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2024年世界防治結(jié)核病日:
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防治結(jié)核病

每年3月24日是世界防治結(jié)核病日,這是為了紀(jì)念1882年德國微生物學(xué)家羅伯特·科霍對結(jié)核病病原菌的發(fā)現(xiàn)。世界衛(wèi)生組織于1993年在英國倫敦召開的第46屆世界衛(wèi)生大會(huì)通過了“全球結(jié)核病緊急狀態(tài)宣言”,并積極宣傳此病的防治的重要。1995年底,世界衛(wèi)生組織將每年3月24日定為世界防治結(jié)核病日,以此提醒公眾加深對結(jié)核病的認(rèn)識。

結(jié)核病,俗稱“癆病”,是由結(jié)核分枝桿菌引起的一種慢性傳染病。結(jié)核桿菌主要通過空氣傳播,當(dāng)患有肺結(jié)核的病人咳嗽、打噴嚏或說話時(shí),結(jié)核桿菌會(huì)隨著飛沫排出,進(jìn)入空氣中,被他人吸入后可能感染。結(jié)核病可侵犯人體全身各種器官,但以引起肺結(jié)核最為多見。在全球范圍內(nèi),肺結(jié)核是導(dǎo)致死亡的主要傳染病之一。

目前,結(jié)核病研究方向主要集中于其生物學(xué)特性與致病機(jī)制、抗結(jié)核藥物與疫苗研發(fā)、宿主免疫應(yīng)答與調(diào)控、結(jié)核病診斷技術(shù)的改進(jìn)、結(jié)核病流行病學(xué)與防控策略、結(jié)核病與其他疾病的相互關(guān)系等方面。結(jié)核病研究相關(guān)的靶點(diǎn)主要包括針對結(jié)核分枝桿菌(MTB)本身的靶點(diǎn)以及針對宿主免疫反應(yīng)的靶點(diǎn):

首先,針對結(jié)核分枝桿菌本身的靶點(diǎn),研究者們一直在尋找能夠有效抑制或殺死結(jié)核桿菌的藥物作用點(diǎn)。這包括結(jié)核桿菌的代謝途徑、細(xì)胞壁合成、DNA復(fù)制和轉(zhuǎn)錄等關(guān)鍵過程。例如,近年來發(fā)現(xiàn)的DarT和DarG酶系統(tǒng),它們可逆地修改染色體DNA,控制細(xì)菌復(fù)制,為新型抗結(jié)核抗生素的開發(fā)提供了新的思路。

其次,針對宿主免疫反應(yīng)的靶點(diǎn)也是結(jié)核病研究的重要方向。結(jié)核病的發(fā)病過程中,宿主免疫反應(yīng)起著至關(guān)重要的作用。研究者們正在尋找能夠調(diào)節(jié)或增強(qiáng)宿主免疫反應(yīng)的藥物或方法,以更有效地控制結(jié)核病。例如,漿細(xì)胞樣樹突狀細(xì)胞(plasmacytoid dendritic cells)在結(jié)核病免疫反應(yīng)中發(fā)揮著重要作用,其過度產(chǎn)生的I型干擾素與疾病進(jìn)展相關(guān),因此,調(diào)節(jié)這類細(xì)胞的反應(yīng)可能是一個(gè)潛在的治療靶點(diǎn)。

此外,隨著對結(jié)核病發(fā)病機(jī)制的深入理解,研究者們還發(fā)現(xiàn)了其他可能的靶點(diǎn),如與結(jié)核病發(fā)病相關(guān)的基因、蛋白質(zhì)或信號通路等。這些靶點(diǎn)的發(fā)現(xiàn)為結(jié)核病的治療和預(yù)防提供了新的可能性。

華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品。特整理了結(jié)核病研究相關(guān)的20個(gè)熱門研究靶點(diǎn)及相關(guān)試劑產(chǎn)品列舉如下,供您選擇:

ELISA

● 結(jié)核桿菌抗體ELISA試劑盒

產(chǎn)品名稱 貨號 靶點(diǎn) 檢測范圍 靈敏度
牛結(jié)核桿菌抗體(IgG)酶聯(lián)免疫試劑盒 CSB-E17362B MTB Ab (IgG) / /
人結(jié)核桿菌(TB)抗體( IgG)酶聯(lián)免疫試劑盒 CSB-E04997h TB Ab (IgG) / /
人結(jié)核菌桿抗體IgM(TB-Ab IgM)酶聯(lián)免疫試劑盒 CSB-EQ027186HU TB Ab (IgM) / /

● 結(jié)核桿菌研究熱門靶點(diǎn)ELISA試劑盒

產(chǎn)品名稱 貨號 靶點(diǎn) 檢測范圍 靈敏度
牛白蛋白(ALB)酶聯(lián)免疫試劑盒 CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
小鼠白蛋白酶聯(lián)免疫試劑盒 CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
犬白蛋白(Alb)酶聯(lián)免疫試劑盒 CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
綿羊白蛋白酶聯(lián)免疫試劑盒 CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
馬白蛋白酶聯(lián)免疫試劑盒 CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
豬白蛋白酶聯(lián)免疫試劑盒 CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
山羊白蛋白(Alb)酶聯(lián)免疫試劑盒 CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
豚鼠白蛋白(ALB)酶聯(lián)免疫試劑盒 CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
兔白蛋白酶聯(lián)免疫試劑盒 CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
人CD4分子(CD4)酶聯(lián)免疫試劑盒 CSB-E08956h CD4 0.625 ng/mL-40 ng/mL 0.156 ng/mL
大鼠CD4分子(CD4)酶聯(lián)免疫試劑盒 CSB-E12928r CD4 0.78 U/mL-50 U/mL 0.195 U/mL
雞CD4分子(CD4)酶聯(lián)免疫試劑盒 CSB-E13114C CD4 3.125 ng/mL-800 ng/mL 3.125 ng/mL
人CD8分子(CD8)酶聯(lián)免疫試劑盒 CSB-E12707h CD8A 62.5 U/mL-4000 U/mL 15.6 U/mL
小鼠C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒 CSB-E07923m(1) CRP 5 ng/mL-4000 ng/mL 5 ng/mL
兔子C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒 CSB-E06847Rb CRP 7.8 pg/mL-2000 pg/mL 2 pg/mL
大鼠C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒 CSB-E07922r CRP 31.25 ng/mL-2000 ng/mL 7.81 ng/mL
小鼠C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒 CSB-E07923m CRP 15.6 ng/mL-1000 ng/mL 3.9 ng/mL
豬C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒 CSB-E08163p CRP 0.625 ng/mL-40 ng/mL 0.156 ng/mL
牛C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒 CSB-E08577b CRP 1.25 ng/mL-80 ng/mL 1.25 ng/mL
犬C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒 CSB-E14262c CRP 0.312 μg/mL-20 μg/mL 0.078 μg/mL

重組蛋白

● 結(jié)核桿菌重組蛋白:

