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  4. Recombinant Candida albicans Agglutinin-like protein 3 (ALS3), partial

Recombinant Candida albicans Agglutinin-like protein 3 (ALS3), partial

In Stock
  • 中文名稱：
    Recombinant Candida albicans Agglutinin-like protein 3(ALS3) ,partial
  • 貨號(hào)：
    CSB-EP527942CZF
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    ALS3
  • Uniprot No.：
  • 別名：
    ALS3; ALD8; Agglutinin-like protein 3; 3D9 antigen; Adhesin 3
  • 種屬：
    Candida albicans (Yeast)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    37.9kDa
  • 表達(dá)區(qū)域：
    918-1119aa
  • 氨基酸序列
    VSVETESSTVTTAQTNPSVPTTESEVVFTTKGNNENGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQPTNNNGGGKAPSATSSPSTTTTANNDSVITGTTSTNQSQSQSQYNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-B2M-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    The recombinant Candida albicans ALS3 protein is a fusion protein consists of the Candida albicans ALS3 protein (918-1119aa) partnered with the N-terminal 10xHis-B2M tag and C-terminal Myc tag. It was produced in the E.coli. This recombinant ALS3 protein's purity is greater than 90% determined by SDS-PAGE. After electrophoresis, there is a 38 kDa protein band presented on the gel.

    Candida albicans is part of the normal human flora, and it grows on mucosal surfaces in healthy individuals. Resistance caused by the formation of the Candida albicans (C. albicans) biofilm is one of the main reasons for antifungal therapy failure. Thus, it is important to find indicators that predict C. albicans biofilm formation to provide evidence for the early prevention and treatment of the C. albicans biofilms. ALS3 as a member of the agglutinin-like sequence (ALS) gene family, it was differentially expressed in free, antifungal, drug-sensitive C. albicans. A larger number of tandem repeats is associated with increased adherence when different-size alleles are expressed in C. albicans, but not when they are expressed in S. cerevisiae. ALS3 mediates adherence to diverse host substrates. ALS3 also binds to host cell ferritin and enables C. albicans to utilize this protein as a source of iron. Because of its multiple functions and its high expression level in vivo, Als3 is a promising target for vaccines that induce protective cell-mediated and antibody responses.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall.
  • 蛋白家族：
    ALS family