先天性遺傳性新生兒疾病和畸形
先天性遺傳性新生兒疾病和畸形是由遺傳因素引起的新生兒健康問題,這些疾病可能在出生時或生后的早期就已經(jīng)存在。包括代謝性疾病、血液疾病、先天性心臟病、神經(jīng)管缺陷等。
目前,先天性遺傳性新生兒疾病和畸形的藥物研發(fā)正在積極探索當中,主要集中在以下幾個方向:
- 基因治療:基因療法是針對遺傳性疾病的一種治療方法,通過替換、修復或調(diào)控致病基因來治療疾病。例如,針對先天性黑矇(一種遺傳性視網(wǎng)膜疾病)的基因治療研究正在進行,旨在通過基因療法恢復受損的視網(wǎng)膜功能。
- 代謝性疾病治療:對于代謝性疾病,研發(fā)的新藥可能針對特定的代謝途徑,如針對PKU的治療方法,除了傳統(tǒng)的飲食控制外,正在研究能夠改善代謝途徑的藥物。
- 新生兒疾病篩查技術(shù):隨著串聯(lián)質(zhì)譜技術(shù)(MS/MS)和基因檢測技術(shù)的發(fā)展,新生兒疾病篩查變得更加高效和準確,有助于早期診斷和干預。
先天性遺傳性新生兒疾病和畸形藥物靶點
- ABCA4
- ABCD1
- ALB
- ALPL
- ANGPTL3
- APOA1
- APP
- ARSA
- C1R
- C1S
- C5
- CD14
- CD200R1
- CD247
- CD276
- CD34
- CD40LG
- CFTR
- COL7A1
- CSF2
- CSF2RA
- CSF3R
- CYP4V2
- DAG1
- DMD
- DMPK
- DNA2
- DYSF
- ELANE
- EPOR
- F10
- F11
- F7
- F8
- F9
- FANCA
- FGFR3
- FKRP
- FSHR
- FXN
- GAA
- GALC
- GHR
- GLP1R
- HBB
- HEXA
- HEXB
- IDS
- IDUA
- IFNAR1
- IFNGR1
- IGF1R
- IGF2R
- IL11RA
- IL12A
- IL13
- IL17A
- IL18
- IL1A
- IL1B
- IL1R1
- IL1RL1
- IL2
- IL22
- IL25
- IL2RA
- IL2RG
- IL31
- IL33
- IL4
- IL4R
- IL6
- IL6R
- IL6ST
- INSR
- KIT
- KLK5
- KLK7
- KLKB1
- LEPR
- MECP2
- MT-ND4
- OTC
- PAH
- PCSK9
- PDCD1
- PGF
- PTCRA
- RHD
- RHO
- RPE65
- RPGR
- SELP
- SERPINA1
- SGSH
- SIRT6
- SNAP25
- SOST
- SPINK5
- TFPI
- TFRC
- TGFB1
- TNF
- TNFRSF1A
- TNFRSF4
- TNFSF4
- TSLP
- TTR
- UBE3A
- UGT1A1
- USH2A
- VEGFA
先天性遺傳性新生兒疾病和畸形靶點相關(guān)產(chǎn)品推薦
● 靶點蛋白
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R,the EC50 is 12.68-14.23 ng/mL.
CSB-MP023437HU
Measured by its binding ability in a functional ELISA. Immobilized Human TFPI at 1 μg/ml can bind Anti-TFPI recombinant antibody (CSB-RA023437MA01HU), the EC50 is 1.242-1.788 ng/mL.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP3648HU
Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2μg/mL can bind Anti-TFRC recombinant antibody (CSB-RA023441MA1HU), the EC50 is 3.305-8.220 ng/mL.
CSB-MP009514HUb1
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
CSB-MP011649HU3
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.
CSB-MP733578HU
Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.
● 重組抗體
CSB-RA011087MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.
CSB-RA019677MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA019677MA1HU (red line) at 1:100.
CSB-RA011621MA1HU
Overlay Peak curve showing NIH/3T3 cells surface stained with CSB-RA011621MA1HU (red line) at 1:50.
CSB-RA003995MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.
產(chǎn)品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
---|---|---|---|---|
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
APP Recombinant Monoclonal Antibody | CSB-RA994273A0HU | APP | Human, Mouse, Rat | ELISA, WB, IF |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD34 Recombinant Monoclonal Antibody | CSB-RA004926A0HU | CD34 | Human | ELISA, IHC |
DMD Recombinant Monoclonal Antibody | CSB-RA271553A0HU | DMD | Human | ELISA, IHC |
ELANE Recombinant Monoclonal Antibody | CSB-RA200985A0HU | ELANE | Human | ELISA, IHC, FC |
F10 Recombinant Monoclonal Antibody | CSB-RA599469A0HU | F10 | Human | ELISA, IHC |
F9 Recombinant Monoclonal Antibody | CSB-RA923075A0HU | F9 | Human | ELISA, WB |
FGFR3 Recombinant Monoclonal Antibody | CSB-RA555849A0HU | FGFR3 | Human | ELISA, IF |
FGFR3 Recombinant Monoclonal Antibody | CSB-RA966627A0HU | FGFR3 | Human | ELISA, WB |
GAA Recombinant Monoclonal Antibody | CSB-RA566370A0HU | GAA | Human | ELISA, IHC |
GHR Recombinant Monoclonal Antibody | CSB-RA978909A0HU | GHR | Human | ELISA, IHC, IF |
GLP1R Recombinant Monoclonal Antibody | CSB-RA009514MA1HU | GLP1R | Human | ELISA |
IFNAR1 Recombinant Monoclonal Antibody | CSB-RA011046A0HU | IFNAR1 | Human | ELISA |
IGF1R Recombinant Monoclonal Antibody | CSB-RA011087MA1HU | IGF1R | Human | ELISA, FC |
IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | IL17A | Human | ELISA |
IL1R1 Recombinant Monoclonal Antibody | CSB-RA011621MA1HU | IL1R1 | Human | ELISA, FC |
IL2RA Recombinant Monoclonal Antibody | CSB-RA011649MA1HU | IL2RA | Human | ELISA, IF |
IL4 Recombinant Monoclonal Antibody | CSB-RA240377A0HU | IL4 | Human | ELISA, IHC |
● ELISA試劑盒
產(chǎn)品名稱 | 貨號 | 靶點 | 檢測范圍 | 靈敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit | CSB-E11724h | ANGPTL3 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit | CSB-EL001711MO | ANGPTL3 | 31.25 pg/mL-2000 pg/mL | 10.24 pg/mL |
Human apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08103h | APOA1 | 1.4 ng/mL-1000 ng/mL | 0.7 ng/mL |
Rat apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08105r | APOA1 | 0.14 ng/ml-100 ng/ml. | 0.14 ng/ml. |
Pig apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E06834p | APOA1 | 80 μg/mL-2000 μg/mL | 50 μg/mL |
Mouse apolipoprotein A1(Apo-A1) ELISA Kit | CSB-E08104m | APOA1 | 31.25 ng/mL-2000 ng/mL | 7.81 ng/mL |
Rabbit apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E09804Rb | APOA1 | 6.25 μg/mL-400 μg/mL | 1.56 μg/mL |
Bovine Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913BO | APOA1 | 78 ng/mL-5000 ng/mL | 19.5 ng/mL |
Dog Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913DO | APOA1 | 28.12 ng/mL-1800 ng/mL | 7 ng/mL |
Rat Amyloid beta A4 protein(APP) ELISA kit | CSB-EL001950RA | APP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |