營養(yǎng)代謝病
營養(yǎng)代謝病是一組由營養(yǎng)代謝異常引起的疾病,包括但不限于糖尿病、肥胖、心血管疾病、脂肪肝等。營養(yǎng)代謝病通常與體內(nèi)營養(yǎng)物質(zhì)的代謝失衡有關(guān),可能是由于酶的缺陷、激素水平異常、遺傳因素或生活方式等多種因素引起的。
營養(yǎng)代謝病的藥物研發(fā)聚焦于多個(gè)關(guān)鍵靶點(diǎn),以下是一些重要的靶點(diǎn)及其研發(fā)進(jìn)展:
- GLP-1R/GIPR:受體和GIP受體是治療肥胖和糖尿病的重要靶點(diǎn)。基于這些靶點(diǎn)的藥物能夠改善胰島素分泌和降低血糖水平。例如,Amgen的AMG 133(Anti-GIPR單抗融合GLP-1)在治療肥胖的Ⅰ期臨床數(shù)據(jù)中表現(xiàn)出顯著的減重效果。
- INHBE:INHBE(Inhibin beta E chain)是TGF-β超家族的成員,主要在肝臟表達(dá),與體脂分布和代謝健康相關(guān)。研究發(fā)現(xiàn)INHBE基因的功能喪失突變與較低的腰臀比和良好的代謝特征相關(guān),表明INHBE是潛在的治療靶點(diǎn)。
- lysosomal AMPK(PEN2/Aldolase):AMPK是代謝穩(wěn)態(tài)的關(guān)鍵控制器。通過特定抑制PEN2或Aldolase,可以模擬細(xì)胞葡萄糖饑餓,激活溶酶體AMPK,從而降低脂肪肝、緩解高血糖,為代謝疾病治療提供了新思路。
- CIDEB:CIDEB基因與肝臟脂質(zhì)代謝相關(guān),Alnylam公司與再生元合作開發(fā)靶向CIDEB的RNAi療法,預(yù)計(jì)進(jìn)入臨床開發(fā)階段,為NASH治療提供了新的靶點(diǎn)。
- SLC轉(zhuǎn)運(yùn)蛋白家族:SLC轉(zhuǎn)運(yùn)蛋白在多種代謝性疾病中起重要作用,包括二型糖尿病、高血壓等。SLC轉(zhuǎn)運(yùn)蛋白作為藥物靶點(diǎn)的研究顯示它們可以轉(zhuǎn)運(yùn)營養(yǎng)素、代謝物以及藥物分子,是慢性病重要的藥物靶點(diǎn)。
- PCSK9:PCSK9(原蛋白轉(zhuǎn)化酶枯草桿菌酶 9 型)是降低膽固醇治療的熱門靶點(diǎn)?;赗NA干擾技術(shù)的PCSK9抑制劑,如inclisiran,已獲得批準(zhǔn)用于治療高膽固醇血癥。
- GDF15:生長分化因子15(GDF15)是一種調(diào)節(jié)能量代謝的信號(hào)分子,其分泌受肝臟Glce的調(diào)控,影響機(jī)體肝脂代謝的穩(wěn)態(tài)平衡,可能成為對(duì)抗肥胖的潛在靶點(diǎn)1。
- SLC13A5:SLC13A5作為一個(gè)具有極大開發(fā)潛力的靶點(diǎn),研究其在代謝性疾病中的作用機(jī)制以及藥物設(shè)計(jì)與開發(fā)具有重要意義。
營養(yǎng)代謝病藥物靶點(diǎn)
- ABCD1
- ALPL
- AMY3
- ANGPTL3
- APOA1
- APP
- ARSA
- C5
- C9orf72
- CASR
- CD2
- CD247
- CD28
- CD38
- CD40
- CD40LG
- CD80
- CD86
- CNTFR
- CSF3R
- CTLA4
- EpoR
- FANCA
- FGF21
- FGF23
- FGFR1
- FXN
- GAA
- GALC
- GBA1
- GCGR
- GDF15
- GHR
- GIPR
- GK
- GLP1R
- GLP2R
- GRN
- HEXA
- HEXB
- IAPP
- IDS
- IDUA
- Ifngr1
- IGF1R
- IGF2R
- IL10RA
- IL15
- IL17A
- IL1A
- IL1B
- IL1R1
- IL2RA
- IL2RG
- IL6
- INSR
- KLB
- LEPR
- LPL
- MADCAM1
- MT-ND4
- NPY2R
- OTC
- PAH
- PCSK9
- PDCD1
- PGF
- PTHLH
- SGSH
- SIRT6
- SLC25A21
- SORT1
- SOST
- TARDBP
- TFRC
- TGFB1
- TMPRSS6
- TNF
- TNFRSF17
- TNFSF11
- TTR
- TYRO3
- UGT1A1
- VEGFA
營養(yǎng)代謝病靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CSB-MP023974HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
CSB-MP882153HU
Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC50 is 8.847-10.38 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP001707HU(A4)
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL
● 重組抗體
CSB-RA003995MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.
