心血管疾病
心血管疾病是影響心臟和血管系統(tǒng)的一類疾病,包括心臟病和外周血管疾病。心臟病主要涉及心臟結(jié)構(gòu)的異常,如冠狀動(dòng)脈疾病,它是由于冠狀動(dòng)脈供血不足導(dǎo)致心肌缺血或缺氧。外周血管疾病則影響除心臟外的血管,如上肢、下肢及軀干的供血血管異常。
針對(duì)特定受體和信號(hào)通路的靶向治療是心血管疾病藥物研發(fā)的重要方向,如:
- G蛋白偶聯(lián)受體(GPCR):GPCR是一大類細(xì)胞表面受體,它們?cè)谛难芟到y(tǒng)中調(diào)節(jié)多種生理過程,包括血壓和心率的控制。Apelin受體(APLNR)是GPCR家族的一員,它在心血管疾病中具有潛在的治療作用。通過設(shè)計(jì)特異性激動(dòng)劑,可以激活G蛋白信號(hào)通路,減少有害的心肌肥厚,為心力衰竭治療提供新策略。
- 血栓素A2受體(TP):TP是血小板聚集和血管平滑肌細(xì)胞收縮的關(guān)鍵調(diào)節(jié)因子,是治療動(dòng)脈粥樣硬化和高血壓的潛在靶點(diǎn)。通過研究TP與其配體的結(jié)合模式,可以設(shè)計(jì)出特異性的TP抑制劑,以減少心血管疾病的發(fā)生。
- 離子通道:心臟和血管平滑肌細(xì)胞的離子通道在調(diào)節(jié)心臟節(jié)律和血管張力中起著核心作用。針對(duì)特定離子通道的藥物,如鈣通道阻滯劑,已經(jīng)被廣泛用于治療高血壓和心絞痛。
- 酶抑制劑:例如,血管緊張素轉(zhuǎn)換酶(ACE)抑制劑和血管緊張素受體阻滯劑(ARBs)通過阻斷腎素-血管緊張素系統(tǒng)來降低血壓,減少心血管疾病的風(fēng)險(xiǎn)。
- 脂肪酸和脂質(zhì)代謝調(diào)節(jié)劑:他汀類藥物通過抑制HMG-CoA還原酶來降低膽固醇水平,減少心血管疾病的風(fēng)險(xiǎn)。
- 抗凝血藥物:通過減少血液凝固來預(yù)防血栓形成,用于治療或預(yù)防中風(fēng)和心肌梗死。
心血管疾病藥物靶點(diǎn)
- ANGPT2
- ANGPTL3
- C1R
- C1S
- C5
- CD19
- CD247
- CD274
- CD38
- CD3E
- CD40
- CD47
- CSF2RA
- CSF3R
- DNA2
- DRD4
- EGFR
- EpoR
- ERBB2
- F10
- F11
- F5
- F7
- F8
- F9
- FLT1
- GHR
- GLP1R
- GPRC5D
- HGF
- HLA-DRA
- ICAM1
- IFNAR1
- IGF1R
- IL1B
- IL1R1
- IL2RA
- IL5
- IL6
- IL6R
- IL6ST
- INSR
- KIT
- KLKB1
- MPL
- MS4A1
- NGFR
- NPR1
- PCSK9
- PDCD1
- PDGFRB
- PGF
- PKP2
- PLG
- PTCRA
- RXFP1
- SDC1
- SELE
- SELP
- SLAMF7
- TIGIT
- TNF
- TNFRSF17
- TNFSF11
- TNFSF13
- TTR
- VEGFA
- VEGFD
- VWF
心血管疾病靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CSB-MP023974HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
CSB-MP882153HU
Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC50 is 8.847-10.38 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP001707HU(A4)
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL
● 重組抗體
CSB-RA244537A0HU
Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
CSB-RA011087MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.
CSB-RA159341A0HU
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
---|---|---|---|---|
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
● ELISA試劑盒
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 檢測(cè)范圍 | 靈敏度 |
---|---|---|---|---|
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit | CSB-E11724h | ANGPTL3 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit | CSB-EL001711MO | ANGPTL3 | 31.25 pg/mL-2000 pg/mL | 10.24 pg/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |
Mouse Complement 5,C5 ELISA Kit | CSB-E13802m | C5 | 0.25 ng/mL-16 ng/mL | 0.06 ng/mL |
Rat Complement fragment 5,C5 ELISA Kit | CSB-E14363r | C5 | 9.38 ng/mL-600 ng/mL | 2.34 ng/mL |
Monkey complement C5 (C5) ELISA kit | CSB-EL003995MK | C5 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | CSB-E09884h | CD38 | 0.9 ng/mL-60 ng/mL | 0.225 ng/mL |
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | CSB-EL004929MO | CD38 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human epidermal growth factor receptor,EGFR ELISA Kit | CSB-E12124h | EGFR | 0.312 ng/mL-20 ng/mL | 0.019 ng/mL |
Human Erythropoietin receptor,EPOR ELISA Kit | CSB-E04537h | EPOR | 0.156 ng/ml - 10 ng/ml | 0.039 ng/ml |