內(nèi)分泌系統(tǒng)疾病
內(nèi)分泌系統(tǒng)疾病是一組影響內(nèi)分泌腺體正常功能的病狀,這些腺體包括但不限于甲狀腺、腎上腺、垂體和性腺等。這些疾病通常與激素分泌異常有關(guān),可能是激素水平過高或過低,導(dǎo)致身體多種生理功能失衡。
常見的內(nèi)分泌系統(tǒng)疾病包括糖尿病、甲狀腺功能異常(包括甲亢和甲減)、腎上腺疾?。ㄈ绨仙『蛶煨谰C合征)、垂體功能障礙、性腺疾病(如多囊卵巢綜合征)、骨質(zhì)疏松癥和肥胖癥等。
內(nèi)分泌系統(tǒng)疾病的藥物研針對不同疾病和病理機制,有多個靶點和治療策略。以下是一些主要疾病的藥物研發(fā)進展及其對應(yīng)的靶點:
- 糖尿?。?/b> 糖尿病藥物研發(fā)主要靶點包括胰島素分泌、胰島素抵抗、GLP-1受體、SGLT2等,現(xiàn)已開發(fā)了GLP-1受體激動劑(如利拉魯肽),SGLT2抑制劑(如達格列凈),以及新型胰島素類似物,這些藥物通過不同機制降低血糖水平。
- 甲狀腺疾?。?/b>甲狀腺疾病藥物研發(fā)主要靶點包括甲狀腺激素合成、甲狀腺激素受體、TSH受體等。目前甲亢的治療中,已采用β-阻滯劑(如普萘洛爾)和抗甲狀腺藥物(如甲巰咪唑)。甲減的治療則依賴于甲狀腺激素替代療法。
- 庫欣綜合征:庫欣綜合征藥物研發(fā)主要靶向皮質(zhì)醇合成和皮質(zhì)醇受體。治療可能包括使用皮質(zhì)醇合成抑制劑(如酮康唑)和皮質(zhì)醇受體拮抗劑(如米非司酮)。
- 生長激素異常:生長激素異常藥物研發(fā)主要靶向生長激素分泌和生長激素受體。生長激素缺乏癥的治療使用重組人生長激素,而肢端肥大癥可能使用生長激素受體拮抗劑(如培維索孟)。
- 肥胖癥:生長激素異常藥物研發(fā)主要針對食欲控制、能量消耗、脂肪吸收。新型藥物(如塞美拉肽)通過模擬GLP-1的作用減少饑餓感和食物攝入。
內(nèi)分泌系統(tǒng)疾病藥物靶點
- ABCD1
- ANGPT2
- AXL
- CD247
- CD274
- CD276
- CD28
- CD40
- CD40LG
- CD47
- CDH17
- CDH6
- CEACAM5
- CEACAM6
- CLDN18
- CLDN6
- CSF1R
- CSF2
- CSF3R
- CTAG1A
- CTLA4
- DNA2
- EGFR
- ENG
- EPCAM
- EPOR
- ERBB2
- ERBB3
- FGF21
- FGFR1
- FGFR3
- FLT1
- FOLR1
- FSHR
- GCGR
- GHR
- GIPR
- GLP1R
- GUCY2C
- HGF
- IAPP
- IFNAR1
- IGF1R
- IL10RA
- IL12A
- IL12RB1
- IL15
- IL15RA
- IL17A
- IL1A
- IL1B
- IL2
- IL2RA
- IL6
- IL6R
- IL6ST
- INSR
- LAG3
- LHCGR
- LILRB2
- MELTF
- MET
- MSLN
- MUC1
- MUC16
- NGFR
- NT5E
- ODC
- PCSK9
- PDCD1
- PDGFRB
- PGF
- PSCA
- PTH1R
- PTK7
- SLC34A2
- TACSTD2
- TF
- TGFB1
- TIGIT
- TNF
- TNFRSF10B
- TNFRSF4
- TNFSF11
- TNFSF9
- TOP1
- TOP2
- TP53
- TPBG
- TSHR
- TYRO3
- VEGFA
- VTCN1
- ZG16B
內(nèi)分泌系統(tǒng)疾病靶點相關(guān)產(chǎn)品推薦
● 靶點蛋白
CSB-MP009514HUb1
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP005498HU(A5)
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.
