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炎性細(xì)胞因子ELISA試劑盒

炎性細(xì)胞因子(inflammatory cytokines)是指調(diào)節(jié)各種炎癥反應(yīng)的細(xì)胞因子,主要包括促炎細(xì)胞因子和抗炎細(xì)胞因子兩種類(lèi)型。 促炎細(xì)胞因子和抗炎細(xì)胞因子之間的平衡對(duì)于維持免疫系統(tǒng)的正常功能和組織修復(fù)至關(guān)重要。

促炎細(xì)胞因子(Pro-inflammatory cytokines)

促炎細(xì)胞因子主要由Th1細(xì)胞、CD4+細(xì)胞、巨噬細(xì)胞和樹(shù)突狀細(xì)胞產(chǎn)生,參與炎癥反應(yīng)的上調(diào),以IL-1β、IL-6、IL-8、IL-12、IL-18、TNF-α和IFN-γ等促炎細(xì)胞因子最為常見(jiàn)。這些細(xì)胞因子在感染、組織損傷和其他病理刺激時(shí),起到激活和招募其他免疫細(xì)胞的作用,幫助機(jī)體對(duì)外來(lái)病原體和損傷做出適當(dāng)?shù)膽?yīng)答。

抗炎細(xì)胞因子(Anti-inflammatory cytokines)

抗炎細(xì)胞因子主要作用是抑制炎癥過(guò)程,平衡免疫反應(yīng),防止過(guò)度的炎癥反應(yīng)導(dǎo)致組織損傷和疾病發(fā)展。主要的抗炎細(xì)胞因子包括IL-1受體拮抗劑(IL-1ra)、IL-4、IL-10。值得注意的是,INF-α、TGF-β、IL-6、IL-11和IL-13在不同細(xì)胞類(lèi)型和環(huán)境下可分為抗炎或促炎細(xì)胞因子。

部分炎性細(xì)胞因子的功能特性

細(xì)胞因子 分類(lèi) 受體 主要功能
IL-1ra 抗炎細(xì)胞因子 IL-1R1(CD121a) 抑制IL-1的活性
IL-1β 促炎細(xì)胞因子 IL-1R1(CD121a) 致熱原性,促炎性,細(xì)胞增殖分化
IL-4 抗炎細(xì)胞因子 IL4R (CD124) B細(xì)胞和細(xì)胞毒性T細(xì)胞的增殖,增強(qiáng)MHC II類(lèi)分子表達(dá),刺激IgG和IgE的產(chǎn)生
IL-6 促/抗炎細(xì)胞因子 IL-6R(CD126), IL6ST (CD130) 誘導(dǎo)急性期蛋白合成、致熱原性
IL-8 促炎細(xì)胞因子 IL-8R 中性粒細(xì)胞和T細(xì)胞的趨化
IL-10 抗炎細(xì)胞因子 IL10R (CDw210) 抑制細(xì)胞因子的產(chǎn)生和單核細(xì)胞功能
IL-11 促/抗炎細(xì)胞因子 IL-11Ra, IL6ST (CD130) 促進(jìn)分化,誘導(dǎo)急性期蛋白,抑制Th1淋巴細(xì)胞
IL-12 促炎細(xì)胞因子 IL12RB1 (CD212) 激活自然殺傷細(xì)胞(NK細(xì)胞),啟動(dòng)吞噬細(xì)胞,引發(fā)內(nèi)毒素休克,增加對(duì)腫瘤的細(xì)胞毒性,導(dǎo)致惡病質(zhì)
IL-13 促/抗炎細(xì)胞因子 IL-13Rα1, IL-13Rα2 促進(jìn)B細(xì)胞增殖,誘導(dǎo)單核細(xì)胞分化,增強(qiáng)MHC II類(lèi)分子表達(dá)
IL-18 促炎細(xì)胞因子 IL-18Ra(CD218a) 招募單核細(xì)胞和T淋巴細(xì)胞,與IL-12協(xié)同誘導(dǎo)干擾素-γ的產(chǎn)生并抑制血管生成
INF-α 促/抗炎細(xì)胞因子 IFNAR1, IFNAR2 抗病毒、抗細(xì)胞增殖
TNF-α 促炎細(xì)胞因子 TNFR1, TNFR2 啟動(dòng)吞噬細(xì)胞,引發(fā)內(nèi)毒素休克
TGF-β 促/抗炎細(xì)胞因子 TGF-βR1, 2, 3 抑制T和B細(xì)胞增殖,抑制造血作用,促進(jìn)傷口愈合

炎性細(xì)胞因子相關(guān)試劑盒

華美生物提供高質(zhì)量、高靈敏度的炎性細(xì)胞因子ELISA試劑盒,廣泛應(yīng)用于炎癥過(guò)程和免疫反應(yīng)研究,為定量測(cè)定炎性細(xì)胞因子水平提供可靠的檢測(cè)結(jié)果,有助于揭示免疫和炎癥反應(yīng)的機(jī)制,助力免疫性疾病或炎癥性疾病的藥物研發(fā)。

靶點(diǎn) 貨號(hào) 產(chǎn)品名稱(chēng) 靈敏度
AIF1 CSB-EL001490MO Mouse Allograft inflammatory factor 1(AIF1) ELISA kit 1.10 ng/ml
AIF1 CSB-EL001490HU Human Allograft inflammatory factor 1(AIF1) ELISA kit 1.9 ng/mL
CC16 CSB-E08681r Rat Clara cell protein,CC16 ELISA Kit 0.78 pg/mL
CCL11 CSB-E04533h Human eosinophil chemotactic factor,ECF ELISA Kit 7.8 pg/mL
CCL17 CSB-E09257h Human thymus activation regulated chemokine,TARC ELISA Kit 3.9 pg/mL
CCL17 CSB-EL004780RH Monkey C-C motif chemokine 17(CCL17) ELISA kit 9.8 pg/mL
CCL2 CSB-E04655h Human monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit 1.56 pg/ml
CCL2 CSB-E07430m Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit 19.5 pg/mL
CCL2 CSB-E07429r Rat monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit 7.8 pg/mL
CCL20 CSB-E04669r Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit 1.56 pg/mL
CCL20 CSB-E04667h Human Macrophage Inflammatory Protein-3α,MIP-3α ELISA kit 3.9 pg/mL
CCL23 CSB-E07309h Human Myeloid Progenitor Inhibitory Factor 1,MPIF-1 ELISA Kit 9.7 pg/mL
CCL25 CSB-EL004789MO Mouse C-C motif chemokine 25(CCL25) ELISA kit 7.8 pg/mL
CCL26 CSB-EL004790HU Human C-C motif chemokine 26(CCL26) ELISA kit 3.9 pg/mL
CCL3 CSB-E04663m Mouse Macrophage Inflammatory Protein 1α,MIP-1α ELISA kit 5.8 pg/mL
CCL5 CSB-E17375h Human C-C motif chemokine 5 (CCL5/D17S136E/SCYA5) ELISA kit 2.307 pg/mL
CCL7 CSB-E07426m Mouse monocyte chemotactic protein 3,MCP-3 ELISA kit 0.39 pg/mL
CCR2 CSB-E14200h Human CC-Chemokine Receptor 2,CCR2 ELISA Kit 5.86 pg/mL
CRP CSB-E06847Rb Rabbit C-Reactive Protein,CRP ELISA Kit 2 pg/mL
CRP CSB-EL005991HA Hamster C-reactive protein(CRP) ELISA Kit 3.12 ng/mL
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