CSB-E11761h 標準曲線

貨號:CSB-E11761h

規(guī)格:96T/48T

靈敏度:31.25 pg/mL

檢測范圍:125 pg/mL-8000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PPARGC1A Antibodies

PPARGC1A for Homo sapiens (Human)

PPARGC1A Proteins

PPARGC1A Proteins for Mus musculus (Mouse)

PPARGC1A Proteins for Bos taurus (Bovine)

PPARGC1A Proteins for Sus scrofa (Pig)

PPARGC1A Proteins for Homo sapiens (Human)

PPARGC1A Proteins for Rattus norvegicus (Rat)

PPARGC1A ELISA Kit

PPARGC1A ELISA Kit for Homo sapiens (Human)

PPARGC1A ELISA Kit for Mus musculus (Mouse)