CSB-MP007479HU
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP009316HU1
Measured by its binding ability in a functional ELISA. Immobilized human GCGR at 2 μg/ml can bind Anti-GCGR recombinant antibody (CSB-RA009316A1HU), the EC50 is 3.747-6.666 ng/mL.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP007763HU
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
產(chǎn)品名稱 | 貨號 | 靶點 | 來源 | 蛋白標(biāo)簽 |
---|---|---|---|---|
Recombinant Human ATP-binding cassette sub-family D member 1 (ABCD1) (Active) | CSB-CF001068HU | ABCD1 | in vitro E.coli expression system | C-terminal 10xHis-tagged |
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) | CSB-MP001707HU(A4) | ANGPT2 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) | CSB-MP001707DO | ANGPT2 | Mammalian cell | C-terminal 6xHis-tagged |
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) | CSB-MP878942HU1 | CD274 | Mammalian cell | C-terminal hFc-tagged |
Recombinant Human CD276 antigen (CD276), partial (Active) | CSB-MP733578HU | CD276 | Mammalian cell | C-terminal hFc-Myc-tagged |
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | CSB-AP005181HU | CD40 | Mammalian cell | C-terminal Fc-tagged |
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | CSB-MP004936HU1 | CD40 | Mammalian cell | C-terminal hFc-tagged |
Recombinant Human CD40 ligand (CD40LG), partial (Active) | CSB-AP005191HU | CD40LG | E.coli | Tag-Free |
Recombinant Human CD40 ligand (CD40LG), partial (Active) | CSB-MP004937HU3 | CD40LG | Mammalian cell | N-terminal hFc-Flag-tagged |
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) | CSB-AP005201HU | CD47 | Mammalian cell | C-terminal 6xHis-tagged |
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) | CSB-AP005211HU | CD47 | Mammalian cell | C-terminal Fc-tagged |
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) | CSB-MP004940HU | CD47 | Mammalian cell | C-terminal hFc-tagged |
Recombinant Human Cadherin-17 (CDH17), partial (Active) | CSB-MP613267HU | CDH17 | Mammalian cell | C-terminal?10xHis-tagged |
Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) | CSB-MP4664MOV | CDH17 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) | CSB-MP005165HU | CEACAM5 | Mammalian cell | C-terminal?10xHis-tagged |
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active) | CSB-MP005166HU | CEACAM6 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active) | CSB-MP4304MOV | CLDN18 | Mammalian cell | N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions) |
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active) | CSB-MP005498MO(F3) | Cldn18 | Mammalian cell | N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions) |
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) | CSB-MP005508HU(A4) | CLDN6 | Mammalian cell | C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) |
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active) | CSB-MP005508HU(A4)f4 | CLDN6 | Mammalian cell | C-terminal GFP-tagged (This tag can be tested only under denaturing conditions) |
● 穩(wěn)定細胞株
HEK293T/Human CLDN6 Stable Cell Line
CSB-SC007681HU
Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
HEK293T/Human CDH17 Stable Cell Line
CSB-SC613267HU2
Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重組抗體
CSB-RA005498A2HU
Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2μg/1*106 cells).
CSB-RA159341A0HU
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
CSB-RA244537A0HU
Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
CSB-RA011087MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.
產(chǎn)品名稱 | 貨號 | 靶點 | 反應(yīng)種屬 | 應(yīng)用范圍 |
---|---|---|---|---|
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CDH17 Recombinant Monoclonal Antibody | CSB-RA613267MA1HU | CDH17 | Human | ELISA,F(xiàn)C |
CDH6 Recombinant Monoclonal Antibody | CSB-RA005055MA1HU | CDH6 | Human | ELISA |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
CLDN18 Recombinant Monoclonal Antibody | CSB-RA005498A2HU | CLDN18 | Human | ELISA, FC |
Claudin-18.2 Recombinant Monoclonal Antibody | CSB-RA005498A1HU | CLDN18 | Human | ELISA, FC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
● ELISA試劑盒
產(chǎn)品名稱 | 貨號 | 靶點 | 檢測范圍 | 靈敏度 |
---|---|---|---|---|
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit | CSB-EL002476HU | AXL | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit | CSB-EL002476MO | AXL | 31.25 pg/ml-2000 pg/ml | 7.81 pg/ml |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit | CSB-E14285h | CD276 | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
Human soluble cluster of differentiation 28,sCD28 ELISA Kit | CSB-E09296h | CD28 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E04716h | CD40LG | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E04717m | CD40LG | 0.274 ng/ml-200 ng/ml. | 0.274 ng/ml. |
Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E07395r | CD40LG | 1.87 ng/mL-120 ng/mL | 0.47 ng/mL |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human carcinoembryonic antigen,CEA ELISA Kit | CSB-E04767h | CEACAM5 | 5 ng/mL-120 ng/mL | 2 ng/mL |
Mouse carcinoembryonic antign,CEA ELISA Kit | CSB-E13925m | CEACAM5 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit | CSB-EL005166HU | CEACAM6 | 0.83 ng/mL-20 ng/mL | 0.33 ng/mL |