自2008年起，國際甲狀腺聯(lián)盟（ITF）將每年的5月25日定為世界甲狀腺日（World Thyroid Day），該節(jié)日所在的一周為“國際甲狀腺知識宣傳周”，旨在提升公眾對甲狀腺健康重要性的認識，并促進全球范圍內(nèi)對甲狀腺疾病的研究與防治。2024年的主題為“甲狀腺疾病是非傳染性疾病”。
甲狀腺，這個位于頸部前方的微小蝴蝶狀腺體，雖然體積不大，對于調(diào)節(jié)人體新陳代謝速率、影響生長發(fā)育乃至情緒平衡至關重要，其分泌的甲狀腺激素（T3與T4）觸及全身每個細胞，確保能量的有效利用。
甲狀腺疾病是一系列影響甲狀腺功能的病癥，大致可分為兩大類：一類是甲狀腺激素產(chǎn)生過多或過少導致的功能性異常，另一類是甲狀腺結構本身的改變，如結節(jié)或腫瘤。
探究這些疾病的根源，科學家們發(fā)現(xiàn)其發(fā)病機制錯綜復雜，涉及遺傳因素、環(huán)境條件與自身免疫反應的相互作用。例如，Graves?。ǘ拘詮浡约谞钕倌[）中，免疫系統(tǒng)錯誤攻擊甲狀腺，引發(fā)過度活躍；相反地，橋本甲狀腺炎則是甲狀腺遭受自身免疫系統(tǒng)破壞，導致激素生產(chǎn)不足。此外，碘攝入不當與特定化學物質暴露亦被視為風險因素之一。
近年來，甲狀腺疾病治療藥物的研發(fā)聚焦于針對性更強、副作用更小的新型藥物開發(fā)，特別是針對自身免疫性甲狀腺疾病和甲狀腺癌的創(chuàng)新療法。比如，針對Graves病中TSH受體抗體的新型拮抗劑開發(fā)，以精準阻斷過度活躍的甲狀腺刺激；甲狀腺眼病領域，Tepezza的成功引入為通過抑制IGF-1R緩解癥狀樹立了新標桿，并激勵了對更多創(chuàng)新靶點的探索。此外，研究還著重于探索甲狀腺癌的靶向治療，如針對VEGFR、BRAF突變的酪氨酸激酶抑制劑。
華美生物長期致力于為科研工作者提供高質量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品，鑒于甲狀腺疾病研究的重要性與迫切性，在此特別整理了一系列與甲狀腺疾病研究相關的20余種熱門靶點及相關試劑產(chǎn)品列舉如下，供您選擇：
甲狀腺研究相關ELISA試劑盒：
| 產(chǎn)品名稱 | 貨號 | 靶點 | 檢測范圍 | 靈敏度 |
|---|---|---|---|---|
| Human Serine/threonine-protein kinase B-raf(BRAF) ELISA kit | CSB-EL002791HU | BRAF | 31.25 pg/mL-2000 pg/mL | 7.8 pg/mL |
| Mouse C-Reactive Protein,CRP ELISA Kit | CSB-E07923m(1) | CRP | 5 ng/mL-4000 ng/mL | 5 ng/mL |
| Rabbit C-Reactive Protein,CRP ELISA Kit | CSB-E06847Rb | CRP | 7.8 pg/mL-2000 pg/mL | 2 pg/mL |
| Rat C-Reactive Protein,CRP ELISA Kit | CSB-E07922r | CRP | 31.25 ng/mL-2000 ng/mL | 7.81 ng/mL |
| Mouse C-Reactive Protein,CRP ELISA Kit | CSB-E07923m | CRP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
| Pig C-reactive protein,CRP ELISA Kit | CSB-E08163p | CRP | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
| Bovine C-reactive protein,CRP ELISA Kit | CSB-E08577b | CRP | 1.25 ng/mL-80 ng/mL | 1.25 ng/mL |
| Canine C-Reactive Protein,CRP ELISA Kit | CSB-E14262c | CRP | 0.312 μg/mL-20 μg/mL | 0.078 μg/mL |
| Sheep C-reactive protein(CRP) ELISA Kit | CSB-E15081Sh | CRP | 0.625 μg/mL-40 μg/mL | 0.156 μg/mL |
| Hamster C-reactive protein(CRP) ELISA Kit | CSB-EL005991HA | CRP | 12.5 ng/mL-800 ng/mL | 3.12 ng/mL |
| Human Catenin beta-1 (CTNNB1/CTNNB/OK/SW-cl.35/PRO2286) ELISA kit | CSB-E08963h | CTNNB1 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
| Mouse β-catenin,β-cat ELISA Kit | CSB-E11307m | CTNNB1 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
| Human epidermal growth factor receptor,EGFR ELISA Kit | CSB-E12124h | EGFR | 0.312 ng/mL-20 ng/mL | 0.019 ng/mL |
| Mouse Insulin-like growth factor 1,IGF-1 ELISA Kit | CSB-E04581m | IGF1 | 0.156 ng/mL-10 ng/mL | 0.151 ng/mL |
