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營養(yǎng)代謝病

營養(yǎng)代謝病是一組由營養(yǎng)代謝異常引起的疾病,包括但不限于糖尿病、肥胖、心血管疾病、脂肪肝等。營養(yǎng)代謝病通常與體內(nèi)營養(yǎng)物質(zhì)的代謝失衡有關(guān),可能是由于酶的缺陷、激素水平異常、遺傳因素或生活方式等多種因素引起的。

營養(yǎng)代謝病的藥物研發(fā)聚焦于多個(gè)關(guān)鍵靶點(diǎn),以下是一些重要的靶點(diǎn)及其研發(fā)進(jìn)展:

  • GLP-1R/GIPR:受體和GIP受體是治療肥胖和糖尿病的重要靶點(diǎn)。基于這些靶點(diǎn)的藥物能夠改善胰島素分泌和降低血糖水平。例如,Amgen的AMG 133(Anti-GIPR單抗融合GLP-1)在治療肥胖的Ⅰ期臨床數(shù)據(jù)中表現(xiàn)出顯著的減重效果。
  • INHBE:INHBE(Inhibin beta E chain)是TGF-β超家族的成員,主要在肝臟表達(dá),與體脂分布和代謝健康相關(guān)。研究發(fā)現(xiàn)INHBE基因的功能喪失突變與較低的腰臀比和良好的代謝特征相關(guān),表明INHBE是潛在的治療靶點(diǎn)。
  • lysosomal AMPK(PEN2/Aldolase):AMPK是代謝穩(wěn)態(tài)的關(guān)鍵控制器。通過特定抑制PEN2或Aldolase,可以模擬細(xì)胞葡萄糖饑餓,激活溶酶體AMPK,從而降低脂肪肝、緩解高血糖,為代謝疾病治療提供了新思路。
  • CIDEB:CIDEB基因與肝臟脂質(zhì)代謝相關(guān),Alnylam公司與再生元合作開發(fā)靶向CIDEB的RNAi療法,預(yù)計(jì)進(jìn)入臨床開發(fā)階段,為NASH治療提供了新的靶點(diǎn)。
  • SLC轉(zhuǎn)運(yùn)蛋白家族:SLC轉(zhuǎn)運(yùn)蛋白在多種代謝性疾病中起重要作用,包括二型糖尿病、高血壓等。SLC轉(zhuǎn)運(yùn)蛋白作為藥物靶點(diǎn)的研究顯示它們可以轉(zhuǎn)運(yùn)營養(yǎng)素、代謝物以及藥物分子,是慢性病重要的藥物靶點(diǎn)。
  • PCSK9:PCSK9(原蛋白轉(zhuǎn)化酶枯草桿菌酶 9 型)是降低膽固醇治療的熱門靶點(diǎn)?;赗NA干擾技術(shù)的PCSK9抑制劑,如inclisiran,已獲得批準(zhǔn)用于治療高膽固醇血癥。
  • GDF15:生長分化因子15(GDF15)是一種調(diào)節(jié)能量代謝的信號(hào)分子,其分泌受肝臟Glce的調(diào)控,影響機(jī)體肝脂代謝的穩(wěn)態(tài)平衡,可能成為對(duì)抗肥胖的潛在靶點(diǎn)1。
  • SLC13A5:SLC13A5作為一個(gè)具有極大開發(fā)潛力的靶點(diǎn),研究其在代謝性疾病中的作用機(jī)制以及藥物設(shè)計(jì)與開發(fā)具有重要意義。

營養(yǎng)代謝病靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP023974HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP009411HU Activity Verified

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

MS4A1 (CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP882153HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC50 is 8.847-10.38 ng/mL.

CSB-YP011664HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP001707HU(A4) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Human ATP-binding cassette sub-family D member 1 (ABCD1) (Active) CSB-CF001068HU ABCD1 in vitro E.coli expression system C-terminal 10xHis-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) CSB-AP005161HU CD86 Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Glucagon receptor (GCGR), partial (Active) CSB-MP009316HU1 GCGR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Growth hormone receptor (GHR), partial (Active) CSB-MP009411HU GHR Mammalian cell C-terminal hFc-tagged
Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active) CSB-MP009411HUj1-B GHR Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial (Active) CSB-MP009438MO1 Gipr Mammalian cell C-terminal 10xHis-tagged
Recombinant Rat Gastric inhibitory polypeptide receptor (Gipr), partial (Active) CSB-MP009438RA1 Gipr Mammalian cell C-terminal 10xHis-tagged
Recombinant Macaca Gastric inhibitory polypeptide receptor (GIPR), partial (Active) CSB-YP4825MOV GIPR Yeast N-terminal 6xHis-tagged
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) CSB-MP009514HUb1 GLP1R Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Interleukin-15 protein (IL15) (Active) CSB-AP001621HU IL15 E.Coli Tag-Free
Recombinant Human Interleukin-15 (IL15) (Active) CSB-AP004391HU IL15 E.coli Tag-Free
Recombinant Human Interleukin-17A (IL17A) (Active) CSB-AP004331HU IL17A E.coli Tag-Free

● 重組抗體

C5 Recombinant Monoclonal Antibody
CSB-RA003995MA1HU
CSB-RA003995MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
APP Recombinant Monoclonal Antibody CSB-RA994273A0HU APP Human, Mouse, Rat ELISA, WB, IF
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD80 Recombinant Monoclonal Antibody CSB-RA246383A0HU CD80 Human ELISA, WB, IHC, IP
CD86 Recombinant Monoclonal Antibody CSB-RA004965A0HU CD86 Human ELISA, WB
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
FGFR1 Recombinant Monoclonal Antibody CSB-RA008642MA1HU FGFR1 Human ELISA, IHC, IF, FC
GAA Recombinant Monoclonal Antibody CSB-RA566370A0HU GAA Human ELISA, IHC
GCGR Recombinant Monoclonal Antibody CSB-RA009316A1HU GCGR Human ELISA
GDF15 Recombinant Monoclonal Antibody CSB-RA285852A0HU GDF15 Human ELISA, IHC
GHR Recombinant Monoclonal Antibody CSB-RA978909A0HU GHR Human ELISA, IHC, IF
Gipr Recombinant Monoclonal Antibody CSB-RA009438MA1MO Gipr Mouse、Rat ELISA
GIPR Recombinant Monoclonal Antibody CSB-RA009438MA2HU GIPR Human ELISA, WB
GIPR Recombinant Monoclonal Antibody CSB-RA009438MA1HU GIPR Human, Macaca fascicularis ELISA
GLP1R Recombinant Monoclonal Antibody CSB-RA009514MA1HU GLP1R Human ELISA
IGF1R Recombinant Monoclonal Antibody CSB-RA011087MA1HU IGF1R Human ELISA, FC
IL17A Recombinant Monoclonal Antibody CSB-RA624104MA1HU IL17A Human ELISA

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測范圍 靈敏度
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit CSB-E11724h ANGPTL3 78 pg/mL-5000 pg/mL 19.5 pg/mL
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit CSB-EL001711MO ANGPTL3 31.25 pg/mL-2000 pg/mL 10.24 pg/mL
Human apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E08103h APOA1 1.4 ng/mL-1000 ng/mL 0.7 ng/mL
Rat apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E08105r APOA1 0.14 ng/ml-100 ng/ml. 0.14 ng/ml.
Pig apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E06834p APOA1 80 μg/mL-2000 μg/mL 50 μg/mL
Mouse apolipoprotein A1(Apo-A1) ELISA Kit CSB-E08104m APOA1 31.25 ng/mL-2000 ng/mL 7.81 ng/mL
Rabbit apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E09804Rb APOA1 6.25 μg/mL-400 μg/mL 1.56 μg/mL
Bovine Apolipoprotein A-I(APOA1) ELISA kit CSB-EL001913BO APOA1 78 ng/mL-5000 ng/mL 19.5 ng/mL
Dog Apolipoprotein A-I(APOA1) ELISA kit CSB-EL001913DO APOA1 28.12 ng/mL-1800 ng/mL 7 ng/mL
Rat Amyloid beta A4 protein(APP) ELISA kit CSB-EL001950RA APP 15.6 ng/mL-1000 ng/mL 3.9 ng/mL
Mouse Complement 5,C5 ELISA Kit CSB-E13802m C5 0.25 ng/mL-16 ng/mL 0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit CSB-E14363r C5 9.38 ng/mL-600 ng/mL 2.34 ng/mL
Monkey complement C5 (C5) ELISA kit CSB-EL003995MK C5 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Uncharacterized protein C9orf72(C9orf72) ELISA kit CSB-EL004345HU C9orf72 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit CSB-E09884h CD38 0.9 ng/mL-60 ng/mL 0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit CSB-EL004929MO CD38 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit CSB-E04716h CD40LG 0.312 ng/mL-20 ng/mL 0.078 ng/mL