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UBA3

NEDD8-activating enzyme E1 catalytic subunit is a protein in humans that is encoded by UBA3 gene. Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

UBA3 Antibodies

UBA3 for Homo sapiens (Human)

UBA3 Proteins

UBA3 Proteins for Triticum aestivum (Wheat)

UBA3 Proteins for Dictyostelium discoideum (Slime mold)

UBA3 Proteins for Pongo abelii (Sumatran orangutan)

UBA3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

UBA3 Proteins for Mus musculus (Mouse)

UBA3 Proteins for Homo sapiens (Human)

UBA3 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

UBA3 Proteins for Rattus norvegicus (Rat)

UBA3 Proteins for Drosophila melanogaster (Fruit fly)