Your Good Partner in Biology Research

白血病

白血病是一種影響血液和骨髓的惡性腫瘤,它導(dǎo)致體內(nèi)產(chǎn)生大量未成熟或異常的白細(xì)胞,這些異常細(xì)胞可能會(huì)抑制正常血細(xì)胞的產(chǎn)生,從而引發(fā)各種癥狀和并發(fā)癥。白血病可以分為急性和慢性兩大類(lèi),根據(jù)細(xì)胞類(lèi)型又可分為髓系和淋巴系兩種。急性白血病的細(xì)胞分化停滯在早期階段,疾病發(fā)展迅速;而慢性白血病的細(xì)胞分化較好,發(fā)展緩慢。

白血病的藥物研發(fā)近年來(lái)取得了顯著進(jìn)展。例如,靶向治療藥物如酪氨酸激酶抑制劑(TKI)在慢性髓系白血?。–ML)的治療中取得了巨大成功,極大地改善了患者的預(yù)后。特別是三代TKI新藥的問(wèn)世,為CML患者提供了更多的治療選擇和更好的療效。

此外,CAR-T細(xì)胞療法作為一種新興的免疫治療方法,已經(jīng)在某些類(lèi)型的白血病治療中顯示出突破性的療效。CAR-T療法通過(guò)改造患者的T細(xì)胞,使其能夠識(shí)別并攻擊癌細(xì)胞。中國(guó)在CAR-T療法的研發(fā)上也取得了進(jìn)展,已有產(chǎn)品獲批上市,為患者提供了新的治療選擇。

全球范圍內(nèi),針對(duì)白血病治療的藥物研發(fā)非?;钴S,處于在研階段的藥物有上千個(gè)。其中靶向CD19的藥物數(shù)量最多,其次是Flt3抑制劑。中國(guó)在白血病治療藥物研發(fā)方面也取得了進(jìn)展,例如,基石藥業(yè)的艾伏尼布(Ivosidenib)在中國(guó)的注冊(cè)研究顯示了明確的療效和可控的安全性,有望成為中國(guó)首個(gè)獲批的IDH1抑制劑。

白血病藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP004925HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC50 of human CD33 protein is 4.289- 5.312 ng/ml.

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP023983HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L(CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml

CSB-MP004936HU1 Activity Verified

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來(lái)源 蛋白標(biāo)簽
Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active) CSB-MP004843HU CCR4 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active) CSB-MP004925HU CD33 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial (Active) CSB-MP004938HU(F1) CD44 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active) CSB-MP004938HU(F1)j1-B CD44 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active) CSB-MP4290MOV CD44 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active) CSB-MP004953HU CD7 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC004843HU2
CSB-SC004843HU2 FACS

HEK293T/Human CCR4 Stable Cell Line

Untransfected HEK293T cells (green line) and transfected Human CCR4 HEK293T stable cells (red line) were stained with anti-CCR4 antibody (CSB-MA236376) (2μg/1*106), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC020067HU
CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CCR4 Recombinant Monoclonal Antibody
CSB-RA004843MA01HU
CSB-RA004843MA01HU FC

Untransfected HEK293 cells surface (green line) and transfected Human CCR4 HEK293 stable cells surface (red line) were stained with anti-CCR4 antibody (2μl/1*106 cells)

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU
CSB-RA004931MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

CD44 Recombinant Monoclonal Antibody
CSB-RA004938MA1HU
CSB-RA004938MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA004938MA1HU (red line) at 1:100.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
CCR4 Recombinant Monoclonal Antibody CSB-RA004843MA01HU CCR4 Human ELISA, FC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938A0HU CD44 Human ELISA, WB, IHC
CD44 Recombinant Monoclonal Antibody CSB-RA292372A0HU CD44 Human ELISA, WB, IHC, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938MA1HU CD44 Human ELISA, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody CSB-RA004954MA1HU CD70 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
CXCR4 Recombinant Monoclonal Antibody CSB-RA569311A0HU CXCR4 Human ELISA, IF

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Myeloid cell surface antigen CD33(CD33) ELISA kit CSB-EL004925HU CD33 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit CSB-E09884h CD38 0.9 ng/mL-60 ng/mL 0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit CSB-EL004929MO CD38 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human cluster of differentiation 4,CD4 ELISA Kit CSB-E08956h CD4 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Rat cluster of differentiation 4,CD4 ELISA Kit CSB-E12928r CD4 0.78 U/mL-50 U/mL 0.195 U/mL
Chicken Cluster of Differentiation 4(CD4) ELISA Kit CSB-E13114C CD4 3.125 ng/mL-800 ng/mL 3.125 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human cluster Of differentiation,CD44 ELISA Kit CSB-E11846h CD44 78 pg/mL-5000 pg/mL 19.5 pg/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human CAMPATH-1 antigen(CD52) ELISA kit CSB-EL004943HU CD52 78 ng/mL-5000 ng/mL 19.5 ng/mL
Mouse cluster of differentiation 6(CD6) ELISA Kit CSB-EL004949MO CD6 Request Information Request Information
Human CD70 antigen(CD70) ELISA kit CSB-EL004954HU CD70 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Mouse CD70 antigen(CD70) ELISA kit CSB-EL004954MO CD70 Request Information Request Information
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit CSB-E12703r CXCR4 0.156 ng/mL-10 ng/mL 0.039 ng/mL