Your Good Partner in Biology Research

乳腺癌

乳腺癌是一種起源于乳腺上皮細(xì)胞的惡性腫瘤,是女性中最常見的癌癥之一,也是導(dǎo)致女性癌癥死亡的主要原因之一。乳腺癌的發(fā)病率與多種因素有關(guān),包括遺傳、年齡、激素水平、生活方式等。根據(jù)腫瘤細(xì)胞的特征,乳腺癌可以分為不同的亞型,如激素受體陽性(ER+/PR+)、人表皮生長因子受體2(HER2+)和三陰性乳腺癌(TNBC)等。

近年來,乳腺癌的治療和藥物研發(fā)取得了顯著進(jìn)展。特別是在靶向治療和免疫治療領(lǐng)域,新藥物和新療法的不斷涌現(xiàn)為患者帶來了更多的治療選擇和更好的預(yù)后。

靶向治療藥物

● HER2陽性乳腺癌

HER2陽性乳腺癌的治療在過去幾年中取得了重大進(jìn)展。ADC(抗體藥物偶聯(lián)物)類藥物治療是HER2陽性乳腺癌治療的重要突破。例如,DS-8201(Trastuzumab Deruxtecan)是一種針對(duì)HER2的ADC藥物,已經(jīng)在臨床試驗(yàn)中顯示出對(duì)HER2低表達(dá)和HER2陰性乳腺癌患者的潛在療效67。此外,T-DM1(Trastuzumab Emtansine)和T-DXd(Trastuzumab Deruxtecan)也在HER2陽性乳腺癌的治療中取得了成功。

● 激素受體陽性乳腺癌

對(duì)于激素受體陽性的乳腺癌,CDK4/6抑制劑如阿貝西利(Abemaciclib)、達(dá)爾西利(Dalpiciclib)和瑞波西利(Ribociclib)等藥物的開發(fā)為患者提供了新的治療選擇。這些藥物通過抑制細(xì)胞周期的關(guān)鍵調(diào)節(jié)因子,減緩腫瘤細(xì)胞的生長和擴(kuò)散。

● 三陰性乳腺癌

三陰性乳腺癌(TNBC)是一種較為難治的亞型,因?yàn)樗狈に厥荏w和HER2的表達(dá)。然而,免疫治療在這一領(lǐng)域取得了進(jìn)展,例如PD-1/PD-L1抑制劑在TNBC的治療中顯示出潛力。

免疫治療藥物

免疫治療是乳腺癌治療領(lǐng)域的另一個(gè)重要進(jìn)展。免疫檢查點(diǎn)抑制劑,如PD-1和PD-L1抑制劑,已經(jīng)在三陰性乳腺癌的治療中顯示出一定的療效。此外,研究者正在探索將免疫治療與其他治療方法結(jié)合使用的策略,以提高治療效果。

乳腺癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP023072HU1 Activity Verified

Measured in cell activity assay using U937 cells, the EC50 for this effect is 190.2-298.6 ng/ml.

CSB-MP007765HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active) CSB-MP4290MOV CD44 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active) CSB-MP004938HU(F1)j1-B CD44 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Human CD44 antigen (CD44), partial (Active) CSB-MP004938HU(F1) CD44 Mammalian cell C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal?10xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Interleukin-2 (IL2) (Active) CSB-MP011629HU IL2 Mammalian cell N-terminal hFc-tagged
Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) CSB-MP011649HU3 IL2RA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Hepatocyte growth factor receptor (MET), partial (Active) CSB-MP013714HU MET Mammalian cell C-terminal hFc-tagged
Recombinant Human Mesothelin (MSLN), partial (Active) CSB-MP015044HUc9 MSLN Mammalian cell N-terminal hFc-tagged
Recombinant Human Mucin-16 (MUC16), partial (Active) CSB-MP704410HU3c7 MUC16 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Nectin-4 (NECTIN4), partial (Active) CSB-MP822274HU NECTIN4 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human 5'-nucleotidase (NT5E) (Active) CSB-MP723415HU NT5E Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death protein 1 (PDCD1), partial (Active) CSB-MP619964HU1 PDCD1 Mammalian cell C-terminal 6xHis-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

ERBB2 Recombinant Monoclonal Antibody
CSB-RA260392A0HU
CSB-RA260392A0HU IHC

IHC image of CSB-RA260392A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system.

MET Recombinant Monoclonal Antibody
CSB-RA634199A0HU
CSB-RA634199A0HU IHC

IHC image of CSB-RA634199A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system.

CD44 Recombinant Monoclonal Antibody
CSB-RA292372A0HU
CSB-RA292372A0HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA292372A0HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
CA9 Recombinant Monoclonal Antibody CSB-RA614990A0HU CA9 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD27 Recombinant Monoclonal Antibody CSB-RA953976A0HU CD27 Human ELISA, WB
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938A0HU CD44 Human ELISA, WB, IHC
CD44 Recombinant Monoclonal Antibody CSB-RA292372A0HU CD44 Human ELISA, WB, IHC, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938MA1HU CD44 Human ELISA, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
EPCAM Recombinant Monoclonal Antibody CSB-RA932207A0HU EPCAM Human ELISA, WB

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測范圍 靈敏度
Human Carbonic Anhydrase 9(CA9) ELISA Kit CSB-E13266h CA9 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human cluster Of differentiation,CD44 ELISA Kit CSB-E11846h CD44 78 pg/mL-5000 pg/mL 19.5 pg/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit CSB-E10012h CSF1R 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit CSB-EL006044RA CSF1R 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit CSB-E04568h CSF2 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit CSB-E04569m CSF2 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Rat Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit CSB-E04570r CSF2 15.6 pg/ml - 1000 pg/ml 3.9 pg/ml
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL

參考文獻(xiàn):

1. Cell 186, April 13, 2023

2. Larissa A. Korde, Mark R. Somerfield, Dawn L. Hershman, et al. Use of Immune Checkpoint Inhibitor Pembrolizumab in the Treatment of High-Risk, Early-Stage Triple-Negative Breast Cancer: ASCO Guideline Rapid Recommendation Update. DOI: 10.1200/JCO.22.00503 Journal of Clinical Oncology

3. Lajos Pusztai, Carsten Denkert, Joyce O'Shaughnessy, et al. Event-free survival by residual cancer burden after neoadjuvant pembrolizumab + chemotherapy versus placebo + chemotherapy for early TNBC: Exploratory analysis from KEYNOTE-522. J Clin Oncol 40, 2022 (suppl 16; abstr 503). DOI: 10.1200/JCO.2022.40.16_suppl.503

4. Breast cancer-WHO: https://www.who.int/news-room/fact-sheets/detail/breast-cancer