ULBP1

UL16結(jié)合蛋白-1（UL16-binding protein 1，ULBP1）又稱NKG2DL，屬于ULBPs家族的成員，是NKG2D的配體之一。而NKG2D是免疫效應(yīng)細胞上表達的一種活化性受體，能夠識別不同的MHC-I類相關(guān)分子MHCA、MHCB和另一類MHC-I類相關(guān)分子ULBPs，這些配體在正常細胞中不常見，在病毒感染、腫瘤惡性轉(zhuǎn)化等條件下誘導(dǎo)表達。ULBP1配體可激活自然殺傷細胞（NK）和CD8+T細胞的NKG2D受體，從而觸發(fā)免疫殺傷。研究人員發(fā)現(xiàn)，ULBP1在子癇前期（PE）患者外周血外泌體中的高表達，可能會為PE的診治提供一定依據(jù)。此外，有關(guān)實驗數(shù)據(jù)表明ULBP1在人類肝細胞癌（HCC）中大量表達。且NKG2D受體和ULBP1的表達與HCC炎性細胞的存在密切相關(guān)。另有研究提示，肝切除術(shù)后的早期復(fù)發(fā)與ULBP1的表達缺失密切相關(guān)。因此，ULBP1有望成為HCC免疫治療的分子靶點。

Recombinant Human ULBP1 活性蛋白實驗驗證數(shù)據(jù)

High Purity Validated
by SDS-PAGE

CSB-MP015007HU is detected by Mouse anti-6*His monoclonal antibody.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized KLRK1 (CSB-MP012474HU1) at 10 μg/ml can bind human ULBP1, the EC₅₀ of human ULBP1 protein is 228.5-427.6 ng/ml.

Excellent Bioactivity Validated by LSPR Assay

Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.