CSB-RA244537A0HU
Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
CSB-RA004936MA1HU
Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.
CSB-RA006163MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
---|---|---|---|---|
APP Recombinant Monoclonal Antibody | CSB-RA994273A0HU | APP | Human, Mouse, Rat | ELISA, WB, IF |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD80 Recombinant Monoclonal Antibody | CSB-RA246383A0HU | CD80 | Human | ELISA, WB, IHC, IP |
CD86 Recombinant Monoclonal Antibody | CSB-RA004965A0HU | CD86 | Human | ELISA, WB |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
FGFR1 Recombinant Monoclonal Antibody | CSB-RA008642MA1HU | FGFR1 | Human | ELISA, IHC, IF, FC |
GAA Recombinant Monoclonal Antibody | CSB-RA566370A0HU | GAA | Human | ELISA, IHC |
GCGR Recombinant Monoclonal Antibody | CSB-RA009316A1HU | GCGR | Human | ELISA |
GDF15 Recombinant Monoclonal Antibody | CSB-RA285852A0HU | GDF15 | Human | ELISA, IHC |
GHR Recombinant Monoclonal Antibody | CSB-RA978909A0HU | GHR | Human | ELISA, IHC, IF |
Gipr Recombinant Monoclonal Antibody | CSB-RA009438MA1MO | Gipr | Mouse、Rat | ELISA |
GIPR Recombinant Monoclonal Antibody | CSB-RA009438MA2HU | GIPR | Human | ELISA, WB |
GIPR Recombinant Monoclonal Antibody | CSB-RA009438MA1HU | GIPR | Human, Macaca fascicularis | ELISA |
GLP1R Recombinant Monoclonal Antibody | CSB-RA009514MA1HU | GLP1R | Human | ELISA |
IGF1R Recombinant Monoclonal Antibody | CSB-RA011087MA1HU | IGF1R | Human | ELISA, FC |
IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | IL17A | Human | ELISA |
● ELISA試劑盒
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 檢測范圍 | 靈敏度 |
---|---|---|---|---|
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit | CSB-E11724h | ANGPTL3 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit | CSB-EL001711MO | ANGPTL3 | 31.25 pg/mL-2000 pg/mL | 10.24 pg/mL |
Human apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08103h | APOA1 | 1.4 ng/mL-1000 ng/mL | 0.7 ng/mL |
Rat apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08105r | APOA1 | 0.14 ng/ml-100 ng/ml. | 0.14 ng/ml. |
Pig apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E06834p | APOA1 | 80 μg/mL-2000 μg/mL | 50 μg/mL |
Mouse apolipoprotein A1(Apo-A1) ELISA Kit | CSB-E08104m | APOA1 | 31.25 ng/mL-2000 ng/mL | 7.81 ng/mL |
Rabbit apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E09804Rb | APOA1 | 6.25 μg/mL-400 μg/mL | 1.56 μg/mL |
Bovine Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913BO | APOA1 | 78 ng/mL-5000 ng/mL | 19.5 ng/mL |
Dog Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913DO | APOA1 | 28.12 ng/mL-1800 ng/mL | 7 ng/mL |
Rat Amyloid beta A4 protein(APP) ELISA kit | CSB-EL001950RA | APP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
Mouse Complement 5,C5 ELISA Kit | CSB-E13802m | C5 | 0.25 ng/mL-16 ng/mL | 0.06 ng/mL |
Rat Complement fragment 5,C5 ELISA Kit | CSB-E14363r | C5 | 9.38 ng/mL-600 ng/mL | 2.34 ng/mL |
Monkey complement C5 (C5) ELISA kit | CSB-EL003995MK | C5 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Uncharacterized protein C9orf72(C9orf72) ELISA kit | CSB-EL004345HU | C9orf72 | 31.25 pg/mL-2000 pg/mL | 7.8 pg/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human soluble cluster of differentiation 28,sCD28 ELISA Kit | CSB-E09296h | CD28 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | CSB-E09884h | CD38 | 0.9 ng/mL-60 ng/mL | 0.225 ng/mL |
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | CSB-EL004929MO | CD38 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E04716h | CD40LG | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |