白血病
白血病是一種影響血液和骨髓的惡性腫瘤,它導(dǎo)致體內(nèi)產(chǎn)生大量未成熟或異常的白細(xì)胞,這些異常細(xì)胞可能會(huì)抑制正常血細(xì)胞的產(chǎn)生,從而引發(fā)各種癥狀和并發(fā)癥。白血病可以分為急性和慢性兩大類(lèi),根據(jù)細(xì)胞類(lèi)型又可分為髓系和淋巴系兩種。急性白血病的細(xì)胞分化停滯在早期階段,疾病發(fā)展迅速;而慢性白血病的細(xì)胞分化較好,發(fā)展緩慢。
白血病的藥物研發(fā)近年來(lái)取得了顯著進(jìn)展。例如,靶向治療藥物如酪氨酸激酶抑制劑(TKI)在慢性髓系白血?。–ML)的治療中取得了巨大成功,極大地改善了患者的預(yù)后。特別是三代TKI新藥的問(wèn)世,為CML患者提供了更多的治療選擇和更好的療效。
此外,CAR-T細(xì)胞療法作為一種新興的免疫治療方法,已經(jīng)在某些類(lèi)型的白血病治療中顯示出突破性的療效。CAR-T療法通過(guò)改造患者的T細(xì)胞,使其能夠識(shí)別并攻擊癌細(xì)胞。中國(guó)在CAR-T療法的研發(fā)上也取得了進(jìn)展,已有產(chǎn)品獲批上市,為患者提供了新的治療選擇。
全球范圍內(nèi),針對(duì)白血病治療的藥物研發(fā)非?;钴S,處于在研階段的藥物有上千個(gè)。其中靶向CD19的藥物數(shù)量最多,其次是Flt3抑制劑。中國(guó)在白血病治療藥物研發(fā)方面也取得了進(jìn)展,例如,基石藥業(yè)的艾伏尼布(Ivosidenib)在中國(guó)的注冊(cè)研究顯示了明確的療效和可控的安全性,有望成為中國(guó)首個(gè)獲批的IDH1抑制劑。
白血病藥物靶點(diǎn)
- ASRGL1
- CCR4
- CCR7
- CD19
- CD2
- CD22
- CD247
- CD274
- CD33
- CD37
- CD38
- CD3E
- CD4
- CD40
- CD44
- CD47
- CD52
- CD6
- CD7
- CD70
- CLEC12A
- CSF2RA
- CSF3R
- CTLA4
- CXCR4
- DNA2
- EpoR
- F10
- F7
- F9
- FCGR3A
- FLT3
- HAVCR2
- HLA-DRA
- IFNAR1
- IFNB1
- Ifngr1
- IL12RB1
- IL15
- IL15RA
- IL1B
- IL1RAP
- IL2
- IL2RA
- IL2RB
- IL3RA
- IL6
- IL6R
- IL6ST
- IL7R
- KIT
- KLRK1
- LAG3
- LGALS9
- LILRB4
- MS4A1
- PDCD1
- PTCRA
- ROR1
- SIRPA
- SPN
- TFRC
- TIGIT
- TNF
- TNFRSF13C
- TNFRSF17
- TNFRSF4
- TNFRSF8
- TNFSF9
- TOP1
- TOP2
- TRBC1
- VEGFA
白血病藥物靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP004900HU
Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP004925HU
Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC50 of human CD33 protein is 4.289- 5.312 ng/ml.
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP023983HU1
Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L(CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml
CSB-MP004936HU1
Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay
● 穩(wěn)定細(xì)胞株
HEK293T/Human CCR4 Stable Cell Line
Untransfected HEK293T cells (green line) and transfected Human CCR4 HEK293T stable cells (red line) were stained with anti-CCR4 antibody (CSB-MA236376) (2μg/1*106), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
CT26/Human ROR1 Stable Cell Line
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重組抗體
CSB-RA004843MA01HU
Untransfected HEK293 cells surface (green line) and transfected Human CCR4 HEK293 stable cells surface (red line) were stained with anti-CCR4 antibody (2μl/1*106 cells)
CSB-RA244537A0HU
Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
CSB-RA004931MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.
CSB-RA004938MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA004938MA1HU (red line) at 1:100.
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
---|---|---|---|---|
CCR4 Recombinant Monoclonal Antibody | CSB-RA004843MA01HU | CCR4 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD22 Recombinant Monoclonal Antibody | CSB-RA962691A0HU | CD22 | Human | ELISA, IHC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD44 Recombinant Monoclonal Antibody | CSB-RA004938A0HU | CD44 | Human | ELISA, WB, IHC |
CD44 Recombinant Monoclonal Antibody | CSB-RA292372A0HU | CD44 | Human | ELISA, WB, IHC, IF, FC |
CD44 Recombinant Monoclonal Antibody | CSB-RA004938MA1HU | CD44 | Human | ELISA, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CD70 Recombinant Monoclonal Antibody | CSB-RA004954MA1HU | CD70 | Human | ELISA |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
CXCR4 Recombinant Monoclonal Antibody | CSB-RA569311A0HU | CXCR4 | Human | ELISA, IF |
● ELISA試劑盒
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 檢測(cè)范圍 | 靈敏度 |
---|---|---|---|---|
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human Myeloid cell surface antigen CD33(CD33) ELISA kit | CSB-EL004925HU | CD33 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | CSB-E09884h | CD38 | 0.9 ng/mL-60 ng/mL | 0.225 ng/mL |
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | CSB-EL004929MO | CD38 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human cluster of differentiation 4,CD4 ELISA Kit | CSB-E08956h | CD4 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Rat cluster of differentiation 4,CD4 ELISA Kit | CSB-E12928r | CD4 | 0.78 U/mL-50 U/mL | 0.195 U/mL |
Chicken Cluster of Differentiation 4(CD4) ELISA Kit | CSB-E13114C | CD4 | 3.125 ng/mL-800 ng/mL | 3.125 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human cluster Of differentiation,CD44 ELISA Kit | CSB-E11846h | CD44 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human CAMPATH-1 antigen(CD52) ELISA kit | CSB-EL004943HU | CD52 | 78 ng/mL-5000 ng/mL | 19.5 ng/mL |
Mouse cluster of differentiation 6(CD6) ELISA Kit | CSB-EL004949MO | CD6 | Request Information | Request Information |
Human CD70 antigen(CD70) ELISA kit | CSB-EL004954HU | CD70 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Mouse CD70 antigen(CD70) ELISA kit | CSB-EL004954MO | CD70 | Request Information | Request Information |
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | CSB-E09171h | CTLA4 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | CSB-E13637m | CTLA4 | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit | CSB-E12703r | CXCR4 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |