Spike glycoprotein
S蛋白是一個(gè)很大的三聚體跨膜糖蛋白,它在病毒表面形成特殊的花冠結(jié)構(gòu),得名于其獨(dú)特的形狀,即一系列突出的棘刺。S蛋白含有兩個(gè)功能亞基:S1和S2。S1亞基中有兩個(gè)基本結(jié)構(gòu)域,稱為受體結(jié)合域(RBD)和N端域(NTD)。S2具有三個(gè)域,分別稱為Heptad Repeat(HR)、Central Helix(CH)和Connector Domain(CD)。S蛋白的主要功能是幫助病毒進(jìn)入和感染宿主細(xì)胞。它通過與宿主細(xì)胞表面的特定受體結(jié)合來實(shí)現(xiàn)這一點(diǎn)。在SARS-CoV-2的情況下,S蛋白與人體細(xì)胞表面的ACE2受體結(jié)合,從而啟動(dòng)感染過程。S1亞基負(fù)責(zé)識(shí)別并結(jié)合宿主細(xì)胞表面的受體,而S2亞基則負(fù)責(zé)將病毒包膜與宿主細(xì)胞膜融合,使病毒內(nèi)的遺傳物質(zhì)得以注入細(xì)胞,達(dá)到感染的目的。 S蛋白的信號(hào)通路主要涉及其與宿主細(xì)胞受體的相互作用和膜融合過程。當(dāng)S蛋白的RBD區(qū)域與宿主細(xì)胞表面的ACE2受體結(jié)合后,會(huì)觸發(fā)一系列的細(xì)胞內(nèi)信號(hào)傳導(dǎo)事件。這些事件可能涉及細(xì)胞內(nèi)的多種分子和通路,最終導(dǎo)致病毒包膜與宿主細(xì)胞膜的融合,以及病毒遺傳物質(zhì)的釋放和感染過程的完成。全面地理解S蛋白在病毒感染過程中的作用機(jī)制,有利于開發(fā)針對(duì)冠狀病毒的疫苗和抗病毒藥物提供關(guān)鍵信息。
熱銷產(chǎn)品
● Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (Active)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Predicted band size: 51.1 kDa
Observed band size: 66 kDa due to glycosylation
Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 2 μg/ml can bind Biotinylated Anti-SARS-CoV-2-S Antibody (CSB-RA33245D1GMY), the EC50 of SARS-CoV-2-S1-RBD protein is 106.2-131.2 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized human ACE2 (CSB-MP866317HU) at 2 μg/ml can bind SARS-CoV-2-S1-RBD, the EC50 of SARS-CoV-2-S1-RBD protein is 8.363-12.82 ng/ml.
● Recombinant Human SARS coronavirus Spike glycoprotein (S), partial (Active)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD at 2 μg/ml can bind Paguma larvata ACE2 (CSB-MP684964PAL), the EC50 is 5.056-7.559 ng/ml.
Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD at 5 μg/ml can bind human ACE2 (CSB-MP866317HU), the EC50 is 7.941-10.49 ng/ml.
Spike glycoprotein Antibodies
Spike glycoprotein for Human coronavirus OC43
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA336163EA01HIY | S Antibody | Human coronavirus OC43 | ELISA |
Spike glycoprotein for Bovine coronavirus
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA333052LA01BJO | S Antibody | Bovine coronavirus | ELISA |
CSB-PA333052LC01BJO | S Antibody, FITC conjugated | Bovine coronavirus | |
CSB-PA333052LD01BJO | S Antibody, Biotin conjugated | Bovine coronavirus | ELISA |
Spike glycoprotein for Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-RA33245A0GMY | S Recombinant Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA |
CSB-RA33245A1GMY | S Recombinant Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA, Neutralising |
CSB-RA33245B1GMY | S Recombinant Monoclonal Antibody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-RA33245C1GMY | S Recombinant Monoclonal Antibody, FITC conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | |
CSB-RA33245D1GMY | S Recombinant Monoclonal Antibody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-RA33245A2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA, Neutralising |
CSB-EAP33245 | SARS-CoV-2 Spike RBD Antibody Pair 1 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
CSB-RA33245B2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-RA33245C2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody, FITC conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-RA33245D2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-MA33245A2m | S Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-MA33245A1m | S Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-MA33245A0m | S Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-PA33245YA01GMY | S Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-PA33245YD01GMY | S Antibody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-PA33245YA11GMY | S Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-PA33245YB11GMY | S Antibody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-PA33245YC11GMY | S Antibody, FITC conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | |
CSB-PA33245YD11GMY | S Antibody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-EAP33255A1 | SARS-CoV-2 N Antibody Pair 1 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
CSB-EAP33255A2 | SARS-CoV-2 N Antibody Pair 2 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
CSB-EAP33255A3 | SARS-CoV-2 N Antibody Pair 3 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
CSB-EAP33255A4 | SARS-CoV-2 N Antibody Pair 4 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
Spike glycoprotein Proteins
Spike glycoprotein Proteins for Human coronavirus 229E (HCoV-229E)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP321366HIT CSB-BP321366HIT CSB-MP321366HIT CSB-EP321366HIT-B |
Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP321366HIT | Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | E.coli |
CSB-MP321366HIT1 | Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | Mammalian cell |
Spike glycoprotein Proteins for Bos taurus (Bovine)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP333052BJO | Recombinant Bovine coronavirus Spike glycoprotein (S), partial | Yeast |
CSB-EP333052BJO | Recombinant Bovine coronavirus Spike glycoprotein (S), partial | E.coli |
Spike glycoprotein Proteins for Human coronavirus OC43 (HCoV-OC43)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP336163HIY | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Yeast |
CSB-MP336163HIY CSB-EP336163HIY-B |
Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP336163HIY | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | E.coli |
CSB-EP336163HIY1 | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | E.coli |
CSB-BP336163HIY | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Baculovirus |
CSB-MP336163HIY1 | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Mammalian cell |
Spike glycoprotein Proteins for Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-EP348663HQE CSB-BP348663HQE CSB-EP348663HQE-B |
Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP348663HQE | Recombinant Human SARS coronavirus Spike glycoprotein (S), partial (Active) | Mammalian cell |
CSB-YP348663HQE | Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | Yeast |
CSB-YP348663HQEa4 | Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | Yeast |
Spike glycoprotein Proteins for Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP607323HIW CSB-BP607323HIW CSB-EP607323HIW-B |
Recombinant Human coronavirus HKU1 Nucleoprotein (N) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
CSB-EP607323HIW | Recombinant Human coronavirus HKU1 Nucleoprotein (N) | E.coli |
CSB-EP607323HIWc7 | Recombinant Human coronavirus HKU1 Nucleoprotein (N) | E.coli |
CSB-MP607323HIW | Recombinant Human coronavirus HKU1 Nucleoprotein (N) | Mammalian cell |
Spike glycoprotein Proteins for Human coronavirus NL63 (HCoV-NL63)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-EP747509HIX CSB-BP747509HIX CSB-MP747509HIX CSB-EP747509HIX-B |
Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-YP747509HIX1 | Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | Yeast |
CSB-YP747509HIX | Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | Yeast |
Spike glycoprotein Proteins for Bovine coronavirus (strain vaccine) (BCoV) (BCV)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-BP333052BJO CSB-MP333052BJO CSB-EP333052BJO-B |
Recombinant Bovine coronavirus Spike glycoprotein (S), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP333052BJOc7 | Recombinant Bovine coronavirus Spike glycoprotein (S), partial | E.coli |
Spike glycoprotein Proteins for Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Spike glycoprotein Proteins for Severe acute respiratory syndrome coronavirus (SARS-CoV)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-MP348663HQEc7 | Recombinant Severe acute respiratory syndrome coronavirus Spike glycoprotein (S), partial | Mammalian cell |
Spike glycoprotein ELISA Kit
Spike glycoprotein ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL33241HU | Human SARS-CoV-2 S1 RBD IgG Antibody ELISA Kit | serum, plasma | |
CSB-EL33242HU | Human SARS-CoV-2 S1 RBD IgM Antibody ELISA Kit | serum, plasma |