| Rat Insulin-like growth factor 1,IGF-1 ELISA Kit | CSB-E04582r | IGF1 | 0.156 ng/mL-10 ng/mL | 0.151 ng/mL |
| Pig insulin-like growth factors-1,IGF-1 ELISA Kit | CSB-E06829p | IGF1 | 6.25 ng/mL-400 ng/mL | 1.56 ng/mL |
| Rabbit Insulin-like growth factor 1,IGF-1 ELISA Kit | CSB-E06994Rb | IGF1 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
| Bovine Insulin-like growth factor 1,IGF-1 ELISA Kit | CSB-E08893b | IGF1 | 0.75 ng/mL-60 ng/mL | 0.94 ng/mL |
| Chicken Insulin-like growth factors 1,IGF-1 ELISA Kit | CSB-E09867Ch | IGF1 | 125 pg/mL-2000 pg/mL | 125 pg/mL |
| Sheep insulin-like growth factor 1,IGF-1 ELISA Kit | CSB-E13753Sh | IGF1 | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
甲狀腺研究相關重組蛋白：
| 產(chǎn)品名稱 | 貨號 | 靶點 | 來源 | 蛋白標簽 |
|---|---|---|---|---|
| Recombinant Mouse Thyrotropin receptor (Tshr), partial | CSB-BP025131MO | Tshr | Baculovirus | N-terminal 6xHis-tagged |
| Recombinant Marmota monax Tumor necrosis factor (TNF), partial | CSB-BP523593MQG | TNF | Baculovirus | N-terminal 10xHis-tagged |
| Recombinant Human Catenin beta-1 (CTNNB1) | CSB-EP006169HU | CTNNB1 | E.coli | N-terminal GST-tagged |
| Recombinant Human Epidermal growth factor receptor (EGFR), partial | CSB-EP007479HU3 | EGFR | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
| Recombinant Human Interleukin-6 (IL6) | CSB-EP011664HU | IL6 | E.coli | N-terminal 6xHis-tagged |
| Recombinant Sheep Interleukin-6 (IL6) | CSB-EP011664SH | IL6 | E.coli | N-terminal GST-tagged |
| Recombinant Human GTPase KRas (KRAS), partial | CSB-EP012493HU1 | KRAS | E.coli | N-terminal 6xHis-tagged |
| Recombinant Human Homeobox protein Nkx-2.1 (NKX2-1) | CSB-EP015841HU | NKX2-1 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Human Paired box protein Pax-8 (PAX8) | CSB-EP017494HU | PAX8 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Human Telomerase reverse transcriptase (TERT), partial | CSB-EP023391HU | TERT | E.coli | N-terminal 6xHis-tagged |
| Recombinant Mouse Telomerase reverse transcriptase (Tert), partial | CSB-EP023391MO | Tert | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Rat Thyroglobulin (Tg), partial | CSB-EP023442RA | Tg | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Bovie Tumor necrosis factor (TNF), partial | CSB-EP023955BO | TNF | E.coli | N-terminal 6xHis-tagged |
| Recombinant Bovie Tumor necrosis factor (TNF), partial | CSB-EP023955BOe0 | TNF | E.coli | N-terminal GST-tagged |
| Recombinant Human Tumor necrosis factor (TNF), partial | CSB-EP023955HU | TNF | E.coli | N-terminal 6xHis-tagged |
| Recombinant Mouse Tumor necrosis factor (Tnf), partial | CSB-EP023955MO1 | Tnf | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Sheep Tumor necrosis factor (TNF), partial | CSB-EP023955SH | TNF | E.coli | N-terminal GST-tagged |
| Recombinant Human Cellular tumor antigen p53 (TP53) | CSB-EP024077HU | TP53 | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Mouse Cellular tumor antigen p53 (Tp53) | CSB-EP024077MO | Tp53 | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Pig Vascular endothelial growth factor A (VEGFA) | CSB-EP025833PI | VEGFA | E.coli | N-terminal 6xHis-tagged |
甲狀腺研究相關抗體：
● 重組抗體：
| 產(chǎn)品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
|---|---|---|---|---|
| Phospho-BRAF (T401) Recombinant Monoclonal Antibody | CSB-RA002791A401phHU | BRAF | Human | ELISA, WB, IF |
| BRAF Recombinant Monoclonal Antibody | CSB-RA171021A0HU | BRAF | Human | ELISA, IHC |
| CRP Recombinant Monoclonal Antibody | CSB-RA988767A0HU | CRP | Human | ELISA, IHC |
| Phospho-CTNNB1 (S33/S37) Recombinant Monoclonal Antibody | CSB-RA006169A33phHU | CTNNB1 | Human | ELISA, IF |
| CTNNB1 Recombinant Monoclonal Antibody | CSB-RA155605A0HU | CTNNB1 | Human | ELISA, IHC |
| CTNNB1 Recombinant Monoclonal Antibody | CSB-RA006169MA1HU | CTNNB1 | Human | ELISA, IHC, IF, FC |
| Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
| Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
| IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | IL6 | Human | ELISA |
| INS Recombinant Monoclonal Antibody | CSB-RA584163A0HU | INS | Human | ELISA, IHC |
| Phospho-MTOR (S2481) Recombinant Monoclonal Antibody | CSB-RA008968A2481phHU | MTOR | Human | ELISA, WB, IF |
| Phospho-MTOR (S2448) Recombinant Monoclonal Antibody | CSB-RA008968A2448phHU | MTOR | Human | ELISA, WB, IHC, IF |
| NKX2-1 Recombinant Monoclonal Antibody | CSB-RA181189A0HU | NKX2-1 | Human | ELISA, WB, IHC, FC |
| PAX8 Recombinant Monoclonal Antibody | CSB-RA248028A0HU | PAX8 | Human | ELISA, IHC |
| Phospho-PTEN (S380) Recombinant Monoclonal Antibody | CSB-RA018964A380phHU | PTEN | Human | ELISA, WB |
| RET Recombinant Monoclonal Antibody | CSB-RA288083A0HU | RET | Human | ELISA, FC |
| TERT Recombinant Monoclonal Antibody | CSB-RA798840A0HU | TERT | Human | ELISA, IHC |
● 單克隆抗體：
| 產(chǎn)品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
|---|---|---|---|---|
| CRP Monoclonal Antibody | CSB-MA027411E0m | CRP | Human | ELISA, IHC |
| CTNNB1 Monoclonal Antibody | CSB-MA000223 | CTNNB1 | Human,Mouse,Rat | ELISA, WB, IHC |
| CTNNB1 Monoclonal Antibody | CSB-MA080197 | CTNNB1 | Human,Mouse,Rat | ELISA, WB, IHC |
| CTNNB1 Monoclonal Antibody | CSB-MA922448 | CTNNB1 | Human,Mouse,Rat | ELISA, WB, IHC |
| CTNNB1 Monoclonal Antibody | CSB-MA907551 | CTNNB1 | Human | ELISA, IHC |
| EGFR Monoclonal Antibody | CSB-MA000199 | EGFR | Human | ELISA, WB, IHC, IF |
| EGFR Monoclonal Antibody | CSB-MA000293 | EGFR | Human | ELISA, WB |
| IL6 Monoclonal Antibody | CSB-MA067571A0m | IL6 | Human | ELISA, WB, IHC |
| PTH Monoclonal Antibody | CSB-MA0189871A0m | PTH | Human | ELISA |
| TNF Monoclonal Antibody | CSB-MA084771A0m | TNF | Bovine | ELISA |
| TNF Monoclonal Antibody | CSB-MA080271 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
| TNF Monoclonal Antibody | CSB-MA080272 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
| TP53 Monoclonal Antibody | CSB-MA0240771A0m | TP53 | Human | ELISA, WB, IHC |
| TP53 Monoclonal Antibody | CSB-MA000208 | TP53 | Human | ELISA, WB, IHC, IF |
| TP53 Monoclonal Antibody | CSB-MA989534 | TP53 | Human | ELISA, WB |
| TP53 Monoclonal Antibody | CSB-MA189580 | TP53 | Human,Dog,Mouse,Rat | ELISA, WB |
● 多克隆抗體：
| 產(chǎn)品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
|---|---|---|---|---|
| BRAF Antibody | CSB-PA002791LA01HU | BRAF | Human | ELISA, IHC, IF |
| BRAF Antibody | CSB-PA003928 | BRAF | Human, Mouse, Rat | ELISA, WB, IHC |
| BRAF Antibody | CSB-PA003929 | BRAF | Human, Mouse | ELISA, WB, IHC, IF |
| Phospho-BRAF (S602) Antibody | CSB-PA050147 | BRAF | Human, Mouse, Rat | ELISA, WB, IHC |
| Phospho-BRAF (T753) Antibody | CSB-PA050146 | BRAF | Human, Mouse, Rat | ELISA, WB |
| Phospho-BRAF (T599) Antibody | CSB-PA050149 | BRAF | Human, Mouse, Rat | ELISA, IHC |
| BRAF Antibody | CSB-PA050150 | BRAF | Human, Mouse, Rat | ELISA, WB |
| BRAF Antibody | CSB-PA050151 | BRAF | Human, Mouse, Rat | ELISA, IHC |
| Phospho-BRAF (S446) Antibody | CSB-PA050148 | BRAF | Human, Mouse | ELISA, WB, IHC |
| BRAF Antibody | CSB-PA050152 | BRAF | Human, Mouse | ELISA, WB, IHC |
| BRAF Antibody | CSB-PA587286 | BRAF | Human, Mouse | ELISA, WB, IHC |
| BRAF Antibody | CSB-PA163656 | BRAF | Human, Mouse | ELISA, WB, IHC |
| BRAF Antibody | CSB-PA179620 | BRAF | Human, Mouse | ELISA, WB, IHC |
| BRAF (Ab-753) Antibody | CSB-PA921529 | BRAF | Human, Mouse | ELISA, WB |
| BRAF (Ab-446) Antibody | CSB-PA134950 | BRAF | Human, Mouse | ELISA, WB, IHC |
| Phospho-BRAF (Ser446) Antibody | CSB-PA575128 | BRAF | Human, Mouse | ELISA, WB |
| Phospho-BRAF (Thr753) Antibody | CSB-PA985068 | BRAF | Human, Mouse, Rat | ELISA, WB |
| Phospho-BRAF (Thr599) Antibody | CSB-PA243682 | BRAF | Human, Mouse, Rat | ELISA, IHC |
| CCDC6 Antibody | CSB-PA623068LA01HU | CCDC6 | Human | ELISA, WB, IHC, IF |
| CRP Antibody | CSB-PA06079A0Rb | CRP | Human | ELISA, WB, IHC |