產(chǎn)品名稱 貨號 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Mycobacterium tuberculosis Adenylate kinase (adk) CSB-EP404243MON adk E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Mycobacterium tuberculosis Putative amidase AmiB2 (amiB2) CSB-EP351872MVZ amiB2 E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Mycobacterium tuberculosis PeptiDoglycan-binding protein ArfA (arfA) CSB-YP353360MVZ arfA Yeast N-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase (cyp125) CSB-EP351308MVZ cyp125 E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase (cyp125) CSB-YP351308MVZ cyp125 Yeast N-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase (cyp125) CSB-EP351308MVZb0 cyp125 E.coli N-terminal 10xHis-tagged
Recombinant Mycobacterium tuberculosis Lanosterol 14-alpha demethylase (cyp51) CSB-BP006459MVZ cyp51 Baculovirus N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Mycobacterium tuberculosis Lanosterol 14-alpha demethylase (cyp51) CSB-EP006459MVZ cyp51 E.coli N-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis Lanosterol 14-alpha demethylase (cyp51) CSB-YP006459MVZa1 cyp51 Yeast N-terminal?6xHis-tagged and C-terminal Myc-tagged
Recombinant Mycobacterium paratuberculosis DNA integrity scanning protein DisA (disA) CSB-EP762077MLA disA E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Mycobacterium tuberculosis 6KDA early secretory antigenic target (esxA), partial CSB-YP358627MVZ esxA Yeast N-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis 6 kDa early secretory antigenic target (esxA), partial CSB-EP358627MVZ esxA E.coli C-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB) CSB-EP363658MVZ esxB E.coli N-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB) CSB-EP363658MVZb2 esxB E.coli N-terminal 10xHis-SUMO-tagged
Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB (esxB) CSB-YP363658MVZ esxB Yeast N-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH (esxH), partial CSB-EP363659MVZ esxH E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Mycobacterium tuberculosis Diacylglycerol acyltransferase/mycolyltransferase Ag85A (fbpA) CSB-EP358584MVZ fbpA E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Mycobacterium tuberculosis Diacylglycerol acyltransferase/mycolyltransferase Ag85A (fbpA), partial CSB-RP182794BA fbpA E.coli N-terminal 6xHis-tagged
Recombinant Mycobacterium tuberculosis Diacylglycerol acyltransferase/mycolyltransferase Ag85B (fbpB) CSB-EP314366MVZ fbpB E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Mycobacterium tuberculosis Diacylglycerol acyltransferase/mycolyltransferase Ag85B (fbpB) CSB-EP314366MVZa0 fbpB E.coli N-terminal 6xHis-tagged

● 結(jié)核桿菌研究熱門靶點(diǎn)蛋白:

產(chǎn)品名稱 貨號 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Bovine Serum albumin (ALB) CSB-YP001561BO ALB Yeast C-terminal 6xHis-Myc-tagged
Recombinant Bos taurus Albumin (ALB) CSB-BP001561BO ALB Baculovirus C-terminal 6xHis-tagged
Recombinant Chicken Serum albumin (ALB), partial CSB-YP001561CH ALB Yeast C-terminal 6xHis-tagged
Recombinant Mouse Serum albumin (Alb) CSB-BP001561MO Alb Baculovirus C-terminal 9xHis-tagged
Recombinant Chicken Albumin (ALB), partial CSB-EP001561CH ALB E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Macaca fascicularis albumin (ALB) CSB-MP001561MOV ALB Mammalian cell N-terminal 6xHis-Myc-tagged
Recombinant Macaca fascicularis albumin (ALB) CSB-EP001561MOV ALB E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Dog Serum albumin (ALB) CSB-EP001561DO ALB E.coli N-terminal 6xHis-tagged
Recombinant Dog Serum albumin (ALB) CSB-YP001561DO ALB Yeast N-terminal 6xHis-tagged
Recombinant Mouse Albumin (Alb) CSB-YP001561MO Alb Yeast N-terminal 6xHis-tagged
Recombinant Macaca fascicularis albumin (ALB) CSB-YP001561MOV ALB Yeast N-terminal 6xHis-tagged
Recombinant Rat Serum albumin (Alb) CSB-EP001561RA Alb E.coli N-terminal 6xHis-tagged and C-terminal Avi-tagged
Recombinant Rat Serum albumin (Alb), Biotinylated CSB-EP001561RA-B Alb E.coli N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged
Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial CSB-CF004935HU1 CD4 in vitro E.coli expression system N-terminal 6xHis-tagged
Recombinant Mesocricetus auratus T-cell surface glycoprotein CD4 (Cd4), partial CSB-EP4837MRG Cd4 E.coli N-terminal GST-tagged and C-terminal Strep II-tagged
Recombinant Dog T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-EP004966DO1 CD8A E.coli N-terminal 10xHis-tagged
Recombinant Human T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-MP004966HU CD8A Mammalian cell N-terminal 6xHis-Myc-tagged
Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-EP004966BO CD8A E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-EP004966HU CD8A E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-YP004966BO CD8A Yeast N-terminal 6xHis-tagged

抗體

● 結(jié)核桿菌抗體:

產(chǎn)品名稱 貨號 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
mpt63 Antibody CSB-PA14907A0Rb mpt63 Mycobacterium tuberculosis ELISA
pstS1 Antibody CSB-PA14919A0Rb pstS1 Mycobacterium tuberculosis ELISA
mpt51 Antibody CSB-PA14937A0Rb mpt51 Mycobacterium tuberculosis ELISA
mpt64 Antibody CSB-PA14949A0Rb mpt64 Mycobacterium tuberculosis ELISA, WB
choD Antibody CSB-PA18185A0Rb choD Mycobacterium tuberculosis ELISA
fbpA Antibody CSB-PA18279A0Rb fbpA Mycobacterium tuberculosis ELISA, WB
MT2731 Antibody CSB-PA300323LA01MVZ MT2731 Mycobacterium tuberculosis ELISA
cyp125 Antibody CSB-PA351308HA01MVZ cyp125 Mycobacterium tuberculosis ELISA
mpt63 Antibody CSB-PA358712YA01MVZ mpt63 Mycobacterium tuberculosis ELISA, WB
mpt64 Antibody CSB-PA358713YA01FSG mpt64 Mycobacterium tuberculosis ELISA
esxB Antibody CSB-PA363658YA01MVZ esxB Mycobacterium tuberculosis ELISA
inhA Antibody CSB-PA363781HA01MVZ inhA Mycobacterium tuberculosis ELISA
lepB Antibody CSB-PA604637LA01MVZ lepB Mycobacterium tuberculosis ELISA
choD Antibody CSB-PA704121EA01MVZ choD Mycobacterium tuberculosis ELISA
mpt64 Antibody CSB-PA14947A0Rb mpt64 Mycobacterium tuberculosis ELISA, WB
fbpC Antibody CSB-PA363614LA01MVZ fbpC Mycobacterium tuberculosis ELISA, WB
lprG Antibody CSB-PA358685ZA01MVZ lprG Mycobacterium tuberculosis ELISA, WB
mtr Antibody CSB-PA517031ZA01MVZ mtr Mycobacterium tuberculosis ELISA, WB

● 結(jié)核桿菌研究熱門靶點(diǎn)抗體:

產(chǎn)品名稱 貨號 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
ALB Monoclonal Antibody CSB-MA076752 ALB Human ELISA, WB, IHC
ALB Antibody CSB-PA00260E1Rb ALB Canine ELISA
ALB Antibody CSB-PA00950E1Rb ALB Bovine ELISA
ALB Antibody CSB-PA001561LA01HU ALB Human, Mouse ELISA, WB, IHC, IF
Alb Antibody CSB-PA001561LA01RA Alb Rat ELISA, WB
ALB Antibody CSB-PA001561GA01HU ALB Human, Mouse, Rat ELISA, IHC
ALB Antibody CSB-PA079344 ALB Human ELISA, WB, IHC
BSA Antibody CSB-PA592874 ALB Bovine ELISA, WB
BSA Antibody CSB-PA272395 ALB Bovine ELISA, WB
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD4 Monoclonal Antibody CSB-MA000228 CD4 Human,Mouse,Rat ELISA, IHC
CD4 Monoclonal Antibody,Purified CSB-MA783233 CD4 Human ELISA, FC
CD4 Antibody CSB-PA004935ESR2HU CD4 Human ELISA, IHC
Phospho-CD4 (S433) Antibody CSB-PA070257 CD4 Human, Mouse ELISA, IHC, IF
CD4 Antibody CSB-PA001453 CD4 Human, Mouse ELISA, WB, IHC, IF
CD4 Antibody CSB-PA004935GA01HU CD4 Human, Mouse, Rat ELISA, WB
CD8A Recombinant Monoclonal Antibody CSB-RA934881A0HU CD8A Human ELISA, WB, IHC, IP
CD8A Monoclonal Antibody,Purified CSB-MA927984 CD8A Human ELISA, FC
CD8A Antibody CSB-PA004966LA01HU CD8A Human ELISA, IHC