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感染類疾病

感染類疾病是由細菌、病毒、真菌和寄生蟲等不同病原體引起的疾病,能夠影響人體各個系統(tǒng)和器官。這些疾病可以表現(xiàn)為輕微的皮膚感染,也可以是嚴重的全身性感染,如敗血癥。常見的感染類疾病包括細菌性肺炎、尿路感染、結(jié)核病;病毒性感染如流感、艾滋病、登革熱、COVID-19;真菌性感染如念珠菌病、癬??;以及寄生蟲感染如瘧疾、弓形蟲病。

治療感染類疾病通常需要使用相應的抗生素、抗病毒藥、抗真菌藥或抗寄生蟲藥,而疫苗接種是預防某些感染性疾病的有效手段。面對耐藥性微生物的挑戰(zhàn),新藥的研發(fā)和現(xiàn)有藥物的改進對于治療和控制感染類疾病至關(guān)重要。

在藥物研發(fā)方面,進展如下:

  • 抗菌藥物:研究集中在開發(fā)新型抗生素以對抗耐藥性問題,探索新的分子實體和作用機制,包括β內(nèi)酰胺類、大環(huán)內(nèi)酯類、喹諾酮類和碳青霉烯類抗生素的新型變體。
  • 抗病毒藥物:研發(fā)進展包括針對病毒復制酶、病毒蛋白酶、病毒進入宿主細胞的抑制,以及病毒釋放的阻斷,如流感的奧司他韋和HIV的逆轉(zhuǎn)錄酶及蛋白酶抑制劑。
  • 抗真菌藥物:研發(fā)重點在于解決耐藥性問題,開發(fā)新藥以干擾真菌細胞壁合成、影響真菌膜完整性和抑制真菌DNA復制,如棘白菌素類和嘧啶類似物。
  • 抗寄生蟲藥物:治療研究致力于干擾寄生蟲的代謝途徑、細胞結(jié)構(gòu),以及改變宿主-寄生蟲的相互作用。
  • 免疫調(diào)節(jié)劑和生物制劑:旨在增強宿主的免疫反應或減少自身免疫反應和炎癥,包括干擾素、腫瘤壞死因子(TNF)抑制劑和其他生物制劑。
  • 疫苗:疫苗研發(fā)是預防感染性疾病的關(guān)鍵,包括新型疫苗設計,如針對COVID-19的mRNA疫苗和病毒載體疫苗,以及現(xiàn)有疫苗的改進。

感染類疾病靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

MS4A1 (CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP023974HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP023983HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml

CSB-MP011649HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

產(chǎn)品名稱 貨號 靶點 來源 蛋白標簽
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active) CSB-AP005671HU ACE2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial, Biotinylated (Active) CSB-MP866317HU-B ACE2 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active) CSB-MP866317HU ACE2 Mammalian cell C-terminal hFc-tagged
Recombinant Macaca fascicularis Angiotensin-converting enzyme (ACE2), partial (Active) CSB-MP3414MOV ACE2 Mammalian cell C-terminal hFc-tagged
Recombinant Paguma larvata Angiotensin-converting enzyme 2 (ACE2), partial (Active) CSB-MP684964PAL ACE2 Mammalian cell C-terminal hFc-tagged
Recombinant Human Basigin (BSG), partial (Active) CSB-MP002831HU1 BSG Mammalian cell C-terminal hFc-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active) CSB-MP004925HU CD33 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active) CSB-MP004953HU CD7 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) CSB-AP005161HU CD86 Mammalian cell C-terminal 6xHis-tagged

● 穩(wěn)定細胞株

CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號 靶點 反應種屬 應用范圍
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody CSB-RA004954MA1HU CD70 Human ELISA
CD80 Recombinant Monoclonal Antibody CSB-RA246383A0HU CD80 Human ELISA, WB, IHC, IP
CD86 Recombinant Monoclonal Antibody CSB-RA004965A0HU CD86 Human ELISA, WB
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
CXCL10 Recombinant Monoclonal Antibody CSB-RA903061A0HU CXCL10 Human ELISA, IHC
CXCR4 Recombinant Monoclonal Antibody CSB-RA569311A0HU CXCR4 Human ELISA, IF

● ELISA試劑盒

產(chǎn)品名稱 貨號 靶點 檢測范圍 靈敏度
Rat Angiotensin converting enzyme 2, ACE2 ELISA Kit CSB-E14308r ACE2 0.02 ng/ml - 20 ng/ml 0.02 ng/ml
Human Angiotensin converting enzyme 2, ACE2 ELISA Kit CSB-E04489h ACE2 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Mouse Angiotensin converting enzyme 2(ACE2)ELISA Kit CSB-E17204m ACE2 6.25 pg/mL-400 pg/mL 1.56 pg/mL
Bovine Albumin(Alb) ELISA kit CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
Dog Albumin(Alb) ELISA Kit CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
Horse Albumin(Alb) ELISA Kit CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
Pig Albumin (Alb) ELISA Kit CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
Goat Albumin (Alb)ELISA Kit CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
Human Cluster of differentiation 147,CD147 Elisa Kit CSB-E12994h BSG 12.5 pg/mL-800 pg/mL 3.12 pg/mL
Human soluble cluster of differentiation 14,sCD14 ELISA Kit CSB-E13199h CD14 0.234 ng/mL-15 ng/mL 0.229 ng/mL
Rat soluble cluster of differentiation 14,sCD14 ELISA Kit CSB-E11178r CD14 28 ng/mL-1800 ng/mL 7 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Myeloid cell surface antigen CD33(CD33) ELISA kit CSB-EL004925HU CD33 125 pg/mL-8000 pg/mL 31.25 pg